| Full name: ephrin A5 | Alias Symbol: AF1|LERK7 | ||
| Type: protein-coding gene | Cytoband: 5q21.3 | ||
| Entrez ID: 1946 | HGNC ID: HGNC:3225 | Ensembl Gene: ENSG00000184349 | OMIM ID: 601535 |
| Drug and gene relationship at DGIdb | |||
EFNA5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04360 | Axon guidance |
Expression of EFNA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EFNA5 | 1946 | 227955_s_at | -1.1011 | 0.4632 | |
| GSE20347 | EFNA5 | 1946 | 214036_at | -0.5624 | 0.0000 | |
| GSE23400 | EFNA5 | 1946 | 214036_at | -0.3795 | 0.0000 | |
| GSE26886 | EFNA5 | 1946 | 227955_s_at | -1.8263 | 0.0015 | |
| GSE29001 | EFNA5 | 1946 | 214036_at | -0.7051 | 0.0623 | |
| GSE38129 | EFNA5 | 1946 | 214036_at | -0.5252 | 0.0001 | |
| GSE45670 | EFNA5 | 1946 | 227955_s_at | -0.8222 | 0.0178 | |
| GSE53622 | EFNA5 | 1946 | 69952 | -0.7994 | 0.0000 | |
| GSE53624 | EFNA5 | 1946 | 127915 | -1.3811 | 0.0000 | |
| GSE63941 | EFNA5 | 1946 | 233814_at | 2.2866 | 0.0257 | |
| GSE77861 | EFNA5 | 1946 | 214036_at | -0.1253 | 0.6273 | |
| GSE97050 | EFNA5 | 1946 | A_23_P167497 | 0.1421 | 0.6647 | |
| SRP007169 | EFNA5 | 1946 | RNAseq | -0.9337 | 0.1215 | |
| SRP008496 | EFNA5 | 1946 | RNAseq | -1.2226 | 0.0008 | |
| SRP064894 | EFNA5 | 1946 | RNAseq | -0.7164 | 0.0164 | |
| SRP133303 | EFNA5 | 1946 | RNAseq | -0.9762 | 0.0000 | |
| SRP159526 | EFNA5 | 1946 | RNAseq | -1.1918 | 0.0066 | |
| SRP193095 | EFNA5 | 1946 | RNAseq | -1.2083 | 0.0000 | |
| SRP219564 | EFNA5 | 1946 | RNAseq | -0.5154 | 0.3857 | |
| TCGA | EFNA5 | 1946 | RNAseq | -0.0763 | 0.5914 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by EFNA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EFNA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EFNA5 | 1946 | 1 | 13 | 16 | |
| GSE20123 | EFNA5 | 1946 | 1 | 13 | 16 | |
| GSE43470 | EFNA5 | 1946 | 3 | 10 | 30 | |
| GSE46452 | EFNA5 | 1946 | 0 | 28 | 31 | |
| GSE47630 | EFNA5 | 1946 | 0 | 20 | 20 | |
| GSE54993 | EFNA5 | 1946 | 9 | 1 | 60 | |
| GSE54994 | EFNA5 | 1946 | 1 | 17 | 35 | |
| GSE60625 | EFNA5 | 1946 | 0 | 0 | 11 | |
| GSE74703 | EFNA5 | 1946 | 2 | 8 | 26 | |
| GSE74704 | EFNA5 | 1946 | 1 | 7 | 12 | |
| TCGA | EFNA5 | 1946 | 3 | 46 | 47 |
Total number of gains: 21; Total number of losses: 163; Total Number of normals: 304.
Somatic mutations of EFNA5:
Generating mutation plots.
Highly correlated genes for EFNA5:
Showing top 20/731 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EFNA5 | NCCRP1 | 0.739109 | 3 | 0 | 3 |
| EFNA5 | SDCBP2 | 0.72394 | 3 | 0 | 3 |
| EFNA5 | S100A14 | 0.687608 | 10 | 0 | 9 |
| EFNA5 | A2ML1 | 0.685238 | 6 | 0 | 6 |
| EFNA5 | ANXA1 | 0.682193 | 8 | 0 | 7 |
| EFNA5 | PRSS27 | 0.677996 | 7 | 0 | 7 |
| EFNA5 | CAPNS2 | 0.676919 | 3 | 0 | 3 |
| EFNA5 | PADI1 | 0.676778 | 7 | 0 | 6 |
| EFNA5 | RAET1E | 0.676054 | 7 | 0 | 7 |
| EFNA5 | SPINK7 | 0.675377 | 6 | 0 | 6 |
| EFNA5 | SPATA19 | 0.673077 | 3 | 0 | 3 |
| EFNA5 | EXOSC7 | 0.670606 | 4 | 0 | 4 |
| EFNA5 | FAM163B | 0.670381 | 3 | 0 | 3 |
| EFNA5 | VPS25 | 0.67034 | 3 | 0 | 3 |
| EFNA5 | VSIG10L | 0.66974 | 6 | 0 | 6 |
| EFNA5 | BNIPL | 0.668888 | 6 | 0 | 6 |
| EFNA5 | IQCF1 | 0.668603 | 3 | 0 | 3 |
| EFNA5 | PRSS1 | 0.667982 | 3 | 0 | 3 |
| EFNA5 | MUC22 | 0.667361 | 3 | 0 | 3 |
| EFNA5 | UPK3B | 0.6663 | 3 | 0 | 3 |
For details and further investigation, click here
