| Full name: activin A receptor type 1C | Alias Symbol: ALK7|ACVRLK7 | ||
| Type: protein-coding gene | Cytoband: 2q24.1 | ||
| Entrez ID: 130399 | HGNC ID: HGNC:18123 | Ensembl Gene: ENSG00000123612 | OMIM ID: 608981 |
| Drug and gene relationship at DGIdb | |||
ACVR1C involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of ACVR1C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACVR1C | 130399 | 1552519_at | 2.2061 | 0.0194 | |
| GSE26886 | ACVR1C | 130399 | 1552519_at | 1.5458 | 0.0000 | |
| GSE45670 | ACVR1C | 130399 | 1552519_at | 1.9258 | 0.0000 | |
| GSE53622 | ACVR1C | 130399 | 89059 | 0.3182 | 0.0187 | |
| GSE53624 | ACVR1C | 130399 | 89059 | -0.1184 | 0.5408 | |
| GSE63941 | ACVR1C | 130399 | 1552519_at | 2.0701 | 0.1219 | |
| GSE77861 | ACVR1C | 130399 | 1552519_at | 1.1679 | 0.0127 | |
| GSE97050 | ACVR1C | 130399 | A_23_P397455 | -0.1820 | 0.5089 | |
| SRP007169 | ACVR1C | 130399 | RNAseq | 2.5185 | 0.0026 | |
| SRP008496 | ACVR1C | 130399 | RNAseq | 4.4537 | 0.0000 | |
| SRP133303 | ACVR1C | 130399 | RNAseq | 2.3147 | 0.0000 | |
| SRP159526 | ACVR1C | 130399 | RNAseq | 1.9704 | 0.0026 | |
| SRP193095 | ACVR1C | 130399 | RNAseq | 1.7384 | 0.0000 | |
| SRP219564 | ACVR1C | 130399 | RNAseq | 2.9723 | 0.0001 | |
| TCGA | ACVR1C | 130399 | RNAseq | 0.3775 | 0.0636 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by ACVR1C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACVR1C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACVR1C | 130399 | 4 | 1 | 25 | |
| GSE20123 | ACVR1C | 130399 | 4 | 1 | 25 | |
| GSE43470 | ACVR1C | 130399 | 4 | 1 | 38 | |
| GSE46452 | ACVR1C | 130399 | 1 | 4 | 54 | |
| GSE47630 | ACVR1C | 130399 | 5 | 3 | 32 | |
| GSE54993 | ACVR1C | 130399 | 0 | 4 | 66 | |
| GSE54994 | ACVR1C | 130399 | 11 | 2 | 40 | |
| GSE60625 | ACVR1C | 130399 | 0 | 3 | 8 | |
| GSE74703 | ACVR1C | 130399 | 3 | 1 | 32 | |
| GSE74704 | ACVR1C | 130399 | 3 | 0 | 17 | |
| TCGA | ACVR1C | 130399 | 22 | 10 | 64 |
Total number of gains: 57; Total number of losses: 30; Total Number of normals: 401.
Somatic mutations of ACVR1C:
Generating mutation plots.
Highly correlated genes for ACVR1C:
Showing top 20/1024 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACVR1C | COLGALT1 | 0.779995 | 4 | 0 | 4 |
| ACVR1C | EXT1 | 0.777903 | 4 | 0 | 4 |
| ACVR1C | ARHGEF19 | 0.767551 | 3 | 0 | 3 |
| ACVR1C | HOXC10 | 0.763293 | 4 | 0 | 3 |
| ACVR1C | MTERF3 | 0.761207 | 4 | 0 | 4 |
| ACVR1C | PTK7 | 0.753919 | 4 | 0 | 4 |
| ACVR1C | FZD6 | 0.749156 | 4 | 0 | 4 |
| ACVR1C | AGRN | 0.742839 | 5 | 0 | 5 |
| ACVR1C | DDX55 | 0.740194 | 5 | 0 | 5 |
| ACVR1C | HS6ST1 | 0.738912 | 3 | 0 | 3 |
| ACVR1C | SLC39A10 | 0.738648 | 4 | 0 | 4 |
| ACVR1C | PLEKHG4B | 0.738466 | 3 | 0 | 3 |
| ACVR1C | STK3 | 0.738296 | 5 | 0 | 5 |
| ACVR1C | THUMPD2 | 0.737396 | 3 | 0 | 3 |
| ACVR1C | FMNL2 | 0.735628 | 4 | 0 | 4 |
| ACVR1C | PLXNA1 | 0.734982 | 5 | 0 | 5 |
| ACVR1C | WDR75 | 0.734575 | 5 | 0 | 5 |
| ACVR1C | ZBTB41 | 0.732317 | 4 | 0 | 4 |
| ACVR1C | PSMB4 | 0.731877 | 5 | 0 | 5 |
| ACVR1C | HOXA10 | 0.730196 | 5 | 0 | 5 |
For details and further investigation, click here
