| Full name: ectonucleotide pyrophosphatase/phosphodiesterase 3 | Alias Symbol: PD-IBETA|gp130RB13-6|B10|CD203c | ||
| Type: protein-coding gene | Cytoband: 6q23.2 | ||
| Entrez ID: 5169 | HGNC ID: HGNC:3358 | Ensembl Gene: ENSG00000154269 | OMIM ID: 602182 |
| Drug and gene relationship at DGIdb | |||
Expression of ENPP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ENPP3 | 5169 | 222938_x_at | -0.0243 | 0.9487 | |
| GSE26886 | ENPP3 | 5169 | 222938_x_at | -0.1540 | 0.1829 | |
| GSE45670 | ENPP3 | 5169 | 222938_x_at | -0.0794 | 0.5287 | |
| GSE53622 | ENPP3 | 5169 | 1838 | -0.6372 | 0.0000 | |
| GSE53624 | ENPP3 | 5169 | 1838 | -0.3735 | 0.0075 | |
| GSE63941 | ENPP3 | 5169 | 222938_x_at | 0.1480 | 0.4628 | |
| GSE77861 | ENPP3 | 5169 | 222938_x_at | -0.1776 | 0.1741 | |
| SRP133303 | ENPP3 | 5169 | RNAseq | -2.4080 | 0.0000 | |
| TCGA | ENPP3 | 5169 | RNAseq | -2.6262 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ENPP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ENPP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ENPP3 | 5169 | 2 | 5 | 23 | |
| GSE20123 | ENPP3 | 5169 | 2 | 4 | 24 | |
| GSE43470 | ENPP3 | 5169 | 5 | 0 | 38 | |
| GSE46452 | ENPP3 | 5169 | 2 | 11 | 46 | |
| GSE47630 | ENPP3 | 5169 | 9 | 4 | 27 | |
| GSE54993 | ENPP3 | 5169 | 3 | 2 | 65 | |
| GSE54994 | ENPP3 | 5169 | 9 | 7 | 37 | |
| GSE60625 | ENPP3 | 5169 | 0 | 1 | 10 | |
| GSE74703 | ENPP3 | 5169 | 4 | 0 | 32 | |
| GSE74704 | ENPP3 | 5169 | 1 | 1 | 18 | |
| TCGA | ENPP3 | 5169 | 11 | 19 | 66 |
Total number of gains: 48; Total number of losses: 54; Total Number of normals: 386.
Somatic mutations of ENPP3:
Generating mutation plots.
Highly correlated genes for ENPP3:
Showing top 20/111 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ENPP3 | LINC01111 | 0.739048 | 3 | 0 | 3 |
| ENPP3 | CD5L | 0.708763 | 3 | 0 | 3 |
| ENPP3 | PRAMEF12 | 0.708584 | 3 | 0 | 3 |
| ENPP3 | CRLF2 | 0.700093 | 3 | 0 | 3 |
| ENPP3 | C2orf16 | 0.694955 | 3 | 0 | 3 |
| ENPP3 | SFMBT2 | 0.687427 | 3 | 0 | 3 |
| ENPP3 | ZCWPW1 | 0.672846 | 3 | 0 | 3 |
| ENPP3 | TTLL7-IT1 | 0.655182 | 3 | 0 | 3 |
| ENPP3 | CNR2 | 0.651914 | 4 | 0 | 3 |
| ENPP3 | DCST1 | 0.645975 | 4 | 0 | 4 |
| ENPP3 | CSRP3 | 0.642342 | 3 | 0 | 3 |
| ENPP3 | NLRP8 | 0.63305 | 4 | 0 | 3 |
| ENPP3 | NHLRC4 | 0.631288 | 4 | 0 | 3 |
| ENPP3 | FGA | 0.630412 | 3 | 0 | 3 |
| ENPP3 | GPR137 | 0.627387 | 3 | 0 | 3 |
| ENPP3 | LINC00689 | 0.618918 | 3 | 0 | 3 |
| ENPP3 | RNASE3 | 0.617676 | 3 | 0 | 3 |
| ENPP3 | YBX2 | 0.617629 | 4 | 0 | 3 |
| ENPP3 | SNX32 | 0.610299 | 3 | 0 | 3 |
| ENPP3 | HAND1 | 0.605656 | 3 | 0 | 3 |
For details and further investigation, click here
