ADCY4

 

Full name: adenylate cyclase 4 Alias Symbol: AC4
Type: protein-coding gene Cytoband: 14q12
Entrez ID: 196883 HGNC ID: HGNC:235 Ensembl Gene: ENSG00000129467 OMIM ID: 600292
Drug and gene relationship at DGIdb

 

ADCY4 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04114Oocyte meiosis
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04742Taste transduction
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04912GnRH signaling pathway
hsa04913Ovarian steroidogenesis
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04976Bile secretion
hsa05032Morphine addiction
hsa05166HTLV-I infection

 

Expression of ADCY4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ADCY4 196883 230800_at -0.3546 0.3986
GSE26886 ADCY4 196883 230800_at -0.0477 0.7389
GSE45670 ADCY4 196883 230800_at -0.7415 0.0001
GSE53622 ADCY4 196883 37043 -0.3624 0.0000
GSE53624 ADCY4 196883 107949 -0.6468 0.0000
GSE63941 ADCY4 196883 230800_at 0.2451 0.1927
GSE77861 ADCY4 196883 230800_at -0.0510 0.8303
GSE97050 ADCY4 196883 A_33_P3337161 0.1352 0.5545
SRP007169 ADCY4 196883 RNAseq -0.0752 0.9103
SRP064894 ADCY4 196883 RNAseq 0.2483 0.4496
SRP133303 ADCY4 196883 RNAseq -1.2388 0.0000
SRP159526 ADCY4 196883 RNAseq -1.0150 0.0312
SRP193095 ADCY4 196883 RNAseq 0.5939 0.0047
SRP219564 ADCY4 196883 RNAseq -0.2217 0.6419
TCGA ADCY4 196883 RNAseq -0.6260 0.0000

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by ADCY4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ADCY4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ADCY4 196883 8 3 19
GSE20123 ADCY4 196883 8 3 19
GSE43470 ADCY4 196883 8 2 33
GSE46452 ADCY4 196883 16 2 41
GSE47630 ADCY4 196883 11 10 19
GSE54993 ADCY4 196883 3 11 56
GSE54994 ADCY4 196883 18 5 30
GSE60625 ADCY4 196883 0 2 9
GSE74703 ADCY4 196883 7 2 27
GSE74704 ADCY4 196883 3 2 15
TCGA ADCY4 196883 27 12 57

Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.  

 

Somatic mutations of ADCY4:

 

Generating mutation plots.

 

Highly correlated genes for ADCY4:

 

Showing top 20/119 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ADCY4SCAMP50.677478303
ADCY4EGFL70.657411404
ADCY4GIMAP60.656561303
ADCY4EPHA80.638676303
ADCY4SHANK30.634818504
ADCY4SLIT30.628437303
ADCY4LSMEM20.627423303
ADCY4MAP3K120.619157404
ADCY4GJA40.618724504
ADCY4AIF10.611663303
ADCY4DCAF80.606466303
ADCY4PLEK0.602632404
ADCY4CACNB20.602008403
ADCY4SOD30.599091604
ADCY4MAPK8IP30.598097403
ADCY4TDRD100.596966404
ADCY4AQP10.596262503
ADCY4SEMA3G0.594364604
ADCY4FHL50.593543403
ADCY4XKR40.59336403

For details and further investigation, click here