RAD50

 

Full name: RAD50 double strand break repair protein Alias Symbol: hRad50|RAD50-2
Type: protein-coding gene Cytoband: 5q31.1
Entrez ID: 10111 HGNC ID: HGNC:9816 Ensembl Gene: ENSG00000113522 OMIM ID: 604040
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of RAD50:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAD50 10111 208393_s_at -0.2306 0.6336
GSE20347 RAD50 10111 208393_s_at -0.1462 0.4840
GSE23400 RAD50 10111 208393_s_at 0.2689 0.0002
GSE26886 RAD50 10111 208393_s_at -0.0851 0.7988
GSE29001 RAD50 10111 208393_s_at 0.0735 0.8411
GSE38129 RAD50 10111 208393_s_at 0.1185 0.4333
GSE45670 RAD50 10111 208393_s_at 0.3121 0.0440
GSE53622 RAD50 10111 118183 -0.4460 0.0000
GSE53624 RAD50 10111 118183 -0.0871 0.2875
GSE63941 RAD50 10111 208393_s_at -0.0124 0.9877
GSE77861 RAD50 10111 208393_s_at 0.0031 0.9943
GSE97050 RAD50 10111 A_23_P250404 -0.3440 0.2204
SRP007169 RAD50 10111 RNAseq -0.6838 0.0345
SRP008496 RAD50 10111 RNAseq -0.3332 0.1452
SRP064894 RAD50 10111 RNAseq -0.2580 0.1765
SRP133303 RAD50 10111 RNAseq 0.0689 0.6874
SRP159526 RAD50 10111 RNAseq -0.2753 0.5291
SRP193095 RAD50 10111 RNAseq -0.2049 0.0368
SRP219564 RAD50 10111 RNAseq -0.4925 0.0306
TCGA RAD50 10111 RNAseq -0.1266 0.0075

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by RAD50 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of RAD50:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAD50 10111 1 11 18
GSE20123 RAD50 10111 2 11 17
GSE43470 RAD50 10111 2 9 32
GSE46452 RAD50 10111 0 27 32
GSE47630 RAD50 10111 0 21 19
GSE54993 RAD50 10111 9 1 60
GSE54994 RAD50 10111 2 14 37
GSE60625 RAD50 10111 0 0 11
GSE74703 RAD50 10111 2 6 28
GSE74704 RAD50 10111 1 5 14
TCGA RAD50 10111 3 39 54

Total number of gains: 22; Total number of losses: 144; Total Number of normals: 322.  

 

Somatic mutations of RAD50:

 

Generating mutation plots.

 

Highly correlated genes for RAD50:

 

Showing top 20/410 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAD50LRRC280.753007303
RAD50TM4SF180.746568303
RAD50PTPRG0.746051303
RAD50ZNF354A0.733438303
RAD50TINF20.72665303
RAD50SEC22C0.72394303
RAD50UFL10.718475303
RAD50AGL0.716738404
RAD50COG60.716345303
RAD50FNIP10.711368403
RAD50GNG120.710296403
RAD50C16orf870.709452404
RAD50TTC80.706624303
RAD50NSFL1C0.705298303
RAD50RELL20.703166303
RAD50ZNF3190.702722303
RAD50EHBP10.701044303
RAD50DUSP60.69453303
RAD50SWAP700.693426303
RAD50LARS20.690713303

For details and further investigation, click here