| Full name: NUF2 component of NDC80 kinetochore complex | Alias Symbol: NUF2R|CT106 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 83540 | HGNC ID: HGNC:14621 | Ensembl Gene: ENSG00000143228 | OMIM ID: 611772 |
| Drug and gene relationship at DGIdb | |||
Expression of NUF2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NUF2 | 83540 | 223381_at | 1.7217 | 0.0330 | |
| GSE26886 | NUF2 | 83540 | 223381_at | 1.4960 | 0.0006 | |
| GSE45670 | NUF2 | 83540 | 223381_at | 1.9180 | 0.0000 | |
| GSE53622 | NUF2 | 83540 | 28969 | 1.5234 | 0.0000 | |
| GSE53624 | NUF2 | 83540 | 28969 | 1.5923 | 0.0000 | |
| GSE63941 | NUF2 | 83540 | 223381_at | 3.5455 | 0.0000 | |
| GSE77861 | NUF2 | 83540 | 223381_at | 1.6844 | 0.0015 | |
| GSE97050 | NUF2 | 83540 | A_23_P74349 | 0.8229 | 0.3023 | |
| SRP007169 | NUF2 | 83540 | RNAseq | 2.5239 | 0.0002 | |
| SRP064894 | NUF2 | 83540 | RNAseq | 1.4976 | 0.0000 | |
| SRP133303 | NUF2 | 83540 | RNAseq | 1.8412 | 0.0000 | |
| SRP159526 | NUF2 | 83540 | RNAseq | 1.5630 | 0.0000 | |
| SRP193095 | NUF2 | 83540 | RNAseq | 1.0845 | 0.0000 | |
| SRP219564 | NUF2 | 83540 | RNAseq | 1.6239 | 0.0432 | |
| TCGA | NUF2 | 83540 | RNAseq | 1.6367 | 0.0000 |
Upregulated datasets: 14; Downregulated datasets: 0.
Survival by NUF2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NUF2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NUF2 | 83540 | 10 | 0 | 20 | |
| GSE20123 | NUF2 | 83540 | 10 | 0 | 20 | |
| GSE43470 | NUF2 | 83540 | 7 | 2 | 34 | |
| GSE46452 | NUF2 | 83540 | 2 | 1 | 56 | |
| GSE47630 | NUF2 | 83540 | 14 | 0 | 26 | |
| GSE54993 | NUF2 | 83540 | 0 | 5 | 65 | |
| GSE54994 | NUF2 | 83540 | 16 | 0 | 37 | |
| GSE60625 | NUF2 | 83540 | 0 | 0 | 11 | |
| GSE74703 | NUF2 | 83540 | 7 | 2 | 27 | |
| GSE74704 | NUF2 | 83540 | 4 | 0 | 16 | |
| TCGA | NUF2 | 83540 | 43 | 3 | 50 |
Total number of gains: 113; Total number of losses: 13; Total Number of normals: 362.
Somatic mutations of NUF2:
Generating mutation plots.
Highly correlated genes for NUF2:
Showing top 20/2010 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NUF2 | ASPM | 0.890357 | 9 | 0 | 9 |
| NUF2 | NEK2 | 0.880422 | 9 | 0 | 9 |
| NUF2 | CENPF | 0.868385 | 9 | 0 | 9 |
| NUF2 | TOP2A | 0.858565 | 9 | 0 | 9 |
| NUF2 | KIF14 | 0.857814 | 9 | 0 | 9 |
| NUF2 | BUB1 | 0.852456 | 9 | 0 | 9 |
| NUF2 | SPC25 | 0.847386 | 7 | 0 | 7 |
| NUF2 | UBE2C | 0.837515 | 9 | 0 | 8 |
| NUF2 | ATAD2 | 0.836512 | 9 | 0 | 8 |
| NUF2 | SPAG5 | 0.835316 | 9 | 0 | 8 |
| NUF2 | CCNB2 | 0.835115 | 8 | 0 | 8 |
| NUF2 | EXO1 | 0.834207 | 8 | 0 | 8 |
| NUF2 | CDC20 | 0.833252 | 7 | 0 | 7 |
| NUF2 | TPX2 | 0.832402 | 9 | 0 | 8 |
| NUF2 | DTL | 0.831127 | 9 | 0 | 9 |
| NUF2 | NUSAP1 | 0.829591 | 9 | 0 | 9 |
| NUF2 | GINS1 | 0.829483 | 8 | 0 | 8 |
| NUF2 | KIF20A | 0.829454 | 9 | 0 | 8 |
| NUF2 | MTFR2 | 0.82836 | 7 | 0 | 7 |
| NUF2 | UBE2T | 0.827992 | 9 | 0 | 9 |
For details and further investigation, click here
