NUP133

 

Full name: nucleoporin 133 Alias Symbol: FLJ10814
Type: protein-coding gene Cytoband: 1q42.13
Entrez ID: 55746 HGNC ID: HGNC:18016 Ensembl Gene: ENSG00000069248 OMIM ID: 607613
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of NUP133:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NUP133 55746 202184_s_at 0.7523 0.0476
GSE20347 NUP133 55746 202184_s_at 0.4133 0.0041
GSE23400 NUP133 55746 202184_s_at 0.4339 0.0000
GSE26886 NUP133 55746 202184_s_at 0.3031 0.1267
GSE29001 NUP133 55746 202184_s_at 0.5551 0.0171
GSE38129 NUP133 55746 202184_s_at 0.5619 0.0000
GSE45670 NUP133 55746 202184_s_at 0.2792 0.0245
GSE53622 NUP133 55746 4035 0.3232 0.0000
GSE53624 NUP133 55746 4035 0.4374 0.0000
GSE63941 NUP133 55746 202184_s_at 0.0753 0.8506
GSE77861 NUP133 55746 202184_s_at 0.4233 0.0702
GSE97050 NUP133 55746 A_33_P3284077 0.1060 0.6290
SRP007169 NUP133 55746 RNAseq 0.0226 0.9472
SRP008496 NUP133 55746 RNAseq 0.1361 0.5541
SRP064894 NUP133 55746 RNAseq 0.1983 0.0753
SRP133303 NUP133 55746 RNAseq 0.3339 0.0125
SRP159526 NUP133 55746 RNAseq 0.3611 0.2982
SRP193095 NUP133 55746 RNAseq 0.2239 0.0185
SRP219564 NUP133 55746 RNAseq 0.0539 0.7978
TCGA NUP133 55746 RNAseq 0.1194 0.0134

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by NUP133 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NUP133:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NUP133 55746 11 0 19
GSE20123 NUP133 55746 11 0 19
GSE43470 NUP133 55746 8 1 34
GSE46452 NUP133 55746 4 2 53
GSE47630 NUP133 55746 15 0 25
GSE54993 NUP133 55746 0 6 64
GSE54994 NUP133 55746 17 0 36
GSE60625 NUP133 55746 0 0 11
GSE74703 NUP133 55746 8 1 27
GSE74704 NUP133 55746 5 0 15
TCGA NUP133 55746 45 2 49

Total number of gains: 124; Total number of losses: 12; Total Number of normals: 352.  

 

Somatic mutations of NUP133:

 

Generating mutation plots.

 

Highly correlated genes for NUP133:

 

Showing top 20/1350 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NUP133DYRK20.784965303
NUP133NOA10.783729303
NUP133PCYT1A0.744409303
NUP133ABCF30.735823404
NUP133SOCS70.735749303
NUP133PIP4K2C0.735528303
NUP133MRPS60.712804303
NUP133COG20.7111171009
NUP133SMCR80.710988403
NUP133GORAB0.710674606
NUP133KLF130.708984303
NUP133STAU10.706535403
NUP133SNRPE0.70377412010
NUP133CHD40.702104403
NUP133HPS30.701921605
NUP133PARP10.70049613012
NUP133SFXN20.698486303
NUP133CAMKK20.697542303
NUP133RNF1210.694541303
NUP133C12orf730.693376404

For details and further investigation, click here