| Full name: receptor interacting serine/threonine kinase 3 | Alias Symbol: RIP3 | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 11035 | HGNC ID: HGNC:10021 | Ensembl Gene: ENSG00000129465 | OMIM ID: 605817 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RIPK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04623 | Cytosolic DNA-sensing pathway | |
| hsa04668 | TNF signaling pathway |
Expression of RIPK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RIPK3 | 11035 | 228139_at | -0.0610 | 0.9340 | |
| GSE26886 | RIPK3 | 11035 | 228139_at | -0.9802 | 0.0000 | |
| GSE45670 | RIPK3 | 11035 | 228139_at | -0.1718 | 0.4761 | |
| GSE53622 | RIPK3 | 11035 | 3644 | -0.9680 | 0.0000 | |
| GSE53624 | RIPK3 | 11035 | 3644 | -1.0354 | 0.0000 | |
| GSE63941 | RIPK3 | 11035 | 228139_at | 0.3490 | 0.2403 | |
| GSE77861 | RIPK3 | 11035 | 228139_at | -0.2992 | 0.0375 | |
| GSE97050 | RIPK3 | 11035 | A_23_P14559 | 0.4077 | 0.3592 | |
| SRP007169 | RIPK3 | 11035 | RNAseq | -1.9501 | 0.0047 | |
| SRP008496 | RIPK3 | 11035 | RNAseq | -2.0046 | 0.0000 | |
| SRP064894 | RIPK3 | 11035 | RNAseq | -0.2825 | 0.3385 | |
| SRP133303 | RIPK3 | 11035 | RNAseq | -0.7171 | 0.0010 | |
| SRP159526 | RIPK3 | 11035 | RNAseq | -1.6812 | 0.0122 | |
| SRP193095 | RIPK3 | 11035 | RNAseq | -0.9345 | 0.0000 | |
| SRP219564 | RIPK3 | 11035 | RNAseq | -0.5062 | 0.4262 | |
| TCGA | RIPK3 | 11035 | RNAseq | -0.5522 | 0.0046 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RIPK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RIPK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RIPK3 | 11035 | 8 | 3 | 19 | |
| GSE20123 | RIPK3 | 11035 | 8 | 3 | 19 | |
| GSE43470 | RIPK3 | 11035 | 8 | 2 | 33 | |
| GSE46452 | RIPK3 | 11035 | 16 | 2 | 41 | |
| GSE47630 | RIPK3 | 11035 | 11 | 10 | 19 | |
| GSE54993 | RIPK3 | 11035 | 3 | 11 | 56 | |
| GSE54994 | RIPK3 | 11035 | 18 | 5 | 30 | |
| GSE60625 | RIPK3 | 11035 | 0 | 2 | 9 | |
| GSE74703 | RIPK3 | 11035 | 7 | 2 | 27 | |
| GSE74704 | RIPK3 | 11035 | 3 | 2 | 15 | |
| TCGA | RIPK3 | 11035 | 27 | 12 | 57 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of RIPK3:
Generating mutation plots.
Highly correlated genes for RIPK3:
Showing top 20/979 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RIPK3 | ACTR3 | 0.821485 | 3 | 0 | 3 |
| RIPK3 | RNF6 | 0.788599 | 3 | 0 | 3 |
| RIPK3 | DIAPH1 | 0.757589 | 5 | 0 | 5 |
| RIPK3 | PTBP3 | 0.746613 | 3 | 0 | 3 |
| RIPK3 | TSC22D4 | 0.738441 | 3 | 0 | 3 |
| RIPK3 | OSTF1 | 0.735207 | 6 | 0 | 6 |
| RIPK3 | DPAGT1 | 0.729606 | 3 | 0 | 3 |
| RIPK3 | ELOVL1 | 0.724742 | 3 | 0 | 3 |
| RIPK3 | CRYBG3 | 0.718907 | 3 | 0 | 3 |
| RIPK3 | RABGGTA | 0.716747 | 6 | 0 | 6 |
| RIPK3 | CAPNS2 | 0.710441 | 4 | 0 | 4 |
| RIPK3 | GRN | 0.708459 | 5 | 0 | 5 |
| RIPK3 | AMMECR1 | 0.706759 | 3 | 0 | 3 |
| RIPK3 | PNP | 0.706689 | 3 | 0 | 3 |
| RIPK3 | RER1 | 0.706448 | 5 | 0 | 5 |
| RIPK3 | TBC1D2 | 0.705952 | 3 | 0 | 3 |
| RIPK3 | SPAG1 | 0.705104 | 4 | 0 | 3 |
| RIPK3 | TAX1BP3 | 0.700814 | 3 | 0 | 3 |
| RIPK3 | UNC13D | 0.699658 | 4 | 0 | 4 |
| RIPK3 | ORMDL2 | 0.691217 | 4 | 0 | 4 |
For details and further investigation, click here
