| Full name: E2F transcription factor 1 | Alias Symbol: RBP3 | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 1869 | HGNC ID: HGNC:3113 | Ensembl Gene: ENSG00000101412 | OMIM ID: 189971 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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E2F1 involved pathways:
Expression of E2F1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | E2F1 | 1869 | 204947_at | 0.7850 | 0.1004 | |
| GSE20347 | E2F1 | 1869 | 204947_at | 0.3784 | 0.0000 | |
| GSE23400 | E2F1 | 1869 | 2028_s_at | 0.1867 | 0.0000 | |
| GSE26886 | E2F1 | 1869 | 204947_at | 0.3181 | 0.0188 | |
| GSE29001 | E2F1 | 1869 | 204947_at | 0.9038 | 0.0005 | |
| GSE38129 | E2F1 | 1869 | 204947_at | 0.3587 | 0.0000 | |
| GSE45670 | E2F1 | 1869 | 204947_at | 0.2754 | 0.0066 | |
| GSE53622 | E2F1 | 1869 | 9637 | 0.7099 | 0.0000 | |
| GSE53624 | E2F1 | 1869 | 9637 | 1.0790 | 0.0000 | |
| GSE63941 | E2F1 | 1869 | 204947_at | 0.8653 | 0.0027 | |
| GSE77861 | E2F1 | 1869 | 204947_at | 0.1676 | 0.0991 | |
| GSE97050 | E2F1 | 1869 | A_23_P80032 | 0.4158 | 0.2206 | |
| SRP007169 | E2F1 | 1869 | RNAseq | 0.9634 | 0.1075 | |
| SRP008496 | E2F1 | 1869 | RNAseq | 1.2363 | 0.0068 | |
| SRP064894 | E2F1 | 1869 | RNAseq | 2.0648 | 0.0000 | |
| SRP133303 | E2F1 | 1869 | RNAseq | 1.4433 | 0.0000 | |
| SRP159526 | E2F1 | 1869 | RNAseq | 2.1029 | 0.0000 | |
| SRP193095 | E2F1 | 1869 | RNAseq | 1.4036 | 0.0000 | |
| SRP219564 | E2F1 | 1869 | RNAseq | 2.2478 | 0.0000 | |
| TCGA | E2F1 | 1869 | RNAseq | 0.6582 | 0.0000 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by E2F1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of E2F1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | E2F1 | 1869 | 15 | 0 | 15 | |
| GSE20123 | E2F1 | 1869 | 15 | 0 | 15 | |
| GSE43470 | E2F1 | 1869 | 12 | 0 | 31 | |
| GSE46452 | E2F1 | 1869 | 29 | 0 | 30 | |
| GSE47630 | E2F1 | 1869 | 24 | 1 | 15 | |
| GSE54993 | E2F1 | 1869 | 0 | 19 | 51 | |
| GSE54994 | E2F1 | 1869 | 25 | 1 | 27 | |
| GSE60625 | E2F1 | 1869 | 0 | 0 | 11 | |
| GSE74703 | E2F1 | 1869 | 11 | 0 | 25 | |
| GSE74704 | E2F1 | 1869 | 10 | 0 | 10 | |
| TCGA | E2F1 | 1869 | 51 | 1 | 44 |
Total number of gains: 192; Total number of losses: 22; Total Number of normals: 274.
Somatic mutations of E2F1:
Generating mutation plots.
Highly correlated genes for E2F1:
Showing top 20/654 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| E2F1 | LRWD1 | 0.778915 | 3 | 0 | 3 |
| E2F1 | SMPD4 | 0.749352 | 3 | 0 | 3 |
| E2F1 | MEI1 | 0.746893 | 3 | 0 | 3 |
| E2F1 | ARL8A | 0.729959 | 3 | 0 | 3 |
| E2F1 | MS4A18 | 0.715318 | 3 | 0 | 3 |
| E2F1 | CEMP1 | 0.714879 | 3 | 0 | 3 |
| E2F1 | NAT8B | 0.706208 | 3 | 0 | 3 |
| E2F1 | SNORA71A | 0.704777 | 3 | 0 | 3 |
| E2F1 | SP8 | 0.701837 | 4 | 0 | 3 |
| E2F1 | IFITM5 | 0.697053 | 3 | 0 | 3 |
| E2F1 | MYBL2 | 0.695975 | 11 | 0 | 11 |
| E2F1 | PRKRIP1 | 0.686629 | 3 | 0 | 3 |
| E2F1 | ADRA1B | 0.684984 | 3 | 0 | 3 |
| E2F1 | ADAP1 | 0.683975 | 4 | 0 | 3 |
| E2F1 | PPIP5K1 | 0.679971 | 3 | 0 | 3 |
| E2F1 | BOP1 | 0.679912 | 3 | 0 | 3 |
| E2F1 | ZDHHC8 | 0.678604 | 7 | 0 | 6 |
| E2F1 | NECAB3 | 0.677152 | 6 | 0 | 6 |
| E2F1 | C19orf48 | 0.673064 | 3 | 0 | 3 |
| E2F1 | HAGHL | 0.672733 | 5 | 0 | 5 |
For details and further investigation, click here
