| Full name: apoptosis antagonizing transcription factor | Alias Symbol: DED|CHE-1|CHE1|BFR2 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 26574 | HGNC ID: HGNC:19235 | Ensembl Gene: ENSG00000275700 | OMIM ID: 608463 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of AATF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AATF | 26574 | 209165_at | 0.5152 | 0.0471 | |
| GSE20347 | AATF | 26574 | 209165_at | 0.6681 | 0.0003 | |
| GSE23400 | AATF | 26574 | 209165_at | 0.5163 | 0.0000 | |
| GSE26886 | AATF | 26574 | 209165_at | 0.6178 | 0.0090 | |
| GSE29001 | AATF | 26574 | 209165_at | 0.6247 | 0.0496 | |
| GSE38129 | AATF | 26574 | 209165_at | 0.6220 | 0.0000 | |
| GSE45670 | AATF | 26574 | 209165_at | 0.4303 | 0.0218 | |
| GSE53622 | AATF | 26574 | 16970 | 0.8333 | 0.0000 | |
| GSE53624 | AATF | 26574 | 16970 | 0.9042 | 0.0000 | |
| GSE63941 | AATF | 26574 | 209165_at | 0.9967 | 0.0012 | |
| GSE77861 | AATF | 26574 | 209165_at | 0.9871 | 0.0006 | |
| GSE97050 | AATF | 26574 | A_23_P89460 | 0.8054 | 0.0992 | |
| SRP007169 | AATF | 26574 | RNAseq | 1.6008 | 0.0004 | |
| SRP008496 | AATF | 26574 | RNAseq | 1.1858 | 0.0008 | |
| SRP064894 | AATF | 26574 | RNAseq | 0.8260 | 0.0000 | |
| SRP133303 | AATF | 26574 | RNAseq | 0.7438 | 0.0000 | |
| SRP159526 | AATF | 26574 | RNAseq | 0.5538 | 0.0041 | |
| SRP193095 | AATF | 26574 | RNAseq | 0.6585 | 0.0000 | |
| SRP219564 | AATF | 26574 | RNAseq | 0.5275 | 0.1262 | |
| TCGA | AATF | 26574 | RNAseq | 0.1488 | 0.0027 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by AATF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AATF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AATF | 26574 | 5 | 1 | 24 | |
| GSE20123 | AATF | 26574 | 5 | 1 | 24 | |
| GSE43470 | AATF | 26574 | 0 | 2 | 41 | |
| GSE46452 | AATF | 26574 | 35 | 0 | 24 | |
| GSE47630 | AATF | 26574 | 8 | 1 | 31 | |
| GSE54993 | AATF | 26574 | 3 | 3 | 64 | |
| GSE54994 | AATF | 26574 | 8 | 6 | 39 | |
| GSE60625 | AATF | 26574 | 4 | 0 | 7 | |
| GSE74703 | AATF | 26574 | 0 | 1 | 35 | |
| GSE74704 | AATF | 26574 | 3 | 1 | 16 | |
| TCGA | AATF | 26574 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of AATF:
Generating mutation plots.
Highly correlated genes for AATF:
Showing top 20/2121 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AATF | SLC35B2 | 0.778245 | 3 | 0 | 3 |
| AATF | FAM89A | 0.772705 | 3 | 0 | 3 |
| AATF | PIBF1 | 0.768323 | 3 | 0 | 3 |
| AATF | EFTUD2 | 0.758778 | 8 | 0 | 8 |
| AATF | NF1 | 0.757368 | 3 | 0 | 3 |
| AATF | DKC1 | 0.756491 | 3 | 0 | 3 |
| AATF | EBNA1BP2 | 0.75417 | 3 | 0 | 3 |
| AATF | PSMB3 | 0.753762 | 13 | 0 | 12 |
| AATF | FIP1L1 | 0.749467 | 3 | 0 | 3 |
| AATF | ZNF707 | 0.74819 | 3 | 0 | 3 |
| AATF | STIP1 | 0.747599 | 11 | 0 | 10 |
| AATF | ACLY | 0.747542 | 10 | 0 | 10 |
| AATF | KTI12 | 0.745941 | 3 | 0 | 3 |
| AATF | PSMD3 | 0.74574 | 12 | 0 | 11 |
| AATF | DDX39A | 0.745614 | 12 | 0 | 12 |
| AATF | PTCD1 | 0.744622 | 3 | 0 | 3 |
| AATF | NFKB1 | 0.744597 | 3 | 0 | 3 |
| AATF | MMS22L | 0.742369 | 3 | 0 | 3 |
| AATF | ANAPC1 | 0.741085 | 3 | 0 | 3 |
| AATF | SLC26A6 | 0.737579 | 3 | 0 | 3 |
For details and further investigation, click here
