| Full name: EPH receptor A8 | Alias Symbol: Hek3 | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 2046 | HGNC ID: HGNC:3391 | Ensembl Gene: ENSG00000070886 | OMIM ID: 176945 |
| Drug and gene relationship at DGIdb | |||
EPHA8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of EPHA8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPHA8 | 2046 | 231796_at | -0.0589 | 0.8473 | |
| GSE26886 | EPHA8 | 2046 | 1554069_at | -0.0482 | 0.6780 | |
| GSE45670 | EPHA8 | 2046 | 231796_at | 0.0034 | 0.9804 | |
| GSE53622 | EPHA8 | 2046 | 29215 | 0.2097 | 0.0091 | |
| GSE53624 | EPHA8 | 2046 | 29215 | -0.1753 | 0.0728 | |
| GSE63941 | EPHA8 | 2046 | 231796_at | 0.0775 | 0.7018 | |
| GSE77861 | EPHA8 | 2046 | 231796_at | -0.1150 | 0.5218 | |
| GSE97050 | EPHA8 | 2046 | A_33_P3408852 | -0.1090 | 0.5920 | |
| TCGA | EPHA8 | 2046 | RNAseq | 2.8129 | 0.0024 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by EPHA8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPHA8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPHA8 | 2046 | 0 | 5 | 25 | |
| GSE20123 | EPHA8 | 2046 | 0 | 4 | 26 | |
| GSE43470 | EPHA8 | 2046 | 2 | 6 | 35 | |
| GSE46452 | EPHA8 | 2046 | 5 | 1 | 53 | |
| GSE47630 | EPHA8 | 2046 | 8 | 3 | 29 | |
| GSE54993 | EPHA8 | 2046 | 2 | 1 | 67 | |
| GSE54994 | EPHA8 | 2046 | 11 | 4 | 38 | |
| GSE60625 | EPHA8 | 2046 | 0 | 0 | 11 | |
| GSE74703 | EPHA8 | 2046 | 1 | 4 | 31 | |
| GSE74704 | EPHA8 | 2046 | 0 | 0 | 20 | |
| TCGA | EPHA8 | 2046 | 10 | 23 | 63 |
Total number of gains: 39; Total number of losses: 51; Total Number of normals: 398.
Somatic mutations of EPHA8:
Generating mutation plots.
Highly correlated genes for EPHA8:
Showing top 20/99 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPHA8 | PRAP1 | 0.643008 | 3 | 0 | 3 |
| EPHA8 | ADCY4 | 0.638676 | 3 | 0 | 3 |
| EPHA8 | SEMA6C | 0.633731 | 4 | 0 | 4 |
| EPHA8 | UCMA | 0.619835 | 4 | 0 | 4 |
| EPHA8 | ZNF280A | 0.607893 | 3 | 0 | 3 |
| EPHA8 | ANO7 | 0.601872 | 4 | 0 | 3 |
| EPHA8 | OSM | 0.597641 | 4 | 0 | 4 |
| EPHA8 | FAM135B | 0.596637 | 5 | 0 | 4 |
| EPHA8 | MPZ | 0.59583 | 4 | 0 | 3 |
| EPHA8 | TSGA10IP | 0.594048 | 3 | 0 | 3 |
| EPHA8 | GSX1 | 0.58868 | 5 | 0 | 3 |
| EPHA8 | MYOG | 0.585208 | 4 | 0 | 3 |
| EPHA8 | C1orf194 | 0.581945 | 5 | 0 | 3 |
| EPHA8 | PVALB | 0.578881 | 4 | 0 | 3 |
| EPHA8 | CASC6 | 0.574675 | 3 | 0 | 3 |
| EPHA8 | CACNG4 | 0.574619 | 5 | 0 | 3 |
| EPHA8 | LUZP4 | 0.574506 | 3 | 0 | 3 |
| EPHA8 | NEFH | 0.573878 | 4 | 0 | 3 |
| EPHA8 | SCGB2B2 | 0.572727 | 4 | 0 | 3 |
| EPHA8 | CASS4 | 0.572699 | 5 | 0 | 5 |
For details and further investigation, click here
