| Full name: drosha ribonuclease III | Alias Symbol: RNASE3L|Etohi2|HSA242976|RN3 | ||
| Type: protein-coding gene | Cytoband: 5p13.3 | ||
| Entrez ID: 29102 | HGNC ID: HGNC:17904 | Ensembl Gene: ENSG00000113360 | OMIM ID: 608828 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DROSHA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of DROSHA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DROSHA | 29102 | 218269_at | 0.6744 | 0.1116 | |
| GSE20347 | DROSHA | 29102 | 218269_at | 0.5826 | 0.0000 | |
| GSE23400 | DROSHA | 29102 | 218269_at | 0.4690 | 0.0000 | |
| GSE26886 | DROSHA | 29102 | 218269_at | 1.1753 | 0.0000 | |
| GSE29001 | DROSHA | 29102 | 218269_at | 0.7354 | 0.0071 | |
| GSE38129 | DROSHA | 29102 | 218269_at | 0.4790 | 0.0000 | |
| GSE45670 | DROSHA | 29102 | 218269_at | 0.5391 | 0.0063 | |
| GSE53622 | DROSHA | 29102 | 31645 | 0.3526 | 0.0000 | |
| GSE53624 | DROSHA | 29102 | 31645 | 0.6108 | 0.0000 | |
| GSE63941 | DROSHA | 29102 | 218269_at | -0.0138 | 0.9732 | |
| GSE77861 | DROSHA | 29102 | 218269_at | 0.5423 | 0.0993 | |
| GSE97050 | DROSHA | 29102 | A_23_P133596 | 0.1608 | 0.4368 | |
| SRP007169 | DROSHA | 29102 | RNAseq | 0.9245 | 0.0039 | |
| SRP008496 | DROSHA | 29102 | RNAseq | 0.8823 | 0.0003 | |
| SRP064894 | DROSHA | 29102 | RNAseq | 0.7151 | 0.0004 | |
| SRP133303 | DROSHA | 29102 | RNAseq | 0.3394 | 0.0205 | |
| SRP159526 | DROSHA | 29102 | RNAseq | 0.8721 | 0.0128 | |
| SRP193095 | DROSHA | 29102 | RNAseq | 0.3921 | 0.0001 | |
| SRP219564 | DROSHA | 29102 | RNAseq | 0.2511 | 0.2624 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DROSHA expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of DROSHA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DROSHA | 29102 | 12 | 0 | 18 | |
| GSE20123 | DROSHA | 29102 | 12 | 0 | 18 | |
| GSE43470 | DROSHA | 29102 | 16 | 3 | 24 | |
| GSE46452 | DROSHA | 29102 | 6 | 21 | 32 | |
| GSE47630 | DROSHA | 29102 | 6 | 12 | 22 | |
| GSE54993 | DROSHA | 29102 | 5 | 4 | 61 | |
| GSE54994 | DROSHA | 29102 | 27 | 2 | 24 | |
| GSE60625 | DROSHA | 29102 | 0 | 0 | 11 | |
| GSE74703 | DROSHA | 29102 | 13 | 2 | 21 | |
| GSE74704 | DROSHA | 29102 | 11 | 0 | 9 | |
| TCGA | DROSHA | 29102 | 51 | 6 | 39 |
Total number of gains: 159; Total number of losses: 50; Total Number of normals: 279.
Somatic mutations of DROSHA:
Generating mutation plots.
Highly correlated genes for DROSHA:
Showing top 20/1556 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DROSHA | PRR12 | 0.792602 | 3 | 0 | 3 |
| DROSHA | WDR81 | 0.791207 | 4 | 0 | 4 |
| DROSHA | RBPJ | 0.784961 | 3 | 0 | 3 |
| DROSHA | ARHGAP18 | 0.783035 | 3 | 0 | 3 |
| DROSHA | KCNMB4 | 0.764001 | 3 | 0 | 3 |
| DROSHA | RICTOR | 0.763423 | 6 | 0 | 5 |
| DROSHA | GMEB2 | 0.761254 | 4 | 0 | 3 |
| DROSHA | GPC4 | 0.760701 | 3 | 0 | 3 |
| DROSHA | KIAA1586 | 0.753183 | 3 | 0 | 3 |
| DROSHA | UBB | 0.749018 | 3 | 0 | 3 |
| DROSHA | RAVER1 | 0.746116 | 4 | 0 | 4 |
| DROSHA | WDR25 | 0.746066 | 3 | 0 | 3 |
| DROSHA | ZNF805 | 0.74386 | 3 | 0 | 3 |
| DROSHA | FAM13A | 0.741056 | 3 | 0 | 3 |
| DROSHA | BRIX1 | 0.740122 | 11 | 0 | 10 |
| DROSHA | ZDHHC14 | 0.739913 | 3 | 0 | 3 |
| DROSHA | WDR4 | 0.733603 | 3 | 0 | 3 |
| DROSHA | PDE7A | 0.732859 | 6 | 0 | 6 |
| DROSHA | NFXL1 | 0.732305 | 3 | 0 | 3 |
| DROSHA | ZFYVE27 | 0.730922 | 5 | 0 | 4 |
For details and further investigation, click here
