| Full name: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Alias Symbol: GPT|D11S366|DGPT|ALG7|CDG-Ij | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 1798 | HGNC ID: HGNC:2995 | Ensembl Gene: ENSG00000172269 | OMIM ID: 191350 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of DPAGT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DPAGT1 | 1798 | 209509_s_at | -0.1613 | 0.6666 | |
| GSE20347 | DPAGT1 | 1798 | 209509_s_at | -0.2480 | 0.0590 | |
| GSE23400 | DPAGT1 | 1798 | 209509_s_at | 0.0532 | 0.4788 | |
| GSE26886 | DPAGT1 | 1798 | 209509_s_at | -0.3554 | 0.1401 | |
| GSE29001 | DPAGT1 | 1798 | 209509_s_at | -0.3337 | 0.1590 | |
| GSE38129 | DPAGT1 | 1798 | 209509_s_at | -0.0827 | 0.4835 | |
| GSE45670 | DPAGT1 | 1798 | 209509_s_at | 0.2679 | 0.0280 | |
| GSE53622 | DPAGT1 | 1798 | 70821 | 0.1832 | 0.0277 | |
| GSE53624 | DPAGT1 | 1798 | 70821 | 0.1216 | 0.0722 | |
| GSE63941 | DPAGT1 | 1798 | 209509_s_at | -0.3357 | 0.4664 | |
| GSE77861 | DPAGT1 | 1798 | 209509_s_at | -0.1034 | 0.8209 | |
| GSE97050 | DPAGT1 | 1798 | A_23_P1775 | 0.5587 | 0.1163 | |
| SRP007169 | DPAGT1 | 1798 | RNAseq | -0.5121 | 0.1816 | |
| SRP008496 | DPAGT1 | 1798 | RNAseq | -0.4128 | 0.0589 | |
| SRP064894 | DPAGT1 | 1798 | RNAseq | 0.4750 | 0.0008 | |
| SRP133303 | DPAGT1 | 1798 | RNAseq | -0.0988 | 0.4442 | |
| SRP159526 | DPAGT1 | 1798 | RNAseq | 0.0306 | 0.9167 | |
| SRP193095 | DPAGT1 | 1798 | RNAseq | -0.2078 | 0.1156 | |
| SRP219564 | DPAGT1 | 1798 | RNAseq | 0.0100 | 0.9675 | |
| TCGA | DPAGT1 | 1798 | RNAseq | -0.0294 | 0.6200 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DPAGT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DPAGT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DPAGT1 | 1798 | 1 | 11 | 18 | |
| GSE20123 | DPAGT1 | 1798 | 1 | 11 | 18 | |
| GSE43470 | DPAGT1 | 1798 | 2 | 8 | 33 | |
| GSE46452 | DPAGT1 | 1798 | 3 | 26 | 30 | |
| GSE47630 | DPAGT1 | 1798 | 2 | 19 | 19 | |
| GSE54993 | DPAGT1 | 1798 | 10 | 0 | 60 | |
| GSE54994 | DPAGT1 | 1798 | 5 | 19 | 29 | |
| GSE60625 | DPAGT1 | 1798 | 0 | 3 | 8 | |
| GSE74703 | DPAGT1 | 1798 | 1 | 5 | 30 | |
| GSE74704 | DPAGT1 | 1798 | 0 | 7 | 13 | |
| TCGA | DPAGT1 | 1798 | 4 | 51 | 41 |
Total number of gains: 29; Total number of losses: 160; Total Number of normals: 299.
Somatic mutations of DPAGT1:
Generating mutation plots.
Highly correlated genes for DPAGT1:
Showing top 20/152 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DPAGT1 | SS18 | 0.754036 | 3 | 0 | 3 |
| DPAGT1 | RIPK3 | 0.729606 | 3 | 0 | 3 |
| DPAGT1 | CIDEB | 0.713587 | 3 | 0 | 3 |
| DPAGT1 | TUBB4B | 0.706652 | 3 | 0 | 3 |
| DPAGT1 | RPS6KB1 | 0.703164 | 3 | 0 | 3 |
| DPAGT1 | SYAP1 | 0.671855 | 3 | 0 | 3 |
| DPAGT1 | SERPINB9 | 0.671319 | 3 | 0 | 3 |
| DPAGT1 | OSBPL2 | 0.669593 | 3 | 0 | 3 |
| DPAGT1 | XPOT | 0.669276 | 3 | 0 | 3 |
| DPAGT1 | S100A11 | 0.6597 | 3 | 0 | 3 |
| DPAGT1 | CPPED1 | 0.658399 | 3 | 0 | 3 |
| DPAGT1 | TBC1D14 | 0.654702 | 3 | 0 | 3 |
| DPAGT1 | DNASE1L1 | 0.653853 | 4 | 0 | 3 |
| DPAGT1 | NDUFB11 | 0.650955 | 3 | 0 | 3 |
| DPAGT1 | TGDS | 0.650337 | 3 | 0 | 3 |
| DPAGT1 | AIMP1 | 0.648824 | 3 | 0 | 3 |
| DPAGT1 | NDN | 0.644822 | 3 | 0 | 3 |
| DPAGT1 | CAPN1 | 0.642214 | 4 | 0 | 4 |
| DPAGT1 | HDDC3 | 0.640474 | 3 | 0 | 3 |
| DPAGT1 | ORAI1 | 0.633013 | 3 | 0 | 3 |
For details and further investigation, click here
