| Full name: palmitoyl-protein thioesterase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 9374 | HGNC ID: HGNC:9326 | Ensembl Gene: ENSG00000221988 | OMIM ID: 603298 |
| Drug and gene relationship at DGIdb | |||
Expression of PPT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | PPT2 | 9374 | 22350 | -0.3909 | 0.0028 | |
| GSE53624 | PPT2 | 9374 | 22350 | -0.3681 | 0.0001 | |
| GSE97050 | PPT2 | 9374 | A_23_P42116 | 0.2709 | 0.3319 | |
| SRP007169 | PPT2 | 9374 | RNAseq | -1.4721 | 0.0032 | |
| SRP008496 | PPT2 | 9374 | RNAseq | -1.5857 | 0.0000 | |
| SRP064894 | PPT2 | 9374 | RNAseq | -0.6617 | 0.0001 | |
| SRP133303 | PPT2 | 9374 | RNAseq | -1.0624 | 0.0000 | |
| SRP159526 | PPT2 | 9374 | RNAseq | -0.5538 | 0.0600 | |
| SRP193095 | PPT2 | 9374 | RNAseq | -0.9697 | 0.0000 | |
| SRP219564 | PPT2 | 9374 | RNAseq | -0.4170 | 0.3338 | |
| TCGA | PPT2 | 9374 | RNAseq | -0.2058 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by PPT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPT2 | 9374 | 5 | 1 | 24 | |
| GSE20123 | PPT2 | 9374 | 5 | 1 | 24 | |
| GSE43470 | PPT2 | 9374 | 5 | 1 | 37 | |
| GSE46452 | PPT2 | 9374 | 1 | 10 | 48 | |
| GSE47630 | PPT2 | 9374 | 7 | 4 | 29 | |
| GSE54993 | PPT2 | 9374 | 2 | 1 | 67 | |
| GSE54994 | PPT2 | 9374 | 11 | 4 | 38 | |
| GSE60625 | PPT2 | 9374 | 0 | 1 | 10 | |
| GSE74703 | PPT2 | 9374 | 5 | 0 | 31 | |
| GSE74704 | PPT2 | 9374 | 2 | 0 | 18 | |
| TCGA | PPT2 | 9374 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of PPT2:
Generating mutation plots.
Highly correlated genes for PPT2:
Showing top 20/34 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPT2 | FKBPL | 0.766053 | 3 | 0 | 3 |
| PPT2 | KLHL18 | 0.751021 | 3 | 0 | 3 |
| PPT2 | KIAA0556 | 0.724367 | 3 | 0 | 3 |
| PPT2 | RHOG | 0.71351 | 3 | 0 | 3 |
| PPT2 | NOSIP | 0.711799 | 3 | 0 | 3 |
| PPT2 | GMPPB | 0.705338 | 3 | 0 | 3 |
| PPT2 | EIF2B4 | 0.701262 | 3 | 0 | 3 |
| PPT2 | APEH | 0.695467 | 3 | 0 | 3 |
| PPT2 | PRADC1 | 0.692116 | 3 | 0 | 3 |
| PPT2 | RABGGTA | 0.690354 | 3 | 0 | 3 |
| PPT2 | ATP6V1E1 | 0.68012 | 3 | 0 | 3 |
| PPT2 | FBXW9 | 0.678647 | 3 | 0 | 3 |
| PPT2 | EXOC2 | 0.677492 | 3 | 0 | 3 |
| PPT2 | ITCH | 0.676539 | 3 | 0 | 3 |
| PPT2 | RNF185 | 0.665614 | 3 | 0 | 3 |
| PPT2 | ZFYVE1 | 0.661968 | 3 | 0 | 3 |
| PPT2 | RAB14 | 0.659248 | 3 | 0 | 3 |
| PPT2 | TMEM120A | 0.656719 | 3 | 0 | 3 |
| PPT2 | SBF2 | 0.650258 | 3 | 0 | 3 |
| PPT2 | PTRHD1 | 0.649608 | 3 | 0 | 3 |
For details and further investigation, click here
