| Full name: eukaryotic translation initiation factor 2B subunit epsilon | Alias Symbol: EIF2Bepsilon|EIF-2B | ||
| Type: protein-coding gene | Cytoband: 3q27.1 | ||
| Entrez ID: 8893 | HGNC ID: HGNC:3261 | Ensembl Gene: ENSG00000145191 | OMIM ID: 603945 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF2B5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2B5 | 8893 | 212351_at | 0.3446 | 0.2326 | |
| GSE20347 | EIF2B5 | 8893 | 212351_at | 0.5666 | 0.0000 | |
| GSE23400 | EIF2B5 | 8893 | 212351_at | 0.3668 | 0.0000 | |
| GSE26886 | EIF2B5 | 8893 | 212351_at | 0.1763 | 0.4033 | |
| GSE29001 | EIF2B5 | 8893 | 212351_at | 0.4900 | 0.0155 | |
| GSE38129 | EIF2B5 | 8893 | 212351_at | 0.5764 | 0.0000 | |
| GSE45670 | EIF2B5 | 8893 | 212351_at | 0.4970 | 0.0126 | |
| GSE53622 | EIF2B5 | 8893 | 13620 | 0.4459 | 0.0000 | |
| GSE53624 | EIF2B5 | 8893 | 13620 | 0.4009 | 0.0000 | |
| GSE63941 | EIF2B5 | 8893 | 212351_at | 0.5534 | 0.1903 | |
| GSE77861 | EIF2B5 | 8893 | 212351_at | 0.5461 | 0.0581 | |
| GSE97050 | EIF2B5 | 8893 | A_23_P110062 | 0.4475 | 0.1471 | |
| SRP007169 | EIF2B5 | 8893 | RNAseq | 0.6782 | 0.1476 | |
| SRP008496 | EIF2B5 | 8893 | RNAseq | 0.5348 | 0.0555 | |
| SRP064894 | EIF2B5 | 8893 | RNAseq | 0.6269 | 0.0000 | |
| SRP133303 | EIF2B5 | 8893 | RNAseq | 0.5278 | 0.0010 | |
| SRP159526 | EIF2B5 | 8893 | RNAseq | 0.7447 | 0.0003 | |
| SRP193095 | EIF2B5 | 8893 | RNAseq | 0.4556 | 0.0000 | |
| SRP219564 | EIF2B5 | 8893 | RNAseq | 0.1227 | 0.6431 | |
| TCGA | EIF2B5 | 8893 | RNAseq | 0.1074 | 0.0300 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EIF2B5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2B5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2B5 | 8893 | 25 | 0 | 5 | |
| GSE20123 | EIF2B5 | 8893 | 25 | 0 | 5 | |
| GSE43470 | EIF2B5 | 8893 | 25 | 0 | 18 | |
| GSE46452 | EIF2B5 | 8893 | 19 | 1 | 39 | |
| GSE47630 | EIF2B5 | 8893 | 27 | 2 | 11 | |
| GSE54993 | EIF2B5 | 8893 | 1 | 19 | 50 | |
| GSE54994 | EIF2B5 | 8893 | 41 | 0 | 12 | |
| GSE60625 | EIF2B5 | 8893 | 0 | 6 | 5 | |
| GSE74703 | EIF2B5 | 8893 | 21 | 0 | 15 | |
| GSE74704 | EIF2B5 | 8893 | 17 | 0 | 3 | |
| TCGA | EIF2B5 | 8893 | 77 | 0 | 19 |
Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.
Somatic mutations of EIF2B5:
Generating mutation plots.
Highly correlated genes for EIF2B5:
Showing top 20/1355 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2B5 | CCDC15 | 0.784164 | 3 | 0 | 3 |
| EIF2B5 | NSD1 | 0.757671 | 3 | 0 | 3 |
| EIF2B5 | NECAP1 | 0.753477 | 3 | 0 | 3 |
| EIF2B5 | LRRC58 | 0.74894 | 5 | 0 | 4 |
| EIF2B5 | ACTL6A | 0.744416 | 11 | 0 | 11 |
| EIF2B5 | DRAP1 | 0.741423 | 3 | 0 | 3 |
| EIF2B5 | ABCF3 | 0.739394 | 12 | 0 | 11 |
| EIF2B5 | DPP9 | 0.73685 | 3 | 0 | 3 |
| EIF2B5 | PSMD2 | 0.735871 | 11 | 0 | 11 |
| EIF2B5 | PARL | 0.732144 | 12 | 0 | 11 |
| EIF2B5 | MAGEF1 | 0.719982 | 11 | 0 | 11 |
| EIF2B5 | HMBOX1 | 0.719919 | 3 | 0 | 3 |
| EIF2B5 | PRDM15 | 0.717397 | 4 | 0 | 3 |
| EIF2B5 | MRPL47 | 0.715211 | 8 | 0 | 7 |
| EIF2B5 | PDCD2L | 0.714301 | 4 | 0 | 4 |
| EIF2B5 | RBM4B | 0.712752 | 3 | 0 | 3 |
| EIF2B5 | NCBP2 | 0.710166 | 10 | 0 | 10 |
| EIF2B5 | ZNF75A | 0.709657 | 3 | 0 | 3 |
| EIF2B5 | EIF1AX | 0.709611 | 3 | 0 | 3 |
| EIF2B5 | LEMD2 | 0.707399 | 4 | 0 | 3 |
For details and further investigation, click here
