| Full name: pannexin 1 | Alias Symbol: MRS1|UNQ2529|PX1 | ||
| Type: protein-coding gene | Cytoband: 11q21 | ||
| Entrez ID: 24145 | HGNC ID: HGNC:8599 | Ensembl Gene: ENSG00000110218 | OMIM ID: 608420 |
| Drug and gene relationship at DGIdb | |||
Expression of PANX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PANX1 | 24145 | 227107_at | 0.7434 | 0.2232 | |
| GSE20347 | PANX1 | 24145 | 204715_at | 1.2929 | 0.0016 | |
| GSE23400 | PANX1 | 24145 | 204715_at | 1.0535 | 0.0000 | |
| GSE26886 | PANX1 | 24145 | 227107_at | 0.9832 | 0.0058 | |
| GSE29001 | PANX1 | 24145 | 204715_at | 1.1489 | 0.0014 | |
| GSE38129 | PANX1 | 24145 | 204715_at | 1.2760 | 0.0000 | |
| GSE45670 | PANX1 | 24145 | 227107_at | 0.6940 | 0.0092 | |
| GSE53622 | PANX1 | 24145 | 14291 | 0.9948 | 0.0000 | |
| GSE53624 | PANX1 | 24145 | 14291 | 1.3418 | 0.0000 | |
| GSE63941 | PANX1 | 24145 | 227107_at | -1.9626 | 0.0039 | |
| GSE77861 | PANX1 | 24145 | 227107_at | 0.8359 | 0.0773 | |
| GSE97050 | PANX1 | 24145 | A_33_P3370404 | 0.8009 | 0.0607 | |
| SRP007169 | PANX1 | 24145 | RNAseq | 1.2967 | 0.0009 | |
| SRP008496 | PANX1 | 24145 | RNAseq | 1.7767 | 0.0000 | |
| SRP064894 | PANX1 | 24145 | RNAseq | 1.3195 | 0.0000 | |
| SRP133303 | PANX1 | 24145 | RNAseq | 1.1479 | 0.0000 | |
| SRP159526 | PANX1 | 24145 | RNAseq | 0.8914 | 0.0583 | |
| SRP193095 | PANX1 | 24145 | RNAseq | 0.9970 | 0.0000 | |
| SRP219564 | PANX1 | 24145 | RNAseq | 0.7934 | 0.1052 | |
| TCGA | PANX1 | 24145 | RNAseq | 0.2194 | 0.0035 |
Upregulated datasets: 9; Downregulated datasets: 1.
Survival by PANX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PANX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PANX1 | 24145 | 3 | 9 | 18 | |
| GSE20123 | PANX1 | 24145 | 3 | 9 | 18 | |
| GSE43470 | PANX1 | 24145 | 2 | 5 | 36 | |
| GSE46452 | PANX1 | 24145 | 5 | 24 | 30 | |
| GSE47630 | PANX1 | 24145 | 2 | 19 | 19 | |
| GSE54993 | PANX1 | 24145 | 8 | 2 | 60 | |
| GSE54994 | PANX1 | 24145 | 5 | 19 | 29 | |
| GSE60625 | PANX1 | 24145 | 0 | 3 | 8 | |
| GSE74703 | PANX1 | 24145 | 1 | 4 | 31 | |
| GSE74704 | PANX1 | 24145 | 3 | 5 | 12 | |
| TCGA | PANX1 | 24145 | 11 | 43 | 42 |
Total number of gains: 43; Total number of losses: 142; Total Number of normals: 303.
Somatic mutations of PANX1:
Generating mutation plots.
Highly correlated genes for PANX1:
Showing top 20/1295 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PANX1 | NXN | 0.790106 | 3 | 0 | 3 |
| PANX1 | SPON2 | 0.775423 | 3 | 0 | 3 |
| PANX1 | DNAJC24 | 0.766982 | 3 | 0 | 3 |
| PANX1 | GNG10 | 0.760274 | 3 | 0 | 3 |
| PANX1 | FADS1 | 0.751803 | 3 | 0 | 3 |
| PANX1 | RAB34 | 0.748279 | 3 | 0 | 3 |
| PANX1 | RPL22L1 | 0.726758 | 3 | 0 | 3 |
| PANX1 | DYRK3 | 0.718124 | 5 | 0 | 5 |
| PANX1 | LPCAT1 | 0.717759 | 11 | 0 | 11 |
| PANX1 | DERA | 0.714441 | 3 | 0 | 3 |
| PANX1 | ZNF707 | 0.710898 | 3 | 0 | 3 |
| PANX1 | CCM2 | 0.708647 | 6 | 0 | 6 |
| PANX1 | GLS | 0.705383 | 8 | 0 | 7 |
| PANX1 | ANKRD13C | 0.703275 | 3 | 0 | 3 |
| PANX1 | SLC35B2 | 0.699603 | 3 | 0 | 3 |
| PANX1 | ZBTB2 | 0.695761 | 5 | 0 | 5 |
| PANX1 | LRRC8C | 0.694702 | 4 | 0 | 3 |
| PANX1 | ETV6 | 0.694375 | 3 | 0 | 3 |
| PANX1 | KDSR | 0.693107 | 5 | 0 | 4 |
| PANX1 | SERPINH1 | 0.69147 | 10 | 0 | 10 |
For details and further investigation, click here
