| Full name: malate dehydrogenase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p15 | ||
| Entrez ID: 4190 | HGNC ID: HGNC:6970 | Ensembl Gene: ENSG00000014641 | OMIM ID: 154200 |
| Drug and gene relationship at DGIdb | |||
Expression of MDH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MDH1 | 4190 | 200978_at | 0.1802 | 0.6391 | |
| GSE20347 | MDH1 | 4190 | 200978_at | 0.1861 | 0.2424 | |
| GSE23400 | MDH1 | 4190 | 200978_at | 0.1554 | 0.0359 | |
| GSE26886 | MDH1 | 4190 | 200978_at | -0.2677 | 0.2453 | |
| GSE29001 | MDH1 | 4190 | 200978_at | -0.1105 | 0.7517 | |
| GSE38129 | MDH1 | 4190 | 200978_at | 0.0832 | 0.5417 | |
| GSE45670 | MDH1 | 4190 | 200978_at | 0.0593 | 0.6815 | |
| GSE53622 | MDH1 | 4190 | 60082 | -0.3774 | 0.0000 | |
| GSE53624 | MDH1 | 4190 | 60082 | -0.0415 | 0.3514 | |
| GSE63941 | MDH1 | 4190 | 200978_at | 0.8121 | 0.0031 | |
| GSE77861 | MDH1 | 4190 | 200978_at | 0.0863 | 0.8130 | |
| GSE97050 | MDH1 | 4190 | A_23_P101950 | -0.4422 | 0.2486 | |
| SRP007169 | MDH1 | 4190 | RNAseq | -0.0360 | 0.9200 | |
| SRP008496 | MDH1 | 4190 | RNAseq | -0.1626 | 0.4657 | |
| SRP064894 | MDH1 | 4190 | RNAseq | 0.1443 | 0.2680 | |
| SRP133303 | MDH1 | 4190 | RNAseq | 0.1889 | 0.1580 | |
| SRP159526 | MDH1 | 4190 | RNAseq | 0.2726 | 0.2316 | |
| SRP193095 | MDH1 | 4190 | RNAseq | -0.3311 | 0.0221 | |
| SRP219564 | MDH1 | 4190 | RNAseq | -0.4881 | 0.2811 | |
| TCGA | MDH1 | 4190 | RNAseq | -0.1578 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MDH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MDH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MDH1 | 4190 | 12 | 0 | 18 | |
| GSE20123 | MDH1 | 4190 | 12 | 0 | 18 | |
| GSE43470 | MDH1 | 4190 | 7 | 0 | 36 | |
| GSE46452 | MDH1 | 4190 | 2 | 3 | 54 | |
| GSE47630 | MDH1 | 4190 | 8 | 0 | 32 | |
| GSE54993 | MDH1 | 4190 | 0 | 7 | 63 | |
| GSE54994 | MDH1 | 4190 | 12 | 0 | 41 | |
| GSE60625 | MDH1 | 4190 | 0 | 3 | 8 | |
| GSE74703 | MDH1 | 4190 | 7 | 0 | 29 | |
| GSE74704 | MDH1 | 4190 | 10 | 0 | 10 | |
| TCGA | MDH1 | 4190 | 35 | 3 | 58 |
Total number of gains: 105; Total number of losses: 16; Total Number of normals: 367.
Somatic mutations of MDH1:
Generating mutation plots.
Highly correlated genes for MDH1:
Showing top 20/490 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MDH1 | MTCH2 | 0.745545 | 3 | 0 | 3 |
| MDH1 | GPS2 | 0.715312 | 3 | 0 | 3 |
| MDH1 | KLHL13 | 0.699399 | 3 | 0 | 3 |
| MDH1 | DPY30 | 0.695066 | 7 | 0 | 5 |
| MDH1 | ARFGEF2 | 0.690851 | 3 | 0 | 3 |
| MDH1 | CD164 | 0.6634 | 4 | 0 | 3 |
| MDH1 | SOCS5 | 0.663325 | 7 | 0 | 7 |
| MDH1 | IDH3A | 0.661862 | 3 | 0 | 3 |
| MDH1 | B4GALNT4 | 0.661772 | 3 | 0 | 3 |
| MDH1 | HMGB2 | 0.660132 | 3 | 0 | 3 |
| MDH1 | TYW3 | 0.655636 | 3 | 0 | 3 |
| MDH1 | IMMT | 0.654672 | 10 | 0 | 10 |
| MDH1 | WDR61 | 0.6542 | 5 | 0 | 4 |
| MDH1 | SF3B6 | 0.654007 | 4 | 0 | 3 |
| MDH1 | COPS2 | 0.653472 | 5 | 0 | 4 |
| MDH1 | NGRN | 0.652276 | 5 | 0 | 4 |
| MDH1 | ARHGEF39 | 0.649761 | 3 | 0 | 3 |
| MDH1 | CCNG1 | 0.649719 | 3 | 0 | 3 |
| MDH1 | FYTTD1 | 0.645929 | 3 | 0 | 3 |
| MDH1 | RNF139 | 0.64334 | 3 | 0 | 3 |
For details and further investigation, click here
