| Full name: speckle type BTB/POZ protein like | Alias Symbol: BTBD33 | ||
| Type: protein-coding gene | Cytoband: 2q22.1 | ||
| Entrez ID: 339745 | HGNC ID: HGNC:27934 | Ensembl Gene: ENSG00000144228 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
SPOPL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway |
Expression of SPOPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPOPL | 339745 | 225658_at | -0.0835 | 0.9011 | |
| GSE26886 | SPOPL | 339745 | 225658_at | -0.1982 | 0.5255 | |
| GSE45670 | SPOPL | 339745 | 225658_at | -0.2061 | 0.3359 | |
| GSE53622 | SPOPL | 339745 | 122920 | -0.2115 | 0.0224 | |
| GSE53624 | SPOPL | 339745 | 122920 | -0.1337 | 0.1279 | |
| GSE63941 | SPOPL | 339745 | 225658_at | 0.3284 | 0.5300 | |
| GSE77861 | SPOPL | 339745 | 225658_at | 0.7564 | 0.0142 | |
| GSE97050 | SPOPL | 339745 | A_24_P551028 | -0.4803 | 0.2246 | |
| SRP007169 | SPOPL | 339745 | RNAseq | 0.8015 | 0.0207 | |
| SRP008496 | SPOPL | 339745 | RNAseq | 0.7185 | 0.0020 | |
| SRP064894 | SPOPL | 339745 | RNAseq | 0.1174 | 0.6424 | |
| SRP133303 | SPOPL | 339745 | RNAseq | 0.5359 | 0.0015 | |
| SRP159526 | SPOPL | 339745 | RNAseq | 0.2679 | 0.3836 | |
| SRP193095 | SPOPL | 339745 | RNAseq | 0.0263 | 0.8271 | |
| SRP219564 | SPOPL | 339745 | RNAseq | -0.3856 | 0.3294 | |
| TCGA | SPOPL | 339745 | RNAseq | -0.1046 | 0.0912 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPOPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPOPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPOPL | 339745 | 4 | 4 | 22 | |
| GSE20123 | SPOPL | 339745 | 4 | 4 | 22 | |
| GSE43470 | SPOPL | 339745 | 3 | 1 | 39 | |
| GSE46452 | SPOPL | 339745 | 1 | 4 | 54 | |
| GSE47630 | SPOPL | 339745 | 5 | 2 | 33 | |
| GSE54993 | SPOPL | 339745 | 0 | 6 | 64 | |
| GSE54994 | SPOPL | 339745 | 9 | 0 | 44 | |
| GSE60625 | SPOPL | 339745 | 0 | 3 | 8 | |
| GSE74703 | SPOPL | 339745 | 2 | 1 | 33 | |
| GSE74704 | SPOPL | 339745 | 2 | 1 | 17 | |
| TCGA | SPOPL | 339745 | 20 | 11 | 65 |
Total number of gains: 50; Total number of losses: 37; Total Number of normals: 401.
Somatic mutations of SPOPL:
Generating mutation plots.
Highly correlated genes for SPOPL:
Showing top 20/613 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPOPL | USP14 | 0.815455 | 3 | 0 | 3 |
| SPOPL | GATAD1 | 0.789957 | 3 | 0 | 3 |
| SPOPL | RAB23 | 0.783756 | 4 | 0 | 4 |
| SPOPL | MEF2D | 0.78035 | 3 | 0 | 3 |
| SPOPL | DUSP3 | 0.758964 | 3 | 0 | 3 |
| SPOPL | FGF12 | 0.75733 | 3 | 0 | 3 |
| SPOPL | DPF2 | 0.750857 | 3 | 0 | 3 |
| SPOPL | CD99L2 | 0.744445 | 4 | 0 | 4 |
| SPOPL | BCL6 | 0.742279 | 3 | 0 | 3 |
| SPOPL | NUDCD1 | 0.741958 | 3 | 0 | 3 |
| SPOPL | RPS6KC1 | 0.740602 | 3 | 0 | 3 |
| SPOPL | DNM1L | 0.739157 | 3 | 0 | 3 |
| SPOPL | PTPN9 | 0.734993 | 3 | 0 | 3 |
| SPOPL | PSMD4 | 0.734105 | 3 | 0 | 3 |
| SPOPL | TYW3 | 0.733816 | 3 | 0 | 3 |
| SPOPL | CBLL1 | 0.731366 | 3 | 0 | 3 |
| SPOPL | STARD7 | 0.729571 | 3 | 0 | 3 |
| SPOPL | SYNC | 0.724632 | 3 | 0 | 3 |
| SPOPL | COL4A5 | 0.72112 | 4 | 0 | 4 |
| SPOPL | KIAA1328 | 0.719386 | 3 | 0 | 3 |
For details and further investigation, click here
