| Full name: charged multivesicular body protein 2B | Alias Symbol: DKFZP564O123|CHMP2.5|VPS2B | ||
| Type: protein-coding gene | Cytoband: 3p11.2 | ||
| Entrez ID: 25978 | HGNC ID: HGNC:24537 | Ensembl Gene: ENSG00000083937 | OMIM ID: 609512 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of CHMP2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHMP2B | 25978 | 202538_s_at | -0.7786 | 0.0399 | |
| GSE20347 | CHMP2B | 25978 | 202537_s_at | -1.3587 | 0.0000 | |
| GSE23400 | CHMP2B | 25978 | 202538_s_at | -0.5774 | 0.0000 | |
| GSE26886 | CHMP2B | 25978 | 202536_at | -2.1961 | 0.0000 | |
| GSE29001 | CHMP2B | 25978 | 202538_s_at | -1.1482 | 0.0014 | |
| GSE38129 | CHMP2B | 25978 | 202537_s_at | -1.1693 | 0.0000 | |
| GSE45670 | CHMP2B | 25978 | 202538_s_at | -0.7218 | 0.0003 | |
| GSE53622 | CHMP2B | 25978 | 7124 | -0.8749 | 0.0000 | |
| GSE53624 | CHMP2B | 25978 | 7124 | -1.0982 | 0.0000 | |
| GSE63941 | CHMP2B | 25978 | 202537_s_at | 0.2511 | 0.7047 | |
| GSE77861 | CHMP2B | 25978 | 202538_s_at | -0.8983 | 0.0010 | |
| GSE97050 | CHMP2B | 25978 | A_24_P114617 | -0.7771 | 0.0631 | |
| SRP007169 | CHMP2B | 25978 | RNAseq | -2.2538 | 0.0000 | |
| SRP008496 | CHMP2B | 25978 | RNAseq | -1.8551 | 0.0000 | |
| SRP064894 | CHMP2B | 25978 | RNAseq | -0.8520 | 0.0000 | |
| SRP133303 | CHMP2B | 25978 | RNAseq | -0.5041 | 0.0091 | |
| SRP159526 | CHMP2B | 25978 | RNAseq | -0.6620 | 0.1633 | |
| SRP193095 | CHMP2B | 25978 | RNAseq | -1.3834 | 0.0000 | |
| SRP219564 | CHMP2B | 25978 | RNAseq | -1.2910 | 0.0001 | |
| TCGA | CHMP2B | 25978 | RNAseq | -0.2221 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by CHMP2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHMP2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHMP2B | 25978 | 3 | 16 | 11 | |
| GSE20123 | CHMP2B | 25978 | 3 | 16 | 11 | |
| GSE43470 | CHMP2B | 25978 | 2 | 20 | 21 | |
| GSE46452 | CHMP2B | 25978 | 3 | 16 | 40 | |
| GSE47630 | CHMP2B | 25978 | 4 | 18 | 18 | |
| GSE54993 | CHMP2B | 25978 | 4 | 3 | 63 | |
| GSE54994 | CHMP2B | 25978 | 3 | 27 | 23 | |
| GSE60625 | CHMP2B | 25978 | 0 | 6 | 5 | |
| GSE74703 | CHMP2B | 25978 | 2 | 18 | 16 | |
| GSE74704 | CHMP2B | 25978 | 2 | 11 | 7 | |
| TCGA | CHMP2B | 25978 | 3 | 71 | 22 |
Total number of gains: 29; Total number of losses: 222; Total Number of normals: 237.
Somatic mutations of CHMP2B:
Generating mutation plots.
Highly correlated genes for CHMP2B:
Showing top 20/1846 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHMP2B | UBQLN1 | 0.805544 | 3 | 0 | 3 |
| CHMP2B | EPB41L3 | 0.796822 | 11 | 0 | 11 |
| CHMP2B | RBM20 | 0.789072 | 4 | 0 | 4 |
| CHMP2B | IMPACT | 0.783202 | 3 | 0 | 3 |
| CHMP2B | A2ML1 | 0.781786 | 6 | 0 | 6 |
| CHMP2B | RAB11A | 0.781308 | 11 | 0 | 11 |
| CHMP2B | LRRFIP2 | 0.778378 | 11 | 0 | 11 |
| CHMP2B | BRK1 | 0.776953 | 7 | 0 | 7 |
| CHMP2B | RAB5A | 0.773663 | 12 | 0 | 12 |
| CHMP2B | CPPED1 | 0.770682 | 11 | 0 | 11 |
| CHMP2B | KRT78 | 0.770505 | 6 | 0 | 6 |
| CHMP2B | EVC2 | 0.770176 | 3 | 0 | 3 |
| CHMP2B | RANBP9 | 0.770087 | 11 | 0 | 11 |
| CHMP2B | CA13 | 0.769671 | 3 | 0 | 3 |
| CHMP2B | EMC3 | 0.769514 | 10 | 0 | 10 |
| CHMP2B | KCTD6 | 0.769135 | 7 | 0 | 7 |
| CHMP2B | C18orf25 | 0.769033 | 11 | 0 | 11 |
| CHMP2B | RNF141 | 0.767346 | 11 | 0 | 11 |
| CHMP2B | KAT2B | 0.765929 | 12 | 0 | 11 |
| CHMP2B | CNN3 | 0.765743 | 9 | 0 | 9 |
For details and further investigation, click here
