| Full name: endothelin 2 | Alias Symbol: ET2 | ||
| Type: protein-coding gene | Cytoband: 1p34.2 | ||
| Entrez ID: 1907 | HGNC ID: HGNC:3177 | Ensembl Gene: ENSG00000127129 | OMIM ID: 131241 |
| Drug and gene relationship at DGIdb | |||
Expression of EDN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EDN2 | 1907 | 206758_at | 0.5420 | 0.4574 | |
| GSE20347 | EDN2 | 1907 | 206758_at | 0.1032 | 0.4528 | |
| GSE23400 | EDN2 | 1907 | 206758_at | 0.0279 | 0.7297 | |
| GSE26886 | EDN2 | 1907 | 206758_at | 0.1765 | 0.7272 | |
| GSE29001 | EDN2 | 1907 | 206758_at | 0.0424 | 0.8563 | |
| GSE38129 | EDN2 | 1907 | 206758_at | 0.2789 | 0.0365 | |
| GSE45670 | EDN2 | 1907 | 206758_at | -0.1474 | 0.5652 | |
| GSE53622 | EDN2 | 1907 | 39797 | 0.0475 | 0.9160 | |
| GSE53624 | EDN2 | 1907 | 20132 | -0.2673 | 0.2911 | |
| GSE63941 | EDN2 | 1907 | 206758_at | 0.1898 | 0.4576 | |
| GSE77861 | EDN2 | 1907 | 206758_at | -0.1274 | 0.4662 | |
| SRP133303 | EDN2 | 1907 | RNAseq | 1.1844 | 0.2445 | |
| SRP159526 | EDN2 | 1907 | RNAseq | -0.3105 | 0.7000 | |
| SRP193095 | EDN2 | 1907 | RNAseq | 0.1637 | 0.7525 | |
| SRP219564 | EDN2 | 1907 | RNAseq | 1.7113 | 0.0660 | |
| TCGA | EDN2 | 1907 | RNAseq | 0.7114 | 0.0505 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EDN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EDN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EDN2 | 1907 | 3 | 4 | 23 | |
| GSE20123 | EDN2 | 1907 | 2 | 3 | 25 | |
| GSE43470 | EDN2 | 1907 | 7 | 2 | 34 | |
| GSE46452 | EDN2 | 1907 | 3 | 1 | 55 | |
| GSE47630 | EDN2 | 1907 | 9 | 2 | 29 | |
| GSE54993 | EDN2 | 1907 | 0 | 1 | 69 | |
| GSE54994 | EDN2 | 1907 | 13 | 2 | 38 | |
| GSE60625 | EDN2 | 1907 | 0 | 0 | 11 | |
| GSE74703 | EDN2 | 1907 | 6 | 1 | 29 | |
| GSE74704 | EDN2 | 1907 | 1 | 0 | 19 | |
| TCGA | EDN2 | 1907 | 14 | 16 | 66 |
Total number of gains: 58; Total number of losses: 32; Total Number of normals: 398.
Somatic mutations of EDN2:
Generating mutation plots.
Highly correlated genes for EDN2:
Showing top 20/45 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EDN2 | CEMP1 | 0.68998 | 3 | 0 | 3 |
| EDN2 | IGLL1 | 0.68316 | 3 | 0 | 3 |
| EDN2 | PRSS50 | 0.68281 | 3 | 0 | 3 |
| EDN2 | HTR6 | 0.681542 | 3 | 0 | 3 |
| EDN2 | AMBP | 0.676391 | 3 | 0 | 3 |
| EDN2 | PNOC | 0.669964 | 3 | 0 | 3 |
| EDN2 | COLEC10 | 0.669529 | 3 | 0 | 3 |
| EDN2 | C4BPA | 0.665118 | 4 | 0 | 3 |
| EDN2 | FAIM2 | 0.627412 | 3 | 0 | 3 |
| EDN2 | OPRD1 | 0.606944 | 3 | 0 | 3 |
| EDN2 | CLCNKB | 0.606034 | 4 | 0 | 3 |
| EDN2 | RAB39B | 0.599099 | 3 | 0 | 3 |
| EDN2 | NTN3 | 0.594175 | 4 | 0 | 3 |
| EDN2 | ST8SIA5 | 0.593499 | 3 | 0 | 3 |
| EDN2 | FCHO1 | 0.588428 | 3 | 0 | 3 |
| EDN2 | TNFSF18 | 0.585591 | 3 | 0 | 3 |
| EDN2 | OR2J2 | 0.581948 | 4 | 0 | 3 |
| EDN2 | KCNA4 | 0.580478 | 4 | 0 | 3 |
| EDN2 | RGS6 | 0.576879 | 3 | 0 | 3 |
| EDN2 | CDHR5 | 0.576662 | 3 | 0 | 3 |
For details and further investigation, click here
