| Full name: ribonuclease P/MRP subunit p40 | Alias Symbol: bA428J1.3 | ||
| Type: protein-coding gene | Cytoband: 6p25.1 | ||
| Entrez ID: 10799 | HGNC ID: HGNC:20992 | Ensembl Gene: ENSG00000124787 | OMIM ID: 606117 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RPP40:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPP40 | 10799 | 213427_at | 0.8762 | 0.1893 | |
| GSE20347 | RPP40 | 10799 | 213427_at | 0.1698 | 0.4363 | |
| GSE23400 | RPP40 | 10799 | 213427_at | 0.5371 | 0.0000 | |
| GSE26886 | RPP40 | 10799 | 213427_at | -0.1044 | 0.7073 | |
| GSE29001 | RPP40 | 10799 | 213427_at | 0.3813 | 0.1887 | |
| GSE38129 | RPP40 | 10799 | 213427_at | 0.4690 | 0.0235 | |
| GSE45670 | RPP40 | 10799 | 213427_at | 0.3852 | 0.0126 | |
| GSE53622 | RPP40 | 10799 | 96256 | 0.3690 | 0.0000 | |
| GSE53624 | RPP40 | 10799 | 96256 | 0.3791 | 0.0000 | |
| GSE63941 | RPP40 | 10799 | 213427_at | -0.0572 | 0.9303 | |
| GSE77861 | RPP40 | 10799 | 213427_at | -0.1197 | 0.8182 | |
| GSE97050 | RPP40 | 10799 | A_23_P111297 | 0.2147 | 0.4531 | |
| SRP007169 | RPP40 | 10799 | RNAseq | 0.0806 | 0.8449 | |
| SRP008496 | RPP40 | 10799 | RNAseq | 0.0271 | 0.9236 | |
| SRP064894 | RPP40 | 10799 | RNAseq | 0.6087 | 0.0503 | |
| SRP133303 | RPP40 | 10799 | RNAseq | 0.1031 | 0.6359 | |
| SRP159526 | RPP40 | 10799 | RNAseq | 0.1453 | 0.6951 | |
| SRP193095 | RPP40 | 10799 | RNAseq | -0.1989 | 0.3766 | |
| SRP219564 | RPP40 | 10799 | RNAseq | 0.2836 | 0.6292 | |
| TCGA | RPP40 | 10799 | RNAseq | 0.5882 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RPP40 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPP40:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPP40 | 10799 | 3 | 6 | 21 | |
| GSE20123 | RPP40 | 10799 | 3 | 6 | 21 | |
| GSE43470 | RPP40 | 10799 | 8 | 2 | 33 | |
| GSE46452 | RPP40 | 10799 | 1 | 10 | 48 | |
| GSE47630 | RPP40 | 10799 | 7 | 8 | 25 | |
| GSE54993 | RPP40 | 10799 | 1 | 1 | 68 | |
| GSE54994 | RPP40 | 10799 | 10 | 3 | 40 | |
| GSE60625 | RPP40 | 10799 | 0 | 1 | 10 | |
| GSE74703 | RPP40 | 10799 | 7 | 2 | 27 | |
| GSE74704 | RPP40 | 10799 | 2 | 2 | 16 | |
| TCGA | RPP40 | 10799 | 14 | 29 | 53 |
Total number of gains: 56; Total number of losses: 70; Total Number of normals: 362.
Somatic mutations of RPP40:
Generating mutation plots.
Highly correlated genes for RPP40:
Showing top 20/915 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPP40 | DUSP23 | 0.799136 | 3 | 0 | 3 |
| RPP40 | ZNF700 | 0.790708 | 3 | 0 | 3 |
| RPP40 | CEP350 | 0.784037 | 3 | 0 | 3 |
| RPP40 | MDM2 | 0.781304 | 3 | 0 | 3 |
| RPP40 | ZNF207 | 0.770666 | 3 | 0 | 3 |
| RPP40 | ZNF765 | 0.770654 | 3 | 0 | 3 |
| RPP40 | MGST1 | 0.762811 | 3 | 0 | 3 |
| RPP40 | EIF3C | 0.762208 | 3 | 0 | 3 |
| RPP40 | TP53RK | 0.758982 | 3 | 0 | 3 |
| RPP40 | PPP4R2 | 0.745908 | 3 | 0 | 3 |
| RPP40 | ZSCAN12 | 0.738117 | 3 | 0 | 3 |
| RPP40 | ZNRD1 | 0.737717 | 4 | 0 | 3 |
| RPP40 | ELOF1 | 0.736677 | 3 | 0 | 3 |
| RPP40 | TYW5 | 0.728237 | 3 | 0 | 3 |
| RPP40 | STX6 | 0.724291 | 4 | 0 | 3 |
| RPP40 | RBBP6 | 0.723989 | 3 | 0 | 3 |
| RPP40 | TNFAIP8 | 0.715375 | 3 | 0 | 3 |
| RPP40 | HEATR5A | 0.71129 | 3 | 0 | 3 |
| RPP40 | EXOC6B | 0.710466 | 3 | 0 | 3 |
| RPP40 | HGS | 0.705674 | 4 | 0 | 3 |
For details and further investigation, click here
