| Full name: 5-hydroxytryptamine receptor 7 | Alias Symbol: 5-HT7 | ||
| Type: protein-coding gene | Cytoband: 10q23.31 | ||
| Entrez ID: 3363 | HGNC ID: HGNC:5302 | Ensembl Gene: ENSG00000148680 | OMIM ID: 182137 |
| Drug and gene relationship at DGIdb | |||
HTR7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04020 | Calcium signaling pathway | |
| hsa04726 | Serotonergic synapse |
Expression of HTR7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HTR7 | 3363 | 207927_at | 0.0856 | 0.7531 | |
| GSE20347 | HTR7 | 3363 | 207927_at | -0.0179 | 0.7694 | |
| GSE23400 | HTR7 | 3363 | 207927_at | -0.0630 | 0.0585 | |
| GSE26886 | HTR7 | 3363 | 207927_at | 0.1152 | 0.3514 | |
| GSE29001 | HTR7 | 3363 | 207927_at | 0.1362 | 0.3877 | |
| GSE38129 | HTR7 | 3363 | 207927_at | 0.0204 | 0.7388 | |
| GSE45670 | HTR7 | 3363 | 207927_at | 0.0327 | 0.6813 | |
| GSE53622 | HTR7 | 3363 | 108787 | 0.7028 | 0.0000 | |
| GSE53624 | HTR7 | 3363 | 108787 | 0.9572 | 0.0000 | |
| GSE63941 | HTR7 | 3363 | 207927_at | -0.0284 | 0.9014 | |
| GSE77861 | HTR7 | 3363 | 207927_at | -0.0851 | 0.5217 | |
| GSE97050 | HTR7 | 3363 | A_23_P500381 | 0.2565 | 0.3789 | |
| SRP133303 | HTR7 | 3363 | RNAseq | 1.0553 | 0.0056 | |
| SRP159526 | HTR7 | 3363 | RNAseq | 0.4619 | 0.5507 | |
| SRP193095 | HTR7 | 3363 | RNAseq | 1.5237 | 0.0000 | |
| TCGA | HTR7 | 3363 | RNAseq | 0.9000 | 0.0067 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by HTR7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HTR7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HTR7 | 3363 | 1 | 7 | 22 | |
| GSE20123 | HTR7 | 3363 | 1 | 6 | 23 | |
| GSE43470 | HTR7 | 3363 | 0 | 8 | 35 | |
| GSE46452 | HTR7 | 3363 | 0 | 11 | 48 | |
| GSE47630 | HTR7 | 3363 | 2 | 14 | 24 | |
| GSE54993 | HTR7 | 3363 | 7 | 0 | 63 | |
| GSE54994 | HTR7 | 3363 | 1 | 11 | 41 | |
| GSE60625 | HTR7 | 3363 | 0 | 0 | 11 | |
| GSE74703 | HTR7 | 3363 | 0 | 6 | 30 | |
| GSE74704 | HTR7 | 3363 | 0 | 4 | 16 | |
| TCGA | HTR7 | 3363 | 7 | 27 | 62 |
Total number of gains: 19; Total number of losses: 94; Total Number of normals: 375.
Somatic mutations of HTR7:
Generating mutation plots.
Highly correlated genes for HTR7:
Showing top 20/356 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HTR7 | JKAMP | 0.7273 | 3 | 0 | 3 |
| HTR7 | GTPBP10 | 0.694171 | 4 | 0 | 3 |
| HTR7 | MEX3B | 0.66753 | 4 | 0 | 4 |
| HTR7 | MRPL50 | 0.665085 | 3 | 0 | 3 |
| HTR7 | LRRD1 | 0.6618 | 3 | 0 | 3 |
| HTR7 | CDH24 | 0.658966 | 3 | 0 | 3 |
| HTR7 | TMEM41A | 0.658868 | 3 | 0 | 3 |
| HTR7 | POLN | 0.658706 | 3 | 0 | 3 |
| HTR7 | PSME1 | 0.658528 | 4 | 0 | 3 |
| HTR7 | FAM89A | 0.657515 | 3 | 0 | 3 |
| HTR7 | GSTA3 | 0.656918 | 3 | 0 | 3 |
| HTR7 | RHBDF2 | 0.652541 | 3 | 0 | 3 |
| HTR7 | KLHL8 | 0.651116 | 3 | 0 | 3 |
| HTR7 | PDCD2L | 0.649717 | 3 | 0 | 3 |
| HTR7 | FAM71F2 | 0.648782 | 3 | 0 | 3 |
| HTR7 | TBC1D22A | 0.644871 | 4 | 0 | 3 |
| HTR7 | TFRC | 0.643695 | 3 | 0 | 3 |
| HTR7 | ZNF207 | 0.641425 | 3 | 0 | 3 |
| HTR7 | DNAH11 | 0.640329 | 3 | 0 | 3 |
| HTR7 | UBE2O | 0.636492 | 4 | 0 | 3 |
For details and further investigation, click here
