ELF3

 

Full name: E74 like ETS transcription factor 3 Alias Symbol: EPR-1|ESE-1|ERT
Type: protein-coding gene Cytoband: 1q32.1
Entrez ID: 1999 HGNC ID: HGNC:3318 Ensembl Gene: ENSG00000163435 OMIM ID: 602191
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ELF3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ELF3 1999 210827_s_at -1.0662 0.2924
GSE20347 ELF3 1999 210827_s_at -1.0869 0.0021
GSE23400 ELF3 1999 210827_s_at -1.5166 0.0000
GSE26886 ELF3 1999 210827_s_at -2.1164 0.0001
GSE29001 ELF3 1999 210827_s_at -2.0436 0.0011
GSE38129 ELF3 1999 210827_s_at -0.6265 0.1538
GSE45670 ELF3 1999 210827_s_at -0.3746 0.2528
GSE53622 ELF3 1999 51582 -1.3821 0.0000
GSE53624 ELF3 1999 51582 -1.6993 0.0000
GSE63941 ELF3 1999 210827_s_at 3.1555 0.0095
GSE77861 ELF3 1999 210827_s_at -0.8102 0.0130
GSE97050 ELF3 1999 A_23_P104188 0.1918 0.8837
SRP007169 ELF3 1999 RNAseq -3.1769 0.0000
SRP008496 ELF3 1999 RNAseq -3.3687 0.0000
SRP064894 ELF3 1999 RNAseq -2.6002 0.0000
SRP133303 ELF3 1999 RNAseq -1.0149 0.0109
SRP159526 ELF3 1999 RNAseq -1.7006 0.0030
SRP193095 ELF3 1999 RNAseq -1.4971 0.0000
SRP219564 ELF3 1999 RNAseq -1.7578 0.1293
TCGA ELF3 1999 RNAseq 0.0004 0.9983

Upregulated datasets: 1; Downregulated datasets: 12.  

 

Survival by ELF3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ELF3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ELF3 1999 11 0 19
GSE20123 ELF3 1999 11 0 19
GSE43470 ELF3 1999 6 0 37
GSE46452 ELF3 1999 3 1 55
GSE47630 ELF3 1999 14 0 26
GSE54993 ELF3 1999 0 6 64
GSE54994 ELF3 1999 15 0 38
GSE60625 ELF3 1999 0 0 11
GSE74703 ELF3 1999 6 0 30
GSE74704 ELF3 1999 5 0 15
TCGA ELF3 1999 43 4 49

Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.  

 

Somatic mutations of ELF3:

 

Generating mutation plots.

 

Highly correlated genes for ELF3:

 

Showing top 20/1156 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ELF3FUT30.79965313013
ELF3MUC200.798082808
ELF3SCNN1A0.78597913013
ELF3ERBB30.77754413013
ELF3CEACAM50.77159613013
ELF3MACC10.766828808
ELF3CLDN40.76382311010
ELF3UPK3B0.762604303
ELF3CEACAM60.76120313013
ELF3CLDN70.75890413013
ELF3PAX90.75848713012
ELF3LIPH0.75713908
ELF3RBM470.75704713013
ELF3EVPL0.75347412012
ELF3FAM214A0.753031606
ELF3ULK30.751089606
ELF3TAB30.747171606
ELF3PITX10.74359912011
ELF3TMPRSS20.74255312012
ELF3TACSTD20.7420813013

For details and further investigation, click here