| Full name: ER membrane protein complex subunit 6 | Alias Symbol: MGC2963|RAB5IFL | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 83460 | HGNC ID: HGNC:28430 | Ensembl Gene: ENSG00000127774 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EMC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EMC6 | 83460 | 221255_s_at | 0.4639 | 0.1054 | |
| GSE20347 | EMC6 | 83460 | 221255_s_at | 0.2639 | 0.0513 | |
| GSE23400 | EMC6 | 83460 | 221255_s_at | 0.3241 | 0.0000 | |
| GSE26886 | EMC6 | 83460 | 221255_s_at | 0.2080 | 0.2611 | |
| GSE29001 | EMC6 | 83460 | 221255_s_at | 0.1512 | 0.6067 | |
| GSE38129 | EMC6 | 83460 | 221255_s_at | 0.3440 | 0.0007 | |
| GSE45670 | EMC6 | 83460 | 221255_s_at | 0.3780 | 0.0042 | |
| GSE63941 | EMC6 | 83460 | 221255_s_at | 0.2733 | 0.2484 | |
| GSE77861 | EMC6 | 83460 | 221255_s_at | 0.5254 | 0.0134 | |
| SRP007169 | EMC6 | 83460 | RNAseq | -0.2050 | 0.6522 | |
| SRP008496 | EMC6 | 83460 | RNAseq | -0.2616 | 0.3237 | |
| SRP064894 | EMC6 | 83460 | RNAseq | 0.3949 | 0.2141 | |
| SRP133303 | EMC6 | 83460 | RNAseq | 0.1967 | 0.2237 | |
| SRP159526 | EMC6 | 83460 | RNAseq | 0.2312 | 0.2036 | |
| SRP193095 | EMC6 | 83460 | RNAseq | 0.0202 | 0.9076 | |
| SRP219564 | EMC6 | 83460 | RNAseq | 0.1407 | 0.6980 |
Upregulated datasets: 0; Downregulated datasets: 0.
Copy number change of EMC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EMC6 | 83460 | 5 | 3 | 22 | |
| GSE20123 | EMC6 | 83460 | 5 | 4 | 21 | |
| GSE43470 | EMC6 | 83460 | 1 | 6 | 36 | |
| GSE46452 | EMC6 | 83460 | 34 | 1 | 24 | |
| GSE47630 | EMC6 | 83460 | 7 | 1 | 32 | |
| GSE54993 | EMC6 | 83460 | 4 | 3 | 63 | |
| GSE54994 | EMC6 | 83460 | 5 | 9 | 39 | |
| GSE60625 | EMC6 | 83460 | 4 | 0 | 7 | |
| GSE74703 | EMC6 | 83460 | 1 | 3 | 32 | |
| GSE74704 | EMC6 | 83460 | 3 | 2 | 15 | |
| TCGA | EMC6 | 83460 | 17 | 21 | 58 |
Total number of gains: 86; Total number of losses: 53; Total Number of normals: 349.
Somatic mutations of EMC6:
Generating mutation plots.
Highly correlated genes for EMC6:
Showing top 20/614 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EMC6 | CPNE8 | 0.741099 | 3 | 0 | 3 |
| EMC6 | NOP58 | 0.718643 | 3 | 0 | 3 |
| EMC6 | RAB3IP | 0.711831 | 3 | 0 | 3 |
| EMC6 | ACVR1C | 0.706591 | 3 | 0 | 3 |
| EMC6 | PSMB6 | 0.702442 | 8 | 0 | 8 |
| EMC6 | WDR81 | 0.70166 | 3 | 0 | 3 |
| EMC6 | NUDCD1 | 0.693491 | 3 | 0 | 3 |
| EMC6 | TMEM138 | 0.688002 | 3 | 0 | 3 |
| EMC6 | DCAF13 | 0.684795 | 3 | 0 | 3 |
| EMC6 | DNAJB11 | 0.682497 | 3 | 0 | 3 |
| EMC6 | DHX33 | 0.681231 | 4 | 0 | 3 |
| EMC6 | NUF2 | 0.672518 | 3 | 0 | 3 |
| EMC6 | SLC25A11 | 0.672241 | 7 | 0 | 7 |
| EMC6 | C5orf22 | 0.670117 | 3 | 0 | 3 |
| EMC6 | NEB | 0.668631 | 3 | 0 | 3 |
| EMC6 | DHRS13 | 0.665889 | 3 | 0 | 3 |
| EMC6 | C1orf131 | 0.664934 | 3 | 0 | 3 |
| EMC6 | YWHAG | 0.664612 | 3 | 0 | 3 |
| EMC6 | ZNF593 | 0.658274 | 6 | 0 | 5 |
| EMC6 | MTFR2 | 0.655274 | 3 | 0 | 3 |
For details and further investigation, click here
