| Full name: BOP1 ribosomal biogenesis factor | Alias Symbol: KIAA0124 | ||
| Type: protein-coding gene | Cytoband: 8q24.3 | ||
| Entrez ID: 23246 | HGNC ID: HGNC:15519 | Ensembl Gene: ENSG00000261236 | OMIM ID: 610596 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of BOP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | BOP1 | 23246 | 55880 | 0.8917 | 0.0000 | |
| GSE53624 | BOP1 | 23246 | 55880 | 1.1759 | 0.0000 | |
| GSE97050 | BOP1 | 23246 | A_23_P43800 | 0.9023 | 0.1349 | |
| SRP007169 | BOP1 | 23246 | RNAseq | 0.5980 | 0.0928 | |
| SRP008496 | BOP1 | 23246 | RNAseq | 0.6066 | 0.0019 | |
| SRP064894 | BOP1 | 23246 | RNAseq | 1.4773 | 0.0000 | |
| SRP133303 | BOP1 | 23246 | RNAseq | 0.9693 | 0.0000 | |
| SRP159526 | BOP1 | 23246 | RNAseq | 1.0740 | 0.0079 | |
| SRP193095 | BOP1 | 23246 | RNAseq | 1.1114 | 0.0000 | |
| SRP219564 | BOP1 | 23246 | RNAseq | 1.5283 | 0.0095 | |
| TCGA | BOP1 | 23246 | RNAseq | 0.7678 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by BOP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BOP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BOP1 | 23246 | 17 | 1 | 12 | |
| GSE20123 | BOP1 | 23246 | 17 | 1 | 12 | |
| GSE43470 | BOP1 | 23246 | 16 | 2 | 25 | |
| GSE46452 | BOP1 | 23246 | 28 | 0 | 31 | |
| GSE47630 | BOP1 | 23246 | 25 | 1 | 14 | |
| GSE54993 | BOP1 | 23246 | 0 | 25 | 45 | |
| GSE54994 | BOP1 | 23246 | 39 | 1 | 13 | |
| GSE60625 | BOP1 | 23246 | 3 | 4 | 4 | |
| GSE74703 | BOP1 | 23246 | 14 | 1 | 21 | |
| GSE74704 | BOP1 | 23246 | 10 | 0 | 10 | |
| TCGA | BOP1 | 23246 | 63 | 2 | 31 |
Total number of gains: 232; Total number of losses: 38; Total Number of normals: 218.
Somatic mutations of BOP1:
Generating mutation plots.
Highly correlated genes for BOP1:
Showing top 20/232 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BOP1 | DLGAP5 | 0.832064 | 3 | 0 | 3 |
| BOP1 | EXO1 | 0.831158 | 3 | 0 | 3 |
| BOP1 | ECE2 | 0.79789 | 3 | 0 | 3 |
| BOP1 | LRR1 | 0.789278 | 3 | 0 | 3 |
| BOP1 | MCM2 | 0.781504 | 3 | 0 | 3 |
| BOP1 | KIF4A | 0.779271 | 3 | 0 | 3 |
| BOP1 | FOXM1 | 0.776801 | 3 | 0 | 3 |
| BOP1 | BYSL | 0.776465 | 3 | 0 | 3 |
| BOP1 | MYBBP1A | 0.774606 | 3 | 0 | 3 |
| BOP1 | GPRIN1 | 0.773679 | 3 | 0 | 3 |
| BOP1 | CBX3 | 0.770478 | 3 | 0 | 3 |
| BOP1 | GINS2 | 0.76686 | 3 | 0 | 3 |
| BOP1 | TOP1MT | 0.766239 | 3 | 0 | 3 |
| BOP1 | MCM7 | 0.765836 | 3 | 0 | 3 |
| BOP1 | FANCG | 0.765435 | 3 | 0 | 3 |
| BOP1 | RNASEH2A | 0.764666 | 3 | 0 | 3 |
| BOP1 | TK1 | 0.763712 | 3 | 0 | 3 |
| BOP1 | ASF1B | 0.761538 | 3 | 0 | 3 |
| BOP1 | TARBP2 | 0.760116 | 3 | 0 | 3 |
| BOP1 | ATAD3C | 0.758469 | 3 | 0 | 3 |
For details and further investigation, click here
