| Full name: exocyst complex component 7 | Alias Symbol: EXO70|KIAA1067|YJL085W|Exo70p|BLOM4 | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 23265 | HGNC ID: HGNC:23214 | Ensembl Gene: ENSG00000182473 | OMIM ID: 608163 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
EXOC7 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway |
Expression of EXOC7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOC7 | 23265 | 212034_s_at | 0.0833 | 0.9078 | |
| GSE20347 | EXOC7 | 23265 | 212034_s_at | -0.2393 | 0.0737 | |
| GSE23400 | EXOC7 | 23265 | 212034_s_at | -0.1032 | 0.1269 | |
| GSE26886 | EXOC7 | 23265 | 212034_s_at | -0.0447 | 0.8532 | |
| GSE29001 | EXOC7 | 23265 | 212034_s_at | -0.1547 | 0.5817 | |
| GSE38129 | EXOC7 | 23265 | 212034_s_at | -0.2792 | 0.0041 | |
| GSE45670 | EXOC7 | 23265 | 212034_s_at | -0.0553 | 0.6625 | |
| GSE53622 | EXOC7 | 23265 | 133402 | -0.3170 | 0.0000 | |
| GSE53624 | EXOC7 | 23265 | 133402 | -0.2786 | 0.0000 | |
| GSE63941 | EXOC7 | 23265 | 212034_s_at | -0.3906 | 0.1974 | |
| GSE77861 | EXOC7 | 23265 | 212034_s_at | -0.0789 | 0.6910 | |
| GSE97050 | EXOC7 | 23265 | A_23_P89163 | -0.0747 | 0.7562 | |
| SRP007169 | EXOC7 | 23265 | RNAseq | 0.3809 | 0.3031 | |
| SRP008496 | EXOC7 | 23265 | RNAseq | 0.3565 | 0.2333 | |
| SRP064894 | EXOC7 | 23265 | RNAseq | -0.1688 | 0.2681 | |
| SRP133303 | EXOC7 | 23265 | RNAseq | -0.1474 | 0.4455 | |
| SRP159526 | EXOC7 | 23265 | RNAseq | -0.1625 | 0.5200 | |
| SRP193095 | EXOC7 | 23265 | RNAseq | -0.1840 | 0.0582 | |
| SRP219564 | EXOC7 | 23265 | RNAseq | -0.5242 | 0.0237 | |
| TCGA | EXOC7 | 23265 | RNAseq | -0.0412 | 0.3140 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EXOC7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOC7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOC7 | 23265 | 7 | 2 | 21 | |
| GSE20123 | EXOC7 | 23265 | 7 | 2 | 21 | |
| GSE43470 | EXOC7 | 23265 | 5 | 3 | 35 | |
| GSE46452 | EXOC7 | 23265 | 34 | 0 | 25 | |
| GSE47630 | EXOC7 | 23265 | 8 | 1 | 31 | |
| GSE54993 | EXOC7 | 23265 | 2 | 5 | 63 | |
| GSE54994 | EXOC7 | 23265 | 10 | 4 | 39 | |
| GSE60625 | EXOC7 | 23265 | 6 | 0 | 5 | |
| GSE74703 | EXOC7 | 23265 | 5 | 1 | 30 | |
| GSE74704 | EXOC7 | 23265 | 5 | 1 | 14 | |
| TCGA | EXOC7 | 23265 | 31 | 10 | 55 |
Total number of gains: 120; Total number of losses: 29; Total Number of normals: 339.
Somatic mutations of EXOC7:
Generating mutation plots.
Highly correlated genes for EXOC7:
Showing top 20/44 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOC7 | RAB40B | 0.669016 | 4 | 0 | 3 |
| EXOC7 | ABCA2 | 0.656379 | 3 | 0 | 3 |
| EXOC7 | DNAL4 | 0.607454 | 3 | 0 | 3 |
| EXOC7 | CASKIN2 | 0.589192 | 4 | 0 | 3 |
| EXOC7 | CACNB3 | 0.587983 | 6 | 0 | 5 |
| EXOC7 | WBP1L | 0.580299 | 6 | 0 | 5 |
| EXOC7 | HIF1AN | 0.567043 | 3 | 0 | 3 |
| EXOC7 | VARS2 | 0.563505 | 5 | 0 | 5 |
| EXOC7 | TCTA | 0.562701 | 4 | 0 | 3 |
| EXOC7 | TRIM2 | 0.544463 | 5 | 0 | 3 |
| EXOC7 | BAZ2A | 0.543196 | 5 | 0 | 3 |
| EXOC7 | RAF1 | 0.542114 | 5 | 0 | 3 |
| EXOC7 | ZNF526 | 0.539577 | 4 | 0 | 3 |
| EXOC7 | LRCH4 | 0.537525 | 9 | 0 | 6 |
| EXOC7 | ZNF524 | 0.531064 | 4 | 0 | 3 |
| EXOC7 | CEMP1 | 0.53032 | 3 | 0 | 3 |
| EXOC7 | PAF1 | 0.528667 | 8 | 0 | 4 |
| EXOC7 | FDXR | 0.528455 | 7 | 0 | 3 |
| EXOC7 | TAOK2 | 0.527856 | 6 | 0 | 4 |
| EXOC7 | ZZEF1 | 0.52469 | 7 | 0 | 4 |
For details and further investigation, click here
