| Full name: ribosomal protein S6 kinase B1 | Alias Symbol: S6K1|p70(S6K)-alpha|PS6K|S6K | ||
| Type: protein-coding gene | Cytoband: 17q23.1 | ||
| Entrez ID: 6198 | HGNC ID: HGNC:10436 | Ensembl Gene: ENSG00000108443 | OMIM ID: 608938 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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RPS6KB1 involved pathways:
Expression of RPS6KB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6KB1 | 6198 | 226660_at | -0.4641 | 0.2059 | |
| GSE20347 | RPS6KB1 | 6198 | 204171_at | -0.1386 | 0.3526 | |
| GSE23400 | RPS6KB1 | 6198 | 211578_s_at | -0.0673 | 0.1615 | |
| GSE26886 | RPS6KB1 | 6198 | 226660_at | -0.2103 | 0.4106 | |
| GSE29001 | RPS6KB1 | 6198 | 204171_at | 0.1255 | 0.7512 | |
| GSE38129 | RPS6KB1 | 6198 | 204171_at | -0.0264 | 0.8638 | |
| GSE45670 | RPS6KB1 | 6198 | 226660_at | -0.3305 | 0.0119 | |
| GSE53622 | RPS6KB1 | 6198 | 32214 | -0.3703 | 0.0000 | |
| GSE53624 | RPS6KB1 | 6198 | 92998 | -0.5019 | 0.0000 | |
| GSE63941 | RPS6KB1 | 6198 | 226660_at | -0.6608 | 0.3091 | |
| GSE77861 | RPS6KB1 | 6198 | 226660_at | 0.0478 | 0.8736 | |
| GSE97050 | RPS6KB1 | 6198 | A_33_P3362562 | 0.3652 | 0.3954 | |
| SRP007169 | RPS6KB1 | 6198 | RNAseq | -0.4002 | 0.2164 | |
| SRP008496 | RPS6KB1 | 6198 | RNAseq | -0.3128 | 0.0506 | |
| SRP064894 | RPS6KB1 | 6198 | RNAseq | -0.3558 | 0.0471 | |
| SRP133303 | RPS6KB1 | 6198 | RNAseq | 0.2588 | 0.0448 | |
| SRP159526 | RPS6KB1 | 6198 | RNAseq | -0.2702 | 0.2408 | |
| SRP193095 | RPS6KB1 | 6198 | RNAseq | -0.3126 | 0.0003 | |
| SRP219564 | RPS6KB1 | 6198 | RNAseq | -0.3913 | 0.3732 | |
| TCGA | RPS6KB1 | 6198 | RNAseq | -0.0228 | 0.6394 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RPS6KB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6KB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS6KB1 | 6198 | 6 | 1 | 23 | |
| GSE20123 | RPS6KB1 | 6198 | 6 | 1 | 23 | |
| GSE43470 | RPS6KB1 | 6198 | 5 | 0 | 38 | |
| GSE46452 | RPS6KB1 | 6198 | 32 | 0 | 27 | |
| GSE47630 | RPS6KB1 | 6198 | 7 | 1 | 32 | |
| GSE54993 | RPS6KB1 | 6198 | 2 | 5 | 63 | |
| GSE54994 | RPS6KB1 | 6198 | 9 | 5 | 39 | |
| GSE60625 | RPS6KB1 | 6198 | 4 | 0 | 7 | |
| GSE74703 | RPS6KB1 | 6198 | 5 | 0 | 31 | |
| GSE74704 | RPS6KB1 | 6198 | 5 | 1 | 14 | |
| TCGA | RPS6KB1 | 6198 | 30 | 6 | 60 |
Total number of gains: 111; Total number of losses: 20; Total Number of normals: 357.
Somatic mutations of RPS6KB1:
Generating mutation plots.
Highly correlated genes for RPS6KB1:
Showing top 20/524 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6KB1 | PPWD1 | 0.819469 | 3 | 0 | 3 |
| RPS6KB1 | RARS2 | 0.805431 | 3 | 0 | 3 |
| RPS6KB1 | EIF2S2 | 0.795103 | 3 | 0 | 3 |
| RPS6KB1 | MYSM1 | 0.784968 | 3 | 0 | 3 |
| RPS6KB1 | CDC40 | 0.765067 | 3 | 0 | 3 |
| RPS6KB1 | UBQLN1 | 0.738028 | 4 | 0 | 3 |
| RPS6KB1 | MITD1 | 0.714715 | 3 | 0 | 3 |
| RPS6KB1 | GIN1 | 0.71262 | 3 | 0 | 3 |
| RPS6KB1 | RAD23B | 0.712602 | 4 | 0 | 4 |
| RPS6KB1 | SWAP70 | 0.712348 | 3 | 0 | 3 |
| RPS6KB1 | LRIG3 | 0.711175 | 3 | 0 | 3 |
| RPS6KB1 | COPB2 | 0.709536 | 3 | 0 | 3 |
| RPS6KB1 | NCKAP1 | 0.709239 | 3 | 0 | 3 |
| RPS6KB1 | TPP2 | 0.70673 | 3 | 0 | 3 |
| RPS6KB1 | SKA2 | 0.70324 | 3 | 0 | 3 |
| RPS6KB1 | DPAGT1 | 0.703164 | 3 | 0 | 3 |
| RPS6KB1 | KIAA1143 | 0.702469 | 3 | 0 | 3 |
| RPS6KB1 | COMMD1 | 0.70205 | 4 | 0 | 3 |
| RPS6KB1 | REV1 | 0.70023 | 4 | 0 | 4 |
| RPS6KB1 | DPY19L3 | 0.695901 | 3 | 0 | 3 |
For details and further investigation, click here
