| Full name: tubulin beta 4B class IVb | Alias Symbol: Beta2 | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 10383 | HGNC ID: HGNC:20771 | Ensembl Gene: ENSG00000188229 | OMIM ID: 602660 |
| Related drugs: BRENTUXIMAB VEDOTIN, CABAZITAXEL, COLCHICINE, CROLIBULIN, DAVUNETIDE, DOCETAXEL HYDRATE, ERIBULIN MESYLATE, FOSBRETABULIN DISODIUM, FOSBRETABULIN TROMETHAMINE, INDIBULIN... [more] | |||
Screen Evidence:
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TUBB4B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05130 | Pathogenic Escherichia coli infection |
Expression of TUBB4B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TUBB4B | 10383 | 208977_x_at | -0.3105 | 0.5570 | |
| GSE20347 | TUBB4B | 10383 | 213726_x_at | -0.1991 | 0.1863 | |
| GSE23400 | TUBB4B | 10383 | 213726_x_at | -0.0475 | 0.5512 | |
| GSE26886 | TUBB4B | 10383 | 213726_x_at | -0.1330 | 0.4452 | |
| GSE29001 | TUBB4B | 10383 | 213726_x_at | -0.2706 | 0.1340 | |
| GSE38129 | TUBB4B | 10383 | 208977_x_at | 0.0427 | 0.8065 | |
| GSE45670 | TUBB4B | 10383 | 208977_x_at | 0.0431 | 0.8017 | |
| GSE53622 | TUBB4B | 10383 | 36083 | 0.1882 | 0.0638 | |
| GSE53624 | TUBB4B | 10383 | 36083 | 0.2039 | 0.0011 | |
| GSE63941 | TUBB4B | 10383 | 213726_x_at | 0.8449 | 0.0378 | |
| GSE77861 | TUBB4B | 10383 | 213726_x_at | 0.3143 | 0.0262 | |
| GSE97050 | TUBB4B | 10383 | A_23_P312863 | 0.0548 | 0.8655 | |
| SRP007169 | TUBB4B | 10383 | RNAseq | -0.5507 | 0.1358 | |
| SRP008496 | TUBB4B | 10383 | RNAseq | -0.5321 | 0.0103 | |
| SRP064894 | TUBB4B | 10383 | RNAseq | 0.0291 | 0.9316 | |
| SRP133303 | TUBB4B | 10383 | RNAseq | 0.0460 | 0.8441 | |
| SRP159526 | TUBB4B | 10383 | RNAseq | 0.3160 | 0.3883 | |
| SRP193095 | TUBB4B | 10383 | RNAseq | -0.1549 | 0.3393 | |
| SRP219564 | TUBB4B | 10383 | RNAseq | -0.7303 | 0.1158 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TUBB4B expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of TUBB4B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TUBB4B | 10383 | 5 | 7 | 18 | |
| GSE20123 | TUBB4B | 10383 | 5 | 7 | 18 | |
| GSE43470 | TUBB4B | 10383 | 3 | 7 | 33 | |
| GSE46452 | TUBB4B | 10383 | 6 | 13 | 40 | |
| GSE47630 | TUBB4B | 10383 | 6 | 15 | 19 | |
| GSE54993 | TUBB4B | 10383 | 3 | 3 | 64 | |
| GSE54994 | TUBB4B | 10383 | 12 | 7 | 34 | |
| GSE60625 | TUBB4B | 10383 | 0 | 0 | 11 | |
| GSE74703 | TUBB4B | 10383 | 3 | 5 | 28 | |
| GSE74704 | TUBB4B | 10383 | 3 | 5 | 12 | |
| TCGA | TUBB4B | 10383 | 29 | 23 | 44 |
Total number of gains: 75; Total number of losses: 92; Total Number of normals: 321.
Somatic mutations of TUBB4B:
Generating mutation plots.
Highly correlated genes for TUBB4B:
Showing top 20/150 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TUBB4B | TUBB3 | 0.753756 | 10 | 0 | 9 |
| TUBB4B | NDUFAF3 | 0.752528 | 3 | 0 | 3 |
| TUBB4B | ZC3H18 | 0.727536 | 3 | 0 | 3 |
| TUBB4B | CLIP4 | 0.717396 | 4 | 0 | 4 |
| TUBB4B | KCTD1 | 0.715938 | 3 | 0 | 3 |
| TUBB4B | DPAGT1 | 0.706652 | 3 | 0 | 3 |
| TUBB4B | PPM1D | 0.705745 | 3 | 0 | 3 |
| TUBB4B | GPATCH8 | 0.694079 | 3 | 0 | 3 |
| TUBB4B | CRMP1 | 0.678663 | 3 | 0 | 3 |
| TUBB4B | ACTR3 | 0.678148 | 5 | 0 | 4 |
| TUBB4B | ELMOD3 | 0.677115 | 3 | 0 | 3 |
| TUBB4B | PHLDB1 | 0.667878 | 3 | 0 | 3 |
| TUBB4B | HAUS7 | 0.667731 | 3 | 0 | 3 |
| TUBB4B | DYNC1LI2 | 0.666041 | 3 | 0 | 3 |
| TUBB4B | GEMIN6 | 0.652948 | 3 | 0 | 3 |
| TUBB4B | CREB5 | 0.646269 | 3 | 0 | 3 |
| TUBB4B | CIAO1 | 0.645841 | 3 | 0 | 3 |
| TUBB4B | PRKX | 0.638784 | 3 | 0 | 3 |
| TUBB4B | ARPC5L | 0.631063 | 10 | 0 | 9 |
| TUBB4B | CENPT | 0.627379 | 4 | 0 | 3 |
For details and further investigation, click here
