| Full name: CCR4-NOT transcription complex subunit 1 | Alias Symbol: CDC39|NOT1H|KIAA1007|AD-005 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 23019 | HGNC ID: HGNC:7877 | Ensembl Gene: ENSG00000125107 | OMIM ID: 604917 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CNOT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CNOT1 | 23019 | 200860_s_at | 0.0342 | 0.9641 | |
| GSE20347 | CNOT1 | 23019 | 200860_s_at | -0.2256 | 0.0196 | |
| GSE23400 | CNOT1 | 23019 | 200860_s_at | -0.3453 | 0.0000 | |
| GSE26886 | CNOT1 | 23019 | 200860_s_at | -1.2019 | 0.0000 | |
| GSE29001 | CNOT1 | 23019 | 200860_s_at | -0.6713 | 0.0226 | |
| GSE38129 | CNOT1 | 23019 | 200860_s_at | -0.1324 | 0.2944 | |
| GSE45670 | CNOT1 | 23019 | 200860_s_at | -0.1259 | 0.4281 | |
| GSE53622 | CNOT1 | 23019 | 38245 | -0.3807 | 0.0000 | |
| GSE53624 | CNOT1 | 23019 | 38245 | -0.4406 | 0.0000 | |
| GSE63941 | CNOT1 | 23019 | 200860_s_at | 1.4620 | 0.0002 | |
| GSE77861 | CNOT1 | 23019 | 200860_s_at | -0.2922 | 0.1800 | |
| GSE97050 | CNOT1 | 23019 | A_24_P101114 | -0.1789 | 0.5099 | |
| SRP007169 | CNOT1 | 23019 | RNAseq | -0.9094 | 0.0064 | |
| SRP008496 | CNOT1 | 23019 | RNAseq | -1.0322 | 0.0000 | |
| SRP064894 | CNOT1 | 23019 | RNAseq | -1.1002 | 0.0000 | |
| SRP133303 | CNOT1 | 23019 | RNAseq | -0.2628 | 0.0715 | |
| SRP159526 | CNOT1 | 23019 | RNAseq | -0.6867 | 0.0023 | |
| SRP193095 | CNOT1 | 23019 | RNAseq | -0.5718 | 0.0000 | |
| SRP219564 | CNOT1 | 23019 | RNAseq | -1.1125 | 0.0139 | |
| TCGA | CNOT1 | 23019 | RNAseq | -0.0144 | 0.7476 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by CNOT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CNOT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CNOT1 | 23019 | 7 | 0 | 23 | |
| GSE20123 | CNOT1 | 23019 | 7 | 0 | 23 | |
| GSE43470 | CNOT1 | 23019 | 2 | 7 | 34 | |
| GSE46452 | CNOT1 | 23019 | 38 | 1 | 20 | |
| GSE47630 | CNOT1 | 23019 | 10 | 8 | 22 | |
| GSE54993 | CNOT1 | 23019 | 2 | 4 | 64 | |
| GSE54994 | CNOT1 | 23019 | 7 | 9 | 37 | |
| GSE60625 | CNOT1 | 23019 | 4 | 0 | 7 | |
| GSE74703 | CNOT1 | 23019 | 2 | 5 | 29 | |
| GSE74704 | CNOT1 | 23019 | 5 | 0 | 15 | |
| TCGA | CNOT1 | 23019 | 26 | 11 | 59 |
Total number of gains: 110; Total number of losses: 45; Total Number of normals: 333.
Somatic mutations of CNOT1:
Generating mutation plots.
Highly correlated genes for CNOT1:
Showing top 20/1195 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CNOT1 | ARPC1A | 0.823992 | 4 | 0 | 4 |
| CNOT1 | MRPL38 | 0.797817 | 3 | 0 | 3 |
| CNOT1 | FBXO16 | 0.794797 | 3 | 0 | 3 |
| CNOT1 | FYTTD1 | 0.780714 | 3 | 0 | 3 |
| CNOT1 | TP53RK | 0.776758 | 3 | 0 | 3 |
| CNOT1 | ASH2L | 0.762801 | 3 | 0 | 3 |
| CNOT1 | FAM122A | 0.761709 | 3 | 0 | 3 |
| CNOT1 | PRPF38A | 0.760969 | 5 | 0 | 5 |
| CNOT1 | THAP11 | 0.758226 | 3 | 0 | 3 |
| CNOT1 | MRRF | 0.750268 | 3 | 0 | 3 |
| CNOT1 | DR1 | 0.741644 | 3 | 0 | 3 |
| CNOT1 | MRPL30 | 0.735597 | 4 | 0 | 3 |
| CNOT1 | TMED4 | 0.734235 | 3 | 0 | 3 |
| CNOT1 | RBM20 | 0.733176 | 4 | 0 | 4 |
| CNOT1 | SLC35A4 | 0.73285 | 4 | 0 | 4 |
| CNOT1 | PFKP | 0.73088 | 3 | 0 | 3 |
| CNOT1 | MRPL37 | 0.727702 | 5 | 0 | 5 |
| CNOT1 | DDI2 | 0.726258 | 3 | 0 | 3 |
| CNOT1 | ATP6V1G1 | 0.724897 | 3 | 0 | 3 |
| CNOT1 | EEFSEC | 0.720523 | 3 | 0 | 3 |
For details and further investigation, click here
