| Full name: eukaryotic translation initiation factor 2B subunit delta | Alias Symbol: EIF2Bdelta|EIF-2B|DKFZP586J0119|EIF2B | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 8890 | HGNC ID: HGNC:3260 | Ensembl Gene: ENSG00000115211 | OMIM ID: 606687 |
| Drug and gene relationship at DGIdb | |||
Expression of EIF2B4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2B4 | 8890 | 209429_x_at | -0.2352 | 0.4476 | |
| GSE20347 | EIF2B4 | 8890 | 215482_s_at | -0.5809 | 0.0001 | |
| GSE23400 | EIF2B4 | 8890 | 215482_s_at | -0.2615 | 0.0000 | |
| GSE26886 | EIF2B4 | 8890 | 209429_x_at | -0.6513 | 0.0007 | |
| GSE29001 | EIF2B4 | 8890 | 209429_x_at | -0.6125 | 0.0015 | |
| GSE38129 | EIF2B4 | 8890 | 215482_s_at | -0.3929 | 0.0006 | |
| GSE45670 | EIF2B4 | 8890 | 215482_s_at | -0.1858 | 0.1550 | |
| GSE53622 | EIF2B4 | 8890 | 18522 | -0.3627 | 0.0000 | |
| GSE53624 | EIF2B4 | 8890 | 18522 | -0.6776 | 0.0000 | |
| GSE63941 | EIF2B4 | 8890 | 215482_s_at | -0.3185 | 0.3840 | |
| GSE77861 | EIF2B4 | 8890 | 209429_x_at | -0.3422 | 0.0499 | |
| GSE97050 | EIF2B4 | 8890 | A_23_P154058 | -0.3210 | 0.2316 | |
| SRP007169 | EIF2B4 | 8890 | RNAseq | -1.8139 | 0.0000 | |
| SRP008496 | EIF2B4 | 8890 | RNAseq | -1.6420 | 0.0000 | |
| SRP064894 | EIF2B4 | 8890 | RNAseq | -0.2171 | 0.1801 | |
| SRP133303 | EIF2B4 | 8890 | RNAseq | -0.3814 | 0.0017 | |
| SRP159526 | EIF2B4 | 8890 | RNAseq | -0.2290 | 0.4285 | |
| SRP193095 | EIF2B4 | 8890 | RNAseq | -0.4641 | 0.0000 | |
| SRP219564 | EIF2B4 | 8890 | RNAseq | -0.3686 | 0.1569 | |
| TCGA | EIF2B4 | 8890 | RNAseq | -0.0865 | 0.0856 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by EIF2B4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2B4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2B4 | 8890 | 11 | 2 | 17 | |
| GSE20123 | EIF2B4 | 8890 | 11 | 2 | 17 | |
| GSE43470 | EIF2B4 | 8890 | 3 | 1 | 39 | |
| GSE46452 | EIF2B4 | 8890 | 2 | 4 | 53 | |
| GSE47630 | EIF2B4 | 8890 | 8 | 0 | 32 | |
| GSE54993 | EIF2B4 | 8890 | 0 | 6 | 64 | |
| GSE54994 | EIF2B4 | 8890 | 10 | 0 | 43 | |
| GSE60625 | EIF2B4 | 8890 | 0 | 3 | 8 | |
| GSE74703 | EIF2B4 | 8890 | 3 | 0 | 33 | |
| GSE74704 | EIF2B4 | 8890 | 9 | 1 | 10 | |
| TCGA | EIF2B4 | 8890 | 37 | 2 | 57 |
Total number of gains: 94; Total number of losses: 21; Total Number of normals: 373.
Somatic mutations of EIF2B4:
Generating mutation plots.
Highly correlated genes for EIF2B4:
Showing top 20/1160 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2B4 | NAA20 | 0.853171 | 3 | 0 | 3 |
| EIF2B4 | OXNAD1 | 0.835825 | 3 | 0 | 3 |
| EIF2B4 | LRRC28 | 0.766809 | 4 | 0 | 4 |
| EIF2B4 | GMPPB | 0.754984 | 3 | 0 | 3 |
| EIF2B4 | WDR73 | 0.749723 | 3 | 0 | 3 |
| EIF2B4 | PITHD1 | 0.747045 | 5 | 0 | 5 |
| EIF2B4 | ZNF844 | 0.7401 | 3 | 0 | 3 |
| EIF2B4 | CCNYL1 | 0.732511 | 4 | 0 | 4 |
| EIF2B4 | HDHD2 | 0.731608 | 4 | 0 | 3 |
| EIF2B4 | ZNF717 | 0.724208 | 4 | 0 | 4 |
| EIF2B4 | NSRP1 | 0.723643 | 4 | 0 | 4 |
| EIF2B4 | ARGLU1 | 0.722039 | 3 | 0 | 3 |
| EIF2B4 | SLAIN2 | 0.720933 | 5 | 0 | 5 |
| EIF2B4 | ZNF273 | 0.71534 | 3 | 0 | 3 |
| EIF2B4 | ALKBH7 | 0.71388 | 4 | 0 | 4 |
| EIF2B4 | GPR108 | 0.711942 | 3 | 0 | 3 |
| EIF2B4 | KCTD21 | 0.709747 | 5 | 0 | 5 |
| EIF2B4 | HIPK3 | 0.70952 | 3 | 0 | 3 |
| EIF2B4 | PPT2 | 0.701262 | 3 | 0 | 3 |
| EIF2B4 | NFU1 | 0.701254 | 3 | 0 | 3 |
For details and further investigation, click here
