| Full name: heat shock protein family A (Hsp70) member 6 | Alias Symbol: HSP70B' | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 3310 | HGNC ID: HGNC:5239 | Ensembl Gene: ENSG00000173110 | OMIM ID: 140555 |
| Drug and gene relationship at DGIdb | |||
HSPA6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04213 | Longevity regulating pathway - multiple species | |
| hsa05134 | Legionellosis | |
| hsa05145 | Toxoplasmosis | |
| hsa05164 | Influenza A |
Expression of HSPA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HSPA6 | 3310 | 213418_at | -0.1297 | 0.9610 | |
| GSE20347 | HSPA6 | 3310 | 213418_at | 0.5136 | 0.0749 | |
| GSE23400 | HSPA6 | 3310 | 213418_at | 0.1921 | 0.1351 | |
| GSE26886 | HSPA6 | 3310 | 213418_at | 0.1715 | 0.7024 | |
| GSE29001 | HSPA6 | 3310 | 213418_at | 0.4431 | 0.4001 | |
| GSE38129 | HSPA6 | 3310 | 213418_at | 0.6029 | 0.0627 | |
| GSE45670 | HSPA6 | 3310 | 213418_at | 0.2865 | 0.6636 | |
| GSE53622 | HSPA6 | 3310 | 161258 | 0.3855 | 0.0744 | |
| GSE53624 | HSPA6 | 3310 | 161258 | 0.3673 | 0.0026 | |
| GSE63941 | HSPA6 | 3310 | 213418_at | -0.1767 | 0.5065 | |
| GSE77861 | HSPA6 | 3310 | 117_at | 0.1070 | 0.6011 | |
| GSE97050 | HSPA6 | 3310 | A_23_P114903 | -0.1974 | 0.3710 | |
| SRP064894 | HSPA6 | 3310 | RNAseq | 1.6572 | 0.0000 | |
| SRP133303 | HSPA6 | 3310 | RNAseq | 1.4469 | 0.0000 | |
| SRP159526 | HSPA6 | 3310 | RNAseq | 0.2320 | 0.6848 | |
| SRP193095 | HSPA6 | 3310 | RNAseq | 1.4860 | 0.0000 | |
| TCGA | HSPA6 | 3310 | RNAseq | 0.3497 | 0.0896 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by HSPA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HSPA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HSPA6 | 3310 | 10 | 0 | 20 | |
| GSE20123 | HSPA6 | 3310 | 10 | 0 | 20 | |
| GSE43470 | HSPA6 | 3310 | 7 | 2 | 34 | |
| GSE46452 | HSPA6 | 3310 | 2 | 1 | 56 | |
| GSE47630 | HSPA6 | 3310 | 14 | 0 | 26 | |
| GSE54993 | HSPA6 | 3310 | 0 | 5 | 65 | |
| GSE54994 | HSPA6 | 3310 | 16 | 0 | 37 | |
| GSE60625 | HSPA6 | 3310 | 0 | 0 | 11 | |
| GSE74703 | HSPA6 | 3310 | 7 | 2 | 27 | |
| GSE74704 | HSPA6 | 3310 | 4 | 0 | 16 | |
| TCGA | HSPA6 | 3310 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of HSPA6:
Generating mutation plots.
Highly correlated genes for HSPA6:
Showing top 20/51 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HSPA6 | DTX3 | 0.701049 | 3 | 0 | 3 |
| HSPA6 | CA11 | 0.698939 | 3 | 0 | 3 |
| HSPA6 | USP12 | 0.670972 | 3 | 0 | 3 |
| HSPA6 | PRKCQ | 0.638287 | 3 | 0 | 3 |
| HSPA6 | ABL2 | 0.632917 | 4 | 0 | 4 |
| HSPA6 | PDHX | 0.631646 | 3 | 0 | 3 |
| HSPA6 | GMPR | 0.621369 | 3 | 0 | 3 |
| HSPA6 | NXF1 | 0.616776 | 3 | 0 | 3 |
| HSPA6 | C20orf194 | 0.616413 | 3 | 0 | 3 |
| HSPA6 | CAMK1 | 0.611608 | 3 | 0 | 3 |
| HSPA6 | RNASE1 | 0.606152 | 3 | 0 | 3 |
| HSPA6 | RGMB | 0.602018 | 3 | 0 | 3 |
| HSPA6 | PFKM | 0.601257 | 4 | 0 | 3 |
| HSPA6 | CPA6 | 0.599109 | 3 | 0 | 3 |
| HSPA6 | ZFAND2A | 0.597551 | 5 | 0 | 4 |
| HSPA6 | MRPS6 | 0.588885 | 3 | 0 | 3 |
| HSPA6 | MAP4 | 0.586909 | 3 | 0 | 3 |
| HSPA6 | LRCH2 | 0.586354 | 4 | 0 | 3 |
| HSPA6 | SEC63 | 0.5853 | 3 | 0 | 3 |
| HSPA6 | TMEM71 | 0.580478 | 4 | 0 | 3 |
For details and further investigation, click here
