| Full name: TNF superfamily member 18 | Alias Symbol: AITRL|TL6|hGITRL | ||
| Type: protein-coding gene | Cytoband: 1q25.1 | ||
| Entrez ID: 8995 | HGNC ID: HGNC:11932 | Ensembl Gene: ENSG00000120337 | OMIM ID: 603898 |
| Drug and gene relationship at DGIdb | |||
Expression of TNFSF18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TNFSF18 | 8995 | 221371_at | 0.1374 | 0.7325 | |
| GSE20347 | TNFSF18 | 8995 | 221371_at | 0.1852 | 0.0262 | |
| GSE23400 | TNFSF18 | 8995 | 221371_at | 0.0528 | 0.4171 | |
| GSE26886 | TNFSF18 | 8995 | 221371_at | 0.2399 | 0.0358 | |
| GSE29001 | TNFSF18 | 8995 | 221371_at | 0.0469 | 0.7884 | |
| GSE38129 | TNFSF18 | 8995 | 221371_at | 0.1062 | 0.1884 | |
| GSE45670 | TNFSF18 | 8995 | 221371_at | 0.4265 | 0.1242 | |
| GSE53622 | TNFSF18 | 8995 | 73970 | 0.5059 | 0.1378 | |
| GSE53624 | TNFSF18 | 8995 | 73970 | 0.5406 | 0.0436 | |
| GSE63941 | TNFSF18 | 8995 | 221371_at | -0.0451 | 0.9611 | |
| GSE77861 | TNFSF18 | 8995 | 221371_at | 0.2210 | 0.2798 | |
| TCGA | TNFSF18 | 8995 | RNAseq | 1.4836 | 0.0207 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TNFSF18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TNFSF18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TNFSF18 | 8995 | 13 | 0 | 17 | |
| GSE20123 | TNFSF18 | 8995 | 13 | 0 | 17 | |
| GSE43470 | TNFSF18 | 8995 | 7 | 2 | 34 | |
| GSE46452 | TNFSF18 | 8995 | 3 | 1 | 55 | |
| GSE47630 | TNFSF18 | 8995 | 14 | 0 | 26 | |
| GSE54993 | TNFSF18 | 8995 | 0 | 6 | 64 | |
| GSE54994 | TNFSF18 | 8995 | 16 | 0 | 37 | |
| GSE60625 | TNFSF18 | 8995 | 0 | 0 | 11 | |
| GSE74703 | TNFSF18 | 8995 | 7 | 2 | 27 | |
| GSE74704 | TNFSF18 | 8995 | 6 | 0 | 14 | |
| TCGA | TNFSF18 | 8995 | 41 | 3 | 52 |
Total number of gains: 120; Total number of losses: 14; Total Number of normals: 354.
Somatic mutations of TNFSF18:
Generating mutation plots.
Highly correlated genes for TNFSF18:
Showing top 20/163 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TNFSF18 | KIR2DL5A | 0.709687 | 4 | 0 | 4 |
| TNFSF18 | GLP1R | 0.659208 | 4 | 0 | 4 |
| TNFSF18 | EPX | 0.657479 | 4 | 0 | 4 |
| TNFSF18 | HMGXB3 | 0.639518 | 3 | 0 | 3 |
| TNFSF18 | SOAT2 | 0.637787 | 3 | 0 | 3 |
| TNFSF18 | GML | 0.626822 | 4 | 0 | 4 |
| TNFSF18 | MYL1 | 0.625912 | 3 | 0 | 3 |
| TNFSF18 | APLP1 | 0.625197 | 3 | 0 | 3 |
| TNFSF18 | HECW1 | 0.623421 | 4 | 0 | 4 |
| TNFSF18 | POU3F4 | 0.616093 | 5 | 0 | 5 |
| TNFSF18 | CELF3 | 0.61484 | 4 | 0 | 4 |
| TNFSF18 | IL13 | 0.614059 | 4 | 0 | 3 |
| TNFSF18 | DOC2A | 0.612793 | 4 | 0 | 3 |
| TNFSF18 | CLCA1 | 0.61082 | 4 | 0 | 3 |
| TNFSF18 | ADD2 | 0.609174 | 3 | 0 | 3 |
| TNFSF18 | OR10H1 | 0.608343 | 4 | 0 | 4 |
| TNFSF18 | CEACAM4 | 0.605389 | 5 | 0 | 4 |
| TNFSF18 | GABRD | 0.604304 | 4 | 0 | 3 |
| TNFSF18 | DBP | 0.602552 | 3 | 0 | 3 |
| TNFSF18 | CENPO | 0.60108 | 5 | 0 | 4 |
For details and further investigation, click here
