ERBB3

 

Full name: erb-b2 receptor tyrosine kinase 3 Alias Symbol: HER3
Type: protein-coding gene Cytoband: 12q13.2
Entrez ID: 2065 HGNC ID: HGNC:3431 Ensembl Gene: ENSG00000065361 OMIM ID: 190151
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 21/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ERBB3 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04020Calcium signaling pathway
hsa05205Proteoglycans in cancer

 

Expression of ERBB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ERBB3 2065 226213_at -0.8992 0.3490
GSE20347 ERBB3 2065 202454_s_at -1.4630 0.0000
GSE23400 ERBB3 2065 202454_s_at -1.2060 0.0000
GSE26886 ERBB3 2065 226213_at -1.4165 0.0006
GSE29001 ERBB3 2065 202454_s_at -1.4717 0.0007
GSE38129 ERBB3 2065 202454_s_at -1.2782 0.0002
GSE45670 ERBB3 2065 226213_at -0.6199 0.0327
GSE53622 ERBB3 2065 71863 -1.6989 0.0000
GSE53624 ERBB3 2065 71863 -1.8159 0.0000
GSE63941 ERBB3 2065 226213_at 4.3888 0.0019
GSE77861 ERBB3 2065 226213_at -1.1514 0.0019
GSE97050 ERBB3 2065 A_33_P3280471 -0.5920 0.1512
SRP007169 ERBB3 2065 RNAseq -2.3939 0.0000
SRP008496 ERBB3 2065 RNAseq -2.8068 0.0000
SRP064894 ERBB3 2065 RNAseq -1.9816 0.0000
SRP133303 ERBB3 2065 RNAseq -1.1575 0.0001
SRP159526 ERBB3 2065 RNAseq -0.9072 0.1387
SRP193095 ERBB3 2065 RNAseq -1.3248 0.0000
SRP219564 ERBB3 2065 RNAseq -1.8205 0.0125
TCGA ERBB3 2065 RNAseq -0.3362 0.0019

Upregulated datasets: 1; Downregulated datasets: 14.  

 

Survival by ERBB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ERBB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ERBB3 2065 7 2 21
GSE20123 ERBB3 2065 7 1 22
GSE43470 ERBB3 2065 4 0 39
GSE46452 ERBB3 2065 8 1 50
GSE47630 ERBB3 2065 10 2 28
GSE54993 ERBB3 2065 0 5 65
GSE54994 ERBB3 2065 4 1 48
GSE60625 ERBB3 2065 0 0 11
GSE74703 ERBB3 2065 4 0 32
GSE74704 ERBB3 2065 4 1 15
TCGA ERBB3 2065 15 10 71

Total number of gains: 63; Total number of losses: 23; Total Number of normals: 402.  

 

Somatic mutations of ERBB3:

 

Generating mutation plots.

 

Highly correlated genes for ERBB3:

 

Showing top 20/1356 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ERBB3CHP10.81555810010
ERBB3FAM214A0.80386606
ERBB3ANXA110.7916110010
ERBB3EVPL0.79052712012
ERBB3USP540.785334707
ERBB3KIAA1211L0.782462707
ERBB3RAB250.78046913012
ERBB3RHCG0.7804210010
ERBB3SCNN1A0.77787212012
ERBB3ELF30.77754413013
ERBB3EMP10.77710211011
ERBB3FBXO340.77416512011
ERBB3FUT30.77371413012
ERBB3GGT60.772039807
ERBB3PPL0.77138913012
ERBB3EPS8L20.76976911010
ERBB3ST6GALNAC10.768881808
ERBB3NT5C20.76818311010
ERBB3CCDC60.76513210010
ERBB3UBL30.76104411011

For details and further investigation, click here