CDC25A

 

Full name: cell division cycle 25A Alias Symbol: 
Type: protein-coding gene Cytoband: 3p21.31
Entrez ID: 993 HGNC ID: HGNC:1725 Ensembl Gene: ENSG00000164045 OMIM ID: 116947
Drug and gene relationship at DGIdb
Screen Evidence:

 

CDC25A involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04914Progesterone-mediated oocyte maturation

 

Expression of CDC25A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CDC25A 993 204695_at 1.1026 0.0502
GSE20347 CDC25A 993 204695_at 0.5616 0.0003
GSE23400 CDC25A 993 204695_at 0.4328 0.0000
GSE26886 CDC25A 993 204695_at 0.0797 0.7773
GSE29001 CDC25A 993 204695_at 0.3194 0.1923
GSE38129 CDC25A 993 204695_at 0.8041 0.0000
GSE45670 CDC25A 993 204695_at 0.9536 0.0001
GSE53622 CDC25A 993 88480 0.7356 0.0001
GSE53624 CDC25A 993 88480 1.2972 0.0000
GSE63941 CDC25A 993 204695_at 1.5077 0.0001
GSE77861 CDC25A 993 204695_at 0.5077 0.0438
GSE97050 CDC25A 993 A_24_P397107 0.2731 0.2124
SRP007169 CDC25A 993 RNAseq 2.7279 0.0001
SRP064894 CDC25A 993 RNAseq 0.5324 0.0299
SRP133303 CDC25A 993 RNAseq 1.3275 0.0001
SRP159526 CDC25A 993 RNAseq 1.1079 0.0065
SRP193095 CDC25A 993 RNAseq 0.7443 0.0000
SRP219564 CDC25A 993 RNAseq 1.0967 0.1084
TCGA CDC25A 993 RNAseq 0.7367 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by CDC25A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CDC25A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CDC25A 993 0 18 12
GSE20123 CDC25A 993 0 19 11
GSE43470 CDC25A 993 0 19 24
GSE46452 CDC25A 993 2 17 40
GSE47630 CDC25A 993 1 24 15
GSE54993 CDC25A 993 6 2 62
GSE54994 CDC25A 993 0 36 17
GSE60625 CDC25A 993 5 0 6
GSE74703 CDC25A 993 0 15 21
GSE74704 CDC25A 993 0 12 8
TCGA CDC25A 993 0 77 19

Total number of gains: 14; Total number of losses: 239; Total Number of normals: 235.  

 

Somatic mutations of CDC25A:

 

Generating mutation plots.

 

Highly correlated genes for CDC25A:

 

Showing top 20/1687 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CDC25ADHX370.781928505
CDC25APTBP10.76436711011
CDC25ASLC39A30.762673303
CDC25AKTI120.760916303
CDC25AAP3D10.755474303
CDC25AUBQLN40.749685404
CDC25ACDT10.7450110010
CDC25ALRRC580.742798403
CDC25ACDC450.73978910010
CDC25AANKRD540.738405303
CDC25AEPN10.736942303
CDC25ADDX39A0.73497610010
CDC25AATRIP0.730867303
CDC25APTCD10.730827303
CDC25ATIMELESS0.7303712012
CDC25ATMEM540.724926303
CDC25APSMG30.723683606
CDC25AEFTUD20.722749807
CDC25ALIN90.722475707
CDC25ADDIAS0.722112606

For details and further investigation, click here