| Full name: DExH-box helicase 57 | Alias Symbol: DDX57 | ||
| Type: protein-coding gene | Cytoband: 2p22.1 | ||
| Entrez ID: 90957 | HGNC ID: HGNC:20086 | Ensembl Gene: ENSG00000163214 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of DHX57:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DHX57 | 90957 | 213420_at | 0.5248 | 0.0900 | |
| GSE20347 | DHX57 | 90957 | 213420_at | 0.4065 | 0.0164 | |
| GSE23400 | DHX57 | 90957 | 213420_at | 0.0195 | 0.5706 | |
| GSE26886 | DHX57 | 90957 | 213420_at | 0.3197 | 0.0765 | |
| GSE29001 | DHX57 | 90957 | 213420_at | 0.4613 | 0.0127 | |
| GSE38129 | DHX57 | 90957 | 213420_at | 0.3575 | 0.0023 | |
| GSE45670 | DHX57 | 90957 | 213420_at | 0.4046 | 0.0032 | |
| GSE53622 | DHX57 | 90957 | 8985 | 0.3726 | 0.0000 | |
| GSE53624 | DHX57 | 90957 | 101885 | 0.6815 | 0.0000 | |
| GSE63941 | DHX57 | 90957 | 213420_at | -0.3050 | 0.5307 | |
| GSE77861 | DHX57 | 90957 | 213420_at | 0.1380 | 0.4331 | |
| GSE97050 | DHX57 | 90957 | A_24_P120109 | 0.2477 | 0.4095 | |
| SRP007169 | DHX57 | 90957 | RNAseq | 1.7159 | 0.0000 | |
| SRP008496 | DHX57 | 90957 | RNAseq | 2.5454 | 0.0000 | |
| SRP064894 | DHX57 | 90957 | RNAseq | 0.4636 | 0.0001 | |
| SRP133303 | DHX57 | 90957 | RNAseq | 0.3881 | 0.0001 | |
| SRP159526 | DHX57 | 90957 | RNAseq | 1.1137 | 0.0000 | |
| SRP193095 | DHX57 | 90957 | RNAseq | 0.5674 | 0.0000 | |
| SRP219564 | DHX57 | 90957 | RNAseq | 0.2770 | 0.3787 | |
| TCGA | DHX57 | 90957 | RNAseq | 0.1177 | 0.0301 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DHX57 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DHX57:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DHX57 | 90957 | 11 | 1 | 18 | |
| GSE20123 | DHX57 | 90957 | 10 | 1 | 19 | |
| GSE43470 | DHX57 | 90957 | 3 | 0 | 40 | |
| GSE46452 | DHX57 | 90957 | 1 | 4 | 54 | |
| GSE47630 | DHX57 | 90957 | 7 | 0 | 33 | |
| GSE54993 | DHX57 | 90957 | 0 | 5 | 65 | |
| GSE54994 | DHX57 | 90957 | 10 | 0 | 43 | |
| GSE60625 | DHX57 | 90957 | 0 | 3 | 8 | |
| GSE74703 | DHX57 | 90957 | 3 | 0 | 33 | |
| GSE74704 | DHX57 | 90957 | 9 | 1 | 10 | |
| TCGA | DHX57 | 90957 | 35 | 2 | 59 |
Total number of gains: 89; Total number of losses: 17; Total Number of normals: 382.
Somatic mutations of DHX57:
Generating mutation plots.
Highly correlated genes for DHX57:
Showing top 20/1320 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DHX57 | RAD18 | 0.780443 | 3 | 0 | 3 |
| DHX57 | TWISTNB | 0.777523 | 3 | 0 | 3 |
| DHX57 | NF1 | 0.77163 | 3 | 0 | 3 |
| DHX57 | SPNS1 | 0.762173 | 3 | 0 | 3 |
| DHX57 | TOMM22 | 0.761153 | 3 | 0 | 3 |
| DHX57 | DNAJC19 | 0.760984 | 3 | 0 | 3 |
| DHX57 | AEBP2 | 0.754956 | 3 | 0 | 3 |
| DHX57 | TBRG4 | 0.752819 | 3 | 0 | 3 |
| DHX57 | LRRC58 | 0.750365 | 3 | 0 | 3 |
| DHX57 | DDX20 | 0.749869 | 4 | 0 | 3 |
| DHX57 | CHD8 | 0.74823 | 3 | 0 | 3 |
| DHX57 | XRCC6 | 0.742861 | 4 | 0 | 4 |
| DHX57 | MRPL38 | 0.737789 | 3 | 0 | 3 |
| DHX57 | PIGU | 0.733309 | 3 | 0 | 3 |
| DHX57 | MAP4K4 | 0.73221 | 3 | 0 | 3 |
| DHX57 | EPS8 | 0.730149 | 3 | 0 | 3 |
| DHX57 | SLC39A1 | 0.726598 | 3 | 0 | 3 |
| DHX57 | RAB34 | 0.718822 | 3 | 0 | 3 |
| DHX57 | RCAN1 | 0.717207 | 3 | 0 | 3 |
| DHX57 | SLC30A7 | 0.714601 | 3 | 0 | 3 |
For details and further investigation, click here
