| Full name: LPS responsive beige-like anchor protein | Alias Symbol: BGL|LAB300|LBA | ||
| Type: protein-coding gene | Cytoband: 4q31.3 | ||
| Entrez ID: 987 | HGNC ID: HGNC:1742 | Ensembl Gene: ENSG00000198589 | OMIM ID: 606453 |
| Drug and gene relationship at DGIdb | |||
Expression of LRBA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRBA | 987 | 212692_s_at | -0.0963 | 0.8977 | |
| GSE20347 | LRBA | 987 | 212692_s_at | -1.0521 | 0.0000 | |
| GSE23400 | LRBA | 987 | 212692_s_at | -0.5250 | 0.0000 | |
| GSE26886 | LRBA | 987 | 212692_s_at | -1.3987 | 0.0005 | |
| GSE29001 | LRBA | 987 | 212692_s_at | -0.8835 | 0.0000 | |
| GSE38129 | LRBA | 987 | 212692_s_at | -0.7014 | 0.0001 | |
| GSE45670 | LRBA | 987 | 212692_s_at | -0.5403 | 0.0005 | |
| GSE53622 | LRBA | 987 | 116249 | -0.7852 | 0.0000 | |
| GSE53624 | LRBA | 987 | 116249 | -1.0193 | 0.0000 | |
| GSE63941 | LRBA | 987 | 212692_s_at | -0.1444 | 0.7123 | |
| GSE77861 | LRBA | 987 | 212692_s_at | -0.6105 | 0.0138 | |
| GSE97050 | LRBA | 987 | A_24_P360078 | 0.0601 | 0.8730 | |
| SRP007169 | LRBA | 987 | RNAseq | -0.8341 | 0.0442 | |
| SRP008496 | LRBA | 987 | RNAseq | -0.7326 | 0.0066 | |
| SRP064894 | LRBA | 987 | RNAseq | -1.1420 | 0.0000 | |
| SRP133303 | LRBA | 987 | RNAseq | -0.4002 | 0.0493 | |
| SRP159526 | LRBA | 987 | RNAseq | -0.7808 | 0.0002 | |
| SRP193095 | LRBA | 987 | RNAseq | -0.7512 | 0.0000 | |
| SRP219564 | LRBA | 987 | RNAseq | -1.3292 | 0.0050 | |
| TCGA | LRBA | 987 | RNAseq | -0.1790 | 0.0018 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by LRBA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRBA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRBA | 987 | 1 | 13 | 16 | |
| GSE20123 | LRBA | 987 | 1 | 13 | 16 | |
| GSE43470 | LRBA | 987 | 0 | 14 | 29 | |
| GSE46452 | LRBA | 987 | 1 | 36 | 22 | |
| GSE47630 | LRBA | 987 | 0 | 23 | 17 | |
| GSE54993 | LRBA | 987 | 10 | 0 | 60 | |
| GSE54994 | LRBA | 987 | 1 | 12 | 40 | |
| GSE60625 | LRBA | 987 | 0 | 1 | 10 | |
| GSE74703 | LRBA | 987 | 0 | 12 | 24 | |
| GSE74704 | LRBA | 987 | 0 | 7 | 13 | |
| TCGA | LRBA | 987 | 12 | 35 | 49 |
Total number of gains: 26; Total number of losses: 166; Total Number of normals: 296.
Somatic mutations of LRBA:
Generating mutation plots.
Highly correlated genes for LRBA:
Showing top 20/1707 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRBA | SMDT1 | 0.782403 | 3 | 0 | 3 |
| LRBA | GRPEL2 | 0.768677 | 7 | 0 | 7 |
| LRBA | RBM20 | 0.765114 | 4 | 0 | 4 |
| LRBA | NAGK | 0.765026 | 11 | 0 | 11 |
| LRBA | BLNK | 0.761093 | 11 | 0 | 11 |
| LRBA | GFPT1 | 0.760417 | 4 | 0 | 4 |
| LRBA | SNORA68 | 0.755037 | 3 | 0 | 3 |
| LRBA | UNC13D | 0.749173 | 3 | 0 | 3 |
| LRBA | SLC16A6 | 0.746171 | 11 | 0 | 11 |
| LRBA | HSD17B4 | 0.746069 | 11 | 0 | 11 |
| LRBA | WDR26 | 0.746026 | 11 | 0 | 11 |
| LRBA | HPGD | 0.744814 | 10 | 0 | 10 |
| LRBA | RAB25 | 0.744401 | 11 | 0 | 11 |
| LRBA | RAB11A | 0.743316 | 11 | 0 | 11 |
| LRBA | RMND5B | 0.740892 | 11 | 0 | 10 |
| LRBA | KIAA1211L | 0.739705 | 5 | 0 | 5 |
| LRBA | SORT1 | 0.739258 | 10 | 0 | 10 |
| LRBA | IMPACT | 0.737948 | 3 | 0 | 3 |
| LRBA | IST1 | 0.737528 | 3 | 0 | 3 |
| LRBA | ARHGAP27 | 0.735827 | 7 | 0 | 7 |
For details and further investigation, click here
