| Full name: interleukin 4 receptor | Alias Symbol: CD124 | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 3566 | HGNC ID: HGNC:6015 | Ensembl Gene: ENSG00000077238 | OMIM ID: 147781 |
| Drug and gene relationship at DGIdb | |||
IL4R involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL4R:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL4R | 3566 | 203233_at | -0.3204 | 0.4578 | |
| GSE20347 | IL4R | 3566 | 203233_at | -0.5080 | 0.0220 | |
| GSE23400 | IL4R | 3566 | 203233_at | -0.2302 | 0.0277 | |
| GSE26886 | IL4R | 3566 | 203233_at | -0.7475 | 0.0076 | |
| GSE29001 | IL4R | 3566 | 203233_at | -0.3533 | 0.2217 | |
| GSE38129 | IL4R | 3566 | 203233_at | -0.5222 | 0.0075 | |
| GSE45670 | IL4R | 3566 | 203233_at | 0.5855 | 0.0084 | |
| GSE53622 | IL4R | 3566 | 68113 | -0.4673 | 0.0000 | |
| GSE53624 | IL4R | 3566 | 1450 | -0.2989 | 0.0001 | |
| GSE63941 | IL4R | 3566 | 203233_at | -1.6993 | 0.0182 | |
| GSE77861 | IL4R | 3566 | 203233_at | 0.0230 | 0.9573 | |
| GSE97050 | IL4R | 3566 | A_33_P3349045 | 0.2797 | 0.4985 | |
| SRP007169 | IL4R | 3566 | RNAseq | -0.3228 | 0.5323 | |
| SRP008496 | IL4R | 3566 | RNAseq | -0.5523 | 0.0778 | |
| SRP064894 | IL4R | 3566 | RNAseq | 0.0763 | 0.6479 | |
| SRP133303 | IL4R | 3566 | RNAseq | 0.2846 | 0.3479 | |
| SRP159526 | IL4R | 3566 | RNAseq | -1.3889 | 0.0000 | |
| SRP193095 | IL4R | 3566 | RNAseq | 0.1196 | 0.4407 | |
| SRP219564 | IL4R | 3566 | RNAseq | -0.6693 | 0.2162 | |
| TCGA | IL4R | 3566 | RNAseq | -0.0378 | 0.6506 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by IL4R expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL4R:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL4R | 3566 | 3 | 5 | 22 | |
| GSE20123 | IL4R | 3566 | 3 | 4 | 23 | |
| GSE43470 | IL4R | 3566 | 4 | 3 | 36 | |
| GSE46452 | IL4R | 3566 | 38 | 1 | 20 | |
| GSE47630 | IL4R | 3566 | 11 | 7 | 22 | |
| GSE54993 | IL4R | 3566 | 3 | 5 | 62 | |
| GSE54994 | IL4R | 3566 | 4 | 9 | 40 | |
| GSE60625 | IL4R | 3566 | 4 | 0 | 7 | |
| GSE74703 | IL4R | 3566 | 4 | 2 | 30 | |
| GSE74704 | IL4R | 3566 | 2 | 2 | 16 | |
| TCGA | IL4R | 3566 | 19 | 12 | 65 |
Total number of gains: 95; Total number of losses: 50; Total Number of normals: 343.
Somatic mutations of IL4R:
Generating mutation plots.
Highly correlated genes for IL4R:
Showing top 20/145 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL4R | DUSP6 | 0.684841 | 3 | 0 | 3 |
| IL4R | ERGIC1 | 0.662133 | 3 | 0 | 3 |
| IL4R | FHOD3 | 0.662121 | 3 | 0 | 3 |
| IL4R | RSPH9 | 0.66175 | 3 | 0 | 3 |
| IL4R | MVP | 0.645862 | 10 | 0 | 9 |
| IL4R | NEK9 | 0.635112 | 3 | 0 | 3 |
| IL4R | USP40 | 0.634829 | 3 | 0 | 3 |
| IL4R | CDIPT | 0.62493 | 3 | 0 | 3 |
| IL4R | KLF10 | 0.624052 | 5 | 0 | 3 |
| IL4R | LDHA | 0.620782 | 4 | 0 | 3 |
| IL4R | GPR68 | 0.620713 | 4 | 0 | 3 |
| IL4R | SLAIN2 | 0.619509 | 3 | 0 | 3 |
| IL4R | AK1 | 0.608478 | 3 | 0 | 3 |
| IL4R | KLHDC8B | 0.603632 | 4 | 0 | 3 |
| IL4R | CHL1 | 0.598625 | 4 | 0 | 3 |
| IL4R | MAP3K8 | 0.598331 | 4 | 0 | 3 |
| IL4R | NFKBIZ | 0.597668 | 7 | 0 | 5 |
| IL4R | IRS1 | 0.593182 | 4 | 0 | 3 |
| IL4R | TMEM234 | 0.589897 | 3 | 0 | 3 |
| IL4R | ITPRIP | 0.589859 | 7 | 0 | 6 |
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