| Full name: periplakin | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 5493 | HGNC ID: HGNC:9273 | Ensembl Gene: ENSG00000118898 | OMIM ID: 602871 |
| Drug and gene relationship at DGIdb | |||
Expression of PPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPL | 5493 | 203407_at | -2.2517 | 0.1480 | |
| GSE20347 | PPL | 5493 | 203407_at | -2.9336 | 0.0000 | |
| GSE23400 | PPL | 5493 | 203407_at | -2.5646 | 0.0000 | |
| GSE26886 | PPL | 5493 | 203407_at | -3.8839 | 0.0000 | |
| GSE29001 | PPL | 5493 | 203407_at | -2.9971 | 0.0000 | |
| GSE38129 | PPL | 5493 | 203407_at | -2.2491 | 0.0000 | |
| GSE45670 | PPL | 5493 | 203407_at | -1.0155 | 0.0125 | |
| GSE53622 | PPL | 5493 | 7356 | -2.2787 | 0.0000 | |
| GSE53624 | PPL | 5493 | 7356 | -2.7003 | 0.0000 | |
| GSE63941 | PPL | 5493 | 203407_at | 2.9649 | 0.0100 | |
| GSE77861 | PPL | 5493 | 203407_at | -2.1441 | 0.0046 | |
| GSE97050 | PPL | 5493 | A_23_P106906 | -1.5252 | 0.1210 | |
| SRP007169 | PPL | 5493 | RNAseq | -3.9857 | 0.0000 | |
| SRP008496 | PPL | 5493 | RNAseq | -4.0355 | 0.0000 | |
| SRP064894 | PPL | 5493 | RNAseq | -4.8625 | 0.0000 | |
| SRP133303 | PPL | 5493 | RNAseq | -3.7470 | 0.0000 | |
| SRP159526 | PPL | 5493 | RNAseq | -4.3792 | 0.0000 | |
| SRP193095 | PPL | 5493 | RNAseq | -3.8114 | 0.0000 | |
| SRP219564 | PPL | 5493 | RNAseq | -4.7577 | 0.0000 | |
| TCGA | PPL | 5493 | RNAseq | 0.1899 | 0.1562 |
Upregulated datasets: 1; Downregulated datasets: 16.
Survival by PPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPL | 5493 | 6 | 4 | 20 | |
| GSE20123 | PPL | 5493 | 6 | 3 | 21 | |
| GSE43470 | PPL | 5493 | 4 | 5 | 34 | |
| GSE46452 | PPL | 5493 | 38 | 1 | 20 | |
| GSE47630 | PPL | 5493 | 13 | 6 | 21 | |
| GSE54993 | PPL | 5493 | 3 | 5 | 62 | |
| GSE54994 | PPL | 5493 | 5 | 9 | 39 | |
| GSE60625 | PPL | 5493 | 4 | 0 | 7 | |
| GSE74703 | PPL | 5493 | 4 | 4 | 28 | |
| GSE74704 | PPL | 5493 | 3 | 2 | 15 | |
| TCGA | PPL | 5493 | 19 | 13 | 64 |
Total number of gains: 105; Total number of losses: 52; Total Number of normals: 331.
Somatic mutations of PPL:
Generating mutation plots.
Highly correlated genes for PPL:
Showing top 20/1526 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPL | CSTB | 0.903335 | 12 | 0 | 12 |
| PPL | SCEL | 0.895565 | 13 | 0 | 12 |
| PPL | CLIC3 | 0.891488 | 10 | 0 | 10 |
| PPL | VSIG10L | 0.886654 | 7 | 0 | 7 |
| PPL | EMP1 | 0.886537 | 12 | 0 | 12 |
| PPL | TGM1 | 0.881599 | 12 | 0 | 12 |
| PPL | MALL | 0.881241 | 12 | 0 | 12 |
| PPL | CRNN | 0.879596 | 12 | 0 | 12 |
| PPL | EVPL | 0.877399 | 13 | 0 | 13 |
| PPL | CRISP3 | 0.877367 | 11 | 0 | 11 |
| PPL | KLK13 | 0.875303 | 12 | 0 | 12 |
| PPL | TMPRSS11B | 0.874055 | 8 | 0 | 8 |
| PPL | SPINK5 | 0.869316 | 13 | 0 | 12 |
| PPL | ZNF185 | 0.868442 | 13 | 0 | 13 |
| PPL | ENDOU | 0.867998 | 12 | 0 | 11 |
| PPL | RHCG | 0.865757 | 12 | 0 | 12 |
| PPL | KRT78 | 0.865702 | 8 | 0 | 8 |
| PPL | CRCT1 | 0.865365 | 12 | 0 | 12 |
| PPL | FAM214A | 0.864189 | 6 | 0 | 6 |
| PPL | CXCR2 | 0.862082 | 10 | 0 | 10 |
For details and further investigation, click here
