| Full name: exportin for tRNA | Alias Symbol: XPO3 | ||
| Type: protein-coding gene | Cytoband: 12q14.2 | ||
| Entrez ID: 11260 | HGNC ID: HGNC:12826 | Ensembl Gene: ENSG00000184575 | OMIM ID: 603180 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of XPOT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XPOT | 11260 | 212160_at | 0.4657 | 0.2941 | |
| GSE20347 | XPOT | 11260 | 212160_at | 0.8893 | 0.0000 | |
| GSE23400 | XPOT | 11260 | 212160_at | 0.9817 | 0.0000 | |
| GSE26886 | XPOT | 11260 | 212160_at | 0.0989 | 0.5045 | |
| GSE29001 | XPOT | 11260 | 212160_at | 0.6604 | 0.0002 | |
| GSE38129 | XPOT | 11260 | 212160_at | 1.0657 | 0.0000 | |
| GSE45670 | XPOT | 11260 | 212160_at | 0.5344 | 0.0004 | |
| GSE53622 | XPOT | 11260 | 51414 | 0.8540 | 0.0000 | |
| GSE53624 | XPOT | 11260 | 51414 | 0.7702 | 0.0000 | |
| GSE63941 | XPOT | 11260 | 212160_at | 0.2220 | 0.7431 | |
| GSE77861 | XPOT | 11260 | 212160_at | 0.5665 | 0.0248 | |
| GSE97050 | XPOT | 11260 | A_23_P340722 | 0.7194 | 0.1065 | |
| SRP007169 | XPOT | 11260 | RNAseq | 0.5955 | 0.2095 | |
| SRP008496 | XPOT | 11260 | RNAseq | 0.5072 | 0.0579 | |
| SRP064894 | XPOT | 11260 | RNAseq | 0.6315 | 0.0012 | |
| SRP133303 | XPOT | 11260 | RNAseq | 1.3473 | 0.0003 | |
| SRP159526 | XPOT | 11260 | RNAseq | 0.4754 | 0.0012 | |
| SRP193095 | XPOT | 11260 | RNAseq | 0.5680 | 0.0000 | |
| SRP219564 | XPOT | 11260 | RNAseq | 0.9066 | 0.1223 | |
| TCGA | XPOT | 11260 | RNAseq | 0.2670 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by XPOT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XPOT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XPOT | 11260 | 5 | 1 | 24 | |
| GSE20123 | XPOT | 11260 | 5 | 1 | 24 | |
| GSE43470 | XPOT | 11260 | 5 | 0 | 38 | |
| GSE46452 | XPOT | 11260 | 11 | 0 | 48 | |
| GSE47630 | XPOT | 11260 | 10 | 2 | 28 | |
| GSE54993 | XPOT | 11260 | 0 | 6 | 64 | |
| GSE54994 | XPOT | 11260 | 8 | 1 | 44 | |
| GSE60625 | XPOT | 11260 | 0 | 0 | 11 | |
| GSE74703 | XPOT | 11260 | 5 | 0 | 31 | |
| GSE74704 | XPOT | 11260 | 4 | 1 | 15 | |
| TCGA | XPOT | 11260 | 19 | 10 | 67 |
Total number of gains: 72; Total number of losses: 22; Total Number of normals: 394.
Somatic mutations of XPOT:
Generating mutation plots.
Highly correlated genes for XPOT:
Showing top 20/1826 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XPOT | KPNA2 | 0.813003 | 8 | 0 | 8 |
| XPOT | ECT2 | 0.80888 | 9 | 0 | 9 |
| XPOT | CEP55 | 0.800424 | 10 | 0 | 10 |
| XPOT | MTHFD2 | 0.794078 | 11 | 0 | 11 |
| XPOT | CCNB2 | 0.788938 | 9 | 0 | 9 |
| XPOT | RACGAP1 | 0.788465 | 8 | 0 | 8 |
| XPOT | PYCR2 | 0.788433 | 3 | 0 | 3 |
| XPOT | NUF2 | 0.786018 | 6 | 0 | 6 |
| XPOT | ATAD2 | 0.782032 | 10 | 0 | 10 |
| XPOT | CDCA2 | 0.777139 | 4 | 0 | 4 |
| XPOT | TIMELESS | 0.776451 | 10 | 0 | 10 |
| XPOT | BUB1 | 0.775146 | 8 | 0 | 8 |
| XPOT | MCM4 | 0.773728 | 10 | 0 | 10 |
| XPOT | TOP2A | 0.770262 | 10 | 0 | 10 |
| XPOT | ATP13A3 | 0.765899 | 10 | 0 | 10 |
| XPOT | KIF14 | 0.76416 | 10 | 0 | 10 |
| XPOT | FOXM1 | 0.763719 | 9 | 0 | 9 |
| XPOT | ACTL6A | 0.761904 | 11 | 0 | 10 |
| XPOT | ASPM | 0.761878 | 10 | 0 | 10 |
| XPOT | NEK2 | 0.761843 | 10 | 0 | 10 |
For details and further investigation, click here
