| Full name: dopamine receptor D4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p15.5 | ||
| Entrez ID: 1815 | HGNC ID: HGNC:3025 | Ensembl Gene: ENSG00000069696 | OMIM ID: 126452 |
| Drug and gene relationship at DGIdb | |||
DRD4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04728 | Dopaminergic synapse |
Expression of DRD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DRD4 | 1815 | 208215_x_at | -0.0457 | 0.9011 | |
| GSE20347 | DRD4 | 1815 | 208215_x_at | -0.0791 | 0.2082 | |
| GSE23400 | DRD4 | 1815 | 208215_x_at | -0.0225 | 0.5288 | |
| GSE26886 | DRD4 | 1815 | 208215_x_at | 0.4120 | 0.0124 | |
| GSE29001 | DRD4 | 1815 | 208215_x_at | -0.0369 | 0.8318 | |
| GSE38129 | DRD4 | 1815 | 208215_x_at | 0.0168 | 0.7546 | |
| GSE45670 | DRD4 | 1815 | 208215_x_at | -0.0659 | 0.5577 | |
| GSE53622 | DRD4 | 1815 | 96713 | -0.1309 | 0.0211 | |
| GSE53624 | DRD4 | 1815 | 96713 | -0.0542 | 0.4749 | |
| GSE63941 | DRD4 | 1815 | 208215_x_at | 0.0944 | 0.5889 | |
| GSE77861 | DRD4 | 1815 | 208215_x_at | -0.0978 | 0.3535 | |
| GSE97050 | DRD4 | 1815 | A_33_P3373765 | -0.6659 | 0.2084 | |
| SRP133303 | DRD4 | 1815 | RNAseq | -0.2430 | 0.4453 | |
| SRP159526 | DRD4 | 1815 | RNAseq | 0.3320 | 0.6161 | |
| SRP219564 | DRD4 | 1815 | RNAseq | 0.3393 | 0.4243 | |
| TCGA | DRD4 | 1815 | RNAseq | 0.3021 | 0.1797 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DRD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DRD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DRD4 | 1815 | 1 | 11 | 18 | |
| GSE20123 | DRD4 | 1815 | 1 | 12 | 17 | |
| GSE43470 | DRD4 | 1815 | 1 | 10 | 32 | |
| GSE46452 | DRD4 | 1815 | 7 | 8 | 44 | |
| GSE47630 | DRD4 | 1815 | 4 | 12 | 24 | |
| GSE54993 | DRD4 | 1815 | 3 | 1 | 66 | |
| GSE54994 | DRD4 | 1815 | 1 | 12 | 40 | |
| GSE60625 | DRD4 | 1815 | 0 | 0 | 11 | |
| GSE74703 | DRD4 | 1815 | 1 | 8 | 27 | |
| GSE74704 | DRD4 | 1815 | 0 | 8 | 12 | |
| TCGA | DRD4 | 1815 | 8 | 38 | 50 |
Total number of gains: 27; Total number of losses: 120; Total Number of normals: 341.
Somatic mutations of DRD4:
Generating mutation plots.
Highly correlated genes for DRD4:
Showing top 20/439 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DRD4 | GALR2 | 0.746774 | 3 | 0 | 3 |
| DRD4 | LRRC46 | 0.725563 | 3 | 0 | 3 |
| DRD4 | BHLHA9 | 0.70764 | 3 | 0 | 3 |
| DRD4 | ARFIP2 | 0.704448 | 3 | 0 | 3 |
| DRD4 | TMEM37 | 0.700496 | 3 | 0 | 3 |
| DRD4 | C1orf61 | 0.697614 | 3 | 0 | 3 |
| DRD4 | TTLL9 | 0.693546 | 3 | 0 | 3 |
| DRD4 | TNNC2 | 0.688826 | 4 | 0 | 3 |
| DRD4 | WDR60 | 0.687413 | 3 | 0 | 3 |
| DRD4 | IQCH | 0.682884 | 4 | 0 | 4 |
| DRD4 | LMAN1L | 0.68102 | 4 | 0 | 3 |
| DRD4 | MIR146A | 0.670829 | 3 | 0 | 3 |
| DRD4 | BSND | 0.670424 | 4 | 0 | 4 |
| DRD4 | EGR4 | 0.669301 | 4 | 0 | 4 |
| DRD4 | C1QTNF1-AS1 | 0.663074 | 3 | 0 | 3 |
| DRD4 | GJB1 | 0.662067 | 5 | 0 | 5 |
| DRD4 | LINC00598 | 0.660177 | 4 | 0 | 4 |
| DRD4 | ISLR2 | 0.659106 | 4 | 0 | 4 |
| DRD4 | ARHGAP30 | 0.658046 | 4 | 0 | 3 |
| DRD4 | PPP1R12C | 0.654297 | 3 | 0 | 3 |
For details and further investigation, click here
