| Full name: ubiquitin protein ligase E3B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q24.11 | ||
| Entrez ID: 89910 | HGNC ID: HGNC:13478 | Ensembl Gene: ENSG00000151148 | OMIM ID: 608047 |
| Drug and gene relationship at DGIdb | |||
Expression of UBE3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE3B | 89910 | 212403_at | 0.1531 | 0.7080 | |
| GSE20347 | UBE3B | 89910 | 212403_at | -0.3864 | 0.0007 | |
| GSE23400 | UBE3B | 89910 | 212403_at | -0.1258 | 0.0155 | |
| GSE26886 | UBE3B | 89910 | 213822_s_at | 0.0199 | 0.9640 | |
| GSE29001 | UBE3B | 89910 | 213822_s_at | -0.1806 | 0.5159 | |
| GSE38129 | UBE3B | 89910 | 212403_at | -0.2564 | 0.0415 | |
| GSE45670 | UBE3B | 89910 | 212403_at | 0.1592 | 0.1504 | |
| GSE53622 | UBE3B | 89910 | 142767 | -0.1621 | 0.0095 | |
| GSE53624 | UBE3B | 89910 | 142767 | -0.1084 | 0.0776 | |
| GSE63941 | UBE3B | 89910 | 212403_at | -0.1064 | 0.7508 | |
| GSE77861 | UBE3B | 89910 | 212403_at | -0.0131 | 0.9593 | |
| GSE97050 | UBE3B | 89910 | A_33_P3258008 | -0.1702 | 0.4324 | |
| SRP007169 | UBE3B | 89910 | RNAseq | -0.5936 | 0.1197 | |
| SRP008496 | UBE3B | 89910 | RNAseq | -0.5042 | 0.0753 | |
| SRP064894 | UBE3B | 89910 | RNAseq | -0.3042 | 0.0153 | |
| SRP133303 | UBE3B | 89910 | RNAseq | -0.1447 | 0.3420 | |
| SRP159526 | UBE3B | 89910 | RNAseq | -0.5389 | 0.0108 | |
| SRP193095 | UBE3B | 89910 | RNAseq | -0.3026 | 0.0000 | |
| SRP219564 | UBE3B | 89910 | RNAseq | -0.7254 | 0.0029 | |
| TCGA | UBE3B | 89910 | RNAseq | -0.0931 | 0.0403 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBE3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE3B | 89910 | 5 | 3 | 22 | |
| GSE20123 | UBE3B | 89910 | 5 | 4 | 21 | |
| GSE43470 | UBE3B | 89910 | 2 | 1 | 40 | |
| GSE46452 | UBE3B | 89910 | 9 | 1 | 49 | |
| GSE47630 | UBE3B | 89910 | 9 | 1 | 30 | |
| GSE54993 | UBE3B | 89910 | 0 | 5 | 65 | |
| GSE54994 | UBE3B | 89910 | 4 | 3 | 46 | |
| GSE60625 | UBE3B | 89910 | 0 | 0 | 11 | |
| GSE74703 | UBE3B | 89910 | 2 | 0 | 34 | |
| GSE74704 | UBE3B | 89910 | 2 | 2 | 16 | |
| TCGA | UBE3B | 89910 | 22 | 9 | 65 |
Total number of gains: 60; Total number of losses: 29; Total Number of normals: 399.
Somatic mutations of UBE3B:
Generating mutation plots.
Highly correlated genes for UBE3B:
Showing top 20/144 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE3B | GET4 | 0.750098 | 3 | 0 | 3 |
| UBE3B | THRAP3 | 0.746034 | 3 | 0 | 3 |
| UBE3B | FLYWCH2 | 0.730536 | 3 | 0 | 3 |
| UBE3B | C5orf51 | 0.722338 | 3 | 0 | 3 |
| UBE3B | RABGAP1 | 0.704221 | 3 | 0 | 3 |
| UBE3B | KAT7 | 0.704013 | 3 | 0 | 3 |
| UBE3B | EIF2B1 | 0.703232 | 3 | 0 | 3 |
| UBE3B | HOXA4 | 0.696829 | 3 | 0 | 3 |
| UBE3B | CHD4 | 0.689335 | 3 | 0 | 3 |
| UBE3B | PBX2 | 0.687729 | 4 | 0 | 4 |
| UBE3B | GOLPH3 | 0.686884 | 3 | 0 | 3 |
| UBE3B | LNP1 | 0.681497 | 3 | 0 | 3 |
| UBE3B | GPBP1L1 | 0.680866 | 4 | 0 | 4 |
| UBE3B | PPP2R5C | 0.675052 | 3 | 0 | 3 |
| UBE3B | ZFYVE9 | 0.671648 | 4 | 0 | 3 |
| UBE3B | KIF13B | 0.665928 | 4 | 0 | 4 |
| UBE3B | GAS7 | 0.66513 | 3 | 0 | 3 |
| UBE3B | LETM2 | 0.663934 | 3 | 0 | 3 |
| UBE3B | GRIN2D | 0.655547 | 3 | 0 | 3 |
| UBE3B | PIP4K2C | 0.651182 | 3 | 0 | 3 |
For details and further investigation, click here
