| Full name: SH3 and multiple ankyrin repeat domains 3 | Alias Symbol: SPANK-2|prosap2|KIAA1650|PSAP2 | ||
| Type: protein-coding gene | Cytoband: 22q13.33 | ||
| Entrez ID: 85358 | HGNC ID: HGNC:14294 | Ensembl Gene: ENSG00000251322 | OMIM ID: 606230 |
| Drug and gene relationship at DGIdb | |||
Expression of SHANK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SHANK3 | 85358 | 227923_at | -0.2358 | 0.7305 | |
| GSE26886 | SHANK3 | 85358 | 227923_at | 0.7991 | 0.0102 | |
| GSE45670 | SHANK3 | 85358 | 227923_at | -0.4793 | 0.0614 | |
| GSE53622 | SHANK3 | 85358 | 14439 | -0.1919 | 0.0197 | |
| GSE53624 | SHANK3 | 85358 | 14439 | -0.0101 | 0.9127 | |
| GSE63941 | SHANK3 | 85358 | 229698_at | 0.0422 | 0.8060 | |
| GSE77861 | SHANK3 | 85358 | 227923_at | 0.7011 | 0.0293 | |
| GSE97050 | SHANK3 | 85358 | A_24_P194881 | 0.1082 | 0.7426 | |
| SRP007169 | SHANK3 | 85358 | RNAseq | 0.5617 | 0.2242 | |
| SRP008496 | SHANK3 | 85358 | RNAseq | 0.5338 | 0.1777 | |
| SRP064894 | SHANK3 | 85358 | RNAseq | 0.3329 | 0.2421 | |
| SRP133303 | SHANK3 | 85358 | RNAseq | -0.6831 | 0.0001 | |
| SRP159526 | SHANK3 | 85358 | RNAseq | -0.0175 | 0.9539 | |
| SRP193095 | SHANK3 | 85358 | RNAseq | 0.7530 | 0.0006 | |
| SRP219564 | SHANK3 | 85358 | RNAseq | -0.2850 | 0.3242 | |
| TCGA | SHANK3 | 85358 | RNAseq | -0.1193 | 0.0515 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SHANK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SHANK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SHANK3 | 85358 | 3 | 8 | 19 | |
| GSE20123 | SHANK3 | 85358 | 3 | 8 | 19 | |
| GSE43470 | SHANK3 | 85358 | 2 | 8 | 33 | |
| GSE46452 | SHANK3 | 85358 | 31 | 2 | 26 | |
| GSE47630 | SHANK3 | 85358 | 9 | 4 | 27 | |
| GSE54993 | SHANK3 | 85358 | 4 | 6 | 60 | |
| GSE54994 | SHANK3 | 85358 | 11 | 8 | 34 | |
| GSE60625 | SHANK3 | 85358 | 5 | 0 | 6 | |
| GSE74703 | SHANK3 | 85358 | 2 | 6 | 28 | |
| GSE74704 | SHANK3 | 85358 | 1 | 4 | 15 | |
| TCGA | SHANK3 | 85358 | 26 | 16 | 54 |
Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.
Somatic mutations of SHANK3:
Generating mutation plots.
Highly correlated genes for SHANK3:
Showing top 20/346 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SHANK3 | GAS2L1 | 0.830491 | 3 | 0 | 3 |
| SHANK3 | CD93 | 0.795503 | 3 | 0 | 3 |
| SHANK3 | TEAD4 | 0.778056 | 3 | 0 | 3 |
| SHANK3 | SF3B4 | 0.764342 | 3 | 0 | 3 |
| SHANK3 | MSTO1 | 0.762533 | 3 | 0 | 3 |
| SHANK3 | MPG | 0.76239 | 3 | 0 | 3 |
| SHANK3 | CCDC86 | 0.758809 | 3 | 0 | 3 |
| SHANK3 | KRTCAP2 | 0.758766 | 3 | 0 | 3 |
| SHANK3 | TTC7B | 0.756235 | 3 | 0 | 3 |
| SHANK3 | PFDN2 | 0.752043 | 3 | 0 | 3 |
| SHANK3 | CD44 | 0.748066 | 3 | 0 | 3 |
| SHANK3 | DOLK | 0.740844 | 3 | 0 | 3 |
| SHANK3 | TRMT2A | 0.739208 | 3 | 0 | 3 |
| SHANK3 | CABYR | 0.736768 | 3 | 0 | 3 |
| SHANK3 | VEGFB | 0.735754 | 3 | 0 | 3 |
| SHANK3 | ARPC1B | 0.734356 | 3 | 0 | 3 |
| SHANK3 | DPP4 | 0.732616 | 3 | 0 | 3 |
| SHANK3 | DRAP1 | 0.731508 | 3 | 0 | 3 |
| SHANK3 | ADAR | 0.731336 | 3 | 0 | 3 |
| SHANK3 | SNAPC2 | 0.730476 | 3 | 0 | 3 |
For details and further investigation, click here
