| Full name: dual specificity tyrosine phosphorylation regulated kinase 3 | Alias Symbol: RED|REDK|hYAK3-2 | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 8444 | HGNC ID: HGNC:3094 | Ensembl Gene: ENSG00000143479 | OMIM ID: 603497 |
| Drug and gene relationship at DGIdb | |||
Expression of DYRK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYRK3 | 8444 | 210151_s_at | 0.3404 | 0.3022 | |
| GSE20347 | DYRK3 | 8444 | 210151_s_at | 0.1720 | 0.1035 | |
| GSE23400 | DYRK3 | 8444 | 210151_s_at | 0.0181 | 0.7287 | |
| GSE26886 | DYRK3 | 8444 | 210151_s_at | 0.4118 | 0.0615 | |
| GSE29001 | DYRK3 | 8444 | 210151_s_at | 0.0882 | 0.6562 | |
| GSE38129 | DYRK3 | 8444 | 210151_s_at | 0.1040 | 0.3775 | |
| GSE45670 | DYRK3 | 8444 | 210151_s_at | 0.4088 | 0.0232 | |
| GSE53622 | DYRK3 | 8444 | 21807 | 0.9510 | 0.0000 | |
| GSE53624 | DYRK3 | 8444 | 21807 | 1.2221 | 0.0000 | |
| GSE63941 | DYRK3 | 8444 | 210151_s_at | -0.6752 | 0.1357 | |
| GSE77861 | DYRK3 | 8444 | 210151_s_at | 0.0674 | 0.7212 | |
| GSE97050 | DYRK3 | 8444 | A_24_P345209 | 1.1729 | 0.0959 | |
| SRP007169 | DYRK3 | 8444 | RNAseq | 1.0481 | 0.1582 | |
| SRP008496 | DYRK3 | 8444 | RNAseq | 1.6809 | 0.0001 | |
| SRP064894 | DYRK3 | 8444 | RNAseq | 1.2145 | 0.0000 | |
| SRP133303 | DYRK3 | 8444 | RNAseq | 1.4264 | 0.0000 | |
| SRP159526 | DYRK3 | 8444 | RNAseq | 1.2946 | 0.0000 | |
| SRP193095 | DYRK3 | 8444 | RNAseq | 1.7151 | 0.0000 | |
| SRP219564 | DYRK3 | 8444 | RNAseq | 1.6445 | 0.0280 | |
| TCGA | DYRK3 | 8444 | RNAseq | 0.1373 | 0.1942 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by DYRK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYRK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYRK3 | 8444 | 11 | 0 | 19 | |
| GSE20123 | DYRK3 | 8444 | 11 | 0 | 19 | |
| GSE43470 | DYRK3 | 8444 | 7 | 0 | 36 | |
| GSE46452 | DYRK3 | 8444 | 3 | 1 | 55 | |
| GSE47630 | DYRK3 | 8444 | 14 | 0 | 26 | |
| GSE54993 | DYRK3 | 8444 | 0 | 6 | 64 | |
| GSE54994 | DYRK3 | 8444 | 14 | 0 | 39 | |
| GSE60625 | DYRK3 | 8444 | 0 | 0 | 11 | |
| GSE74703 | DYRK3 | 8444 | 7 | 0 | 29 | |
| GSE74704 | DYRK3 | 8444 | 5 | 0 | 15 | |
| TCGA | DYRK3 | 8444 | 44 | 4 | 48 |
Total number of gains: 116; Total number of losses: 11; Total Number of normals: 361.
Somatic mutations of DYRK3:
Generating mutation plots.
Highly correlated genes for DYRK3:
Showing top 20/759 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYRK3 | LRRC8C | 0.768905 | 3 | 0 | 3 |
| DYRK3 | NEIL2 | 0.759302 | 3 | 0 | 3 |
| DYRK3 | GNG10 | 0.719212 | 3 | 0 | 3 |
| DYRK3 | PANX1 | 0.718124 | 5 | 0 | 5 |
| DYRK3 | CEP170 | 0.707664 | 3 | 0 | 3 |
| DYRK3 | FAM89A | 0.704983 | 3 | 0 | 3 |
| DYRK3 | FCGR3A | 0.701805 | 3 | 0 | 3 |
| DYRK3 | SMARCA5 | 0.700264 | 4 | 0 | 4 |
| DYRK3 | FADS1 | 0.698121 | 3 | 0 | 3 |
| DYRK3 | ABCF1 | 0.696469 | 4 | 0 | 4 |
| DYRK3 | ZNF787 | 0.690142 | 3 | 0 | 3 |
| DYRK3 | FKBP10 | 0.687507 | 4 | 0 | 3 |
| DYRK3 | STARD3NL | 0.68343 | 5 | 0 | 4 |
| DYRK3 | CRLF1 | 0.681913 | 3 | 0 | 3 |
| DYRK3 | SPON2 | 0.681457 | 3 | 0 | 3 |
| DYRK3 | ECI2 | 0.678657 | 3 | 0 | 3 |
| DYRK3 | SSC5D | 0.677533 | 3 | 0 | 3 |
| DYRK3 | AATF | 0.677123 | 4 | 0 | 4 |
| DYRK3 | RAB34 | 0.671666 | 3 | 0 | 3 |
| DYRK3 | ZBTB9 | 0.668349 | 4 | 0 | 3 |
For details and further investigation, click here
