| Full name: ferredoxin reductase | Alias Symbol: ADR | ||
| Type: protein-coding gene | Cytoband: 17q25.1 | ||
| Entrez ID: 2232 | HGNC ID: HGNC:3642 | Ensembl Gene: ENSG00000161513 | OMIM ID: 103270 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FDXR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FDXR | 2232 | 207813_s_at | 0.1187 | 0.9200 | |
| GSE20347 | FDXR | 2232 | 207813_s_at | -0.4643 | 0.0024 | |
| GSE23400 | FDXR | 2232 | 207813_s_at | -0.2329 | 0.0425 | |
| GSE26886 | FDXR | 2232 | 207813_s_at | -0.0431 | 0.8628 | |
| GSE29001 | FDXR | 2232 | 207813_s_at | -0.2877 | 0.4453 | |
| GSE38129 | FDXR | 2232 | 207813_s_at | -0.0110 | 0.9638 | |
| GSE45670 | FDXR | 2232 | 207813_s_at | 0.2935 | 0.1460 | |
| GSE53622 | FDXR | 2232 | 31881 | -0.3811 | 0.0059 | |
| GSE53624 | FDXR | 2232 | 5243 | -0.2571 | 0.0013 | |
| GSE63941 | FDXR | 2232 | 207813_s_at | 0.4512 | 0.3804 | |
| GSE77861 | FDXR | 2232 | 207813_s_at | 0.1005 | 0.6203 | |
| GSE97050 | FDXR | 2232 | A_23_P38154 | 0.2266 | 0.5169 | |
| SRP007169 | FDXR | 2232 | RNAseq | -0.6360 | 0.1571 | |
| SRP008496 | FDXR | 2232 | RNAseq | -0.7247 | 0.0078 | |
| SRP064894 | FDXR | 2232 | RNAseq | 0.4327 | 0.1487 | |
| SRP133303 | FDXR | 2232 | RNAseq | -0.1613 | 0.5874 | |
| SRP159526 | FDXR | 2232 | RNAseq | -0.1762 | 0.5765 | |
| SRP193095 | FDXR | 2232 | RNAseq | -0.4530 | 0.0227 | |
| SRP219564 | FDXR | 2232 | RNAseq | 0.0814 | 0.8627 | |
| TCGA | FDXR | 2232 | RNAseq | 0.3107 | 0.0021 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FDXR expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FDXR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FDXR | 2232 | 6 | 2 | 22 | |
| GSE20123 | FDXR | 2232 | 6 | 2 | 22 | |
| GSE43470 | FDXR | 2232 | 5 | 3 | 35 | |
| GSE46452 | FDXR | 2232 | 33 | 0 | 26 | |
| GSE47630 | FDXR | 2232 | 8 | 1 | 31 | |
| GSE54993 | FDXR | 2232 | 2 | 5 | 63 | |
| GSE54994 | FDXR | 2232 | 10 | 4 | 39 | |
| GSE60625 | FDXR | 2232 | 6 | 0 | 5 | |
| GSE74703 | FDXR | 2232 | 5 | 1 | 30 | |
| GSE74704 | FDXR | 2232 | 4 | 1 | 15 | |
| TCGA | FDXR | 2232 | 32 | 10 | 54 |
Total number of gains: 117; Total number of losses: 29; Total Number of normals: 342.
Somatic mutations of FDXR:
Generating mutation plots.
Highly correlated genes for FDXR:
Showing top 20/400 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FDXR | FAM160A1 | 0.726838 | 3 | 0 | 3 |
| FDXR | LIPH | 0.716415 | 3 | 0 | 3 |
| FDXR | BTBD11 | 0.705858 | 3 | 0 | 3 |
| FDXR | SLC22A23 | 0.705573 | 3 | 0 | 3 |
| FDXR | RHOV | 0.701343 | 3 | 0 | 3 |
| FDXR | LAD1 | 0.683719 | 7 | 0 | 7 |
| FDXR | GRHL1 | 0.682878 | 3 | 0 | 3 |
| FDXR | RNF170 | 0.68005 | 4 | 0 | 4 |
| FDXR | ARMC7 | 0.678374 | 3 | 0 | 3 |
| FDXR | TMPRSS4 | 0.66064 | 6 | 0 | 5 |
| FDXR | AHRR | 0.659395 | 3 | 0 | 3 |
| FDXR | SLC27A4 | 0.659141 | 4 | 0 | 3 |
| FDXR | S100A16 | 0.653667 | 4 | 0 | 3 |
| FDXR | EIF6 | 0.649723 | 7 | 0 | 6 |
| FDXR | BSPRY | 0.649618 | 5 | 0 | 4 |
| FDXR | KIAA1522 | 0.646139 | 3 | 0 | 3 |
| FDXR | AACS | 0.640757 | 6 | 0 | 4 |
| FDXR | DUOXA1 | 0.640566 | 5 | 0 | 4 |
| FDXR | TRIM29 | 0.637659 | 7 | 0 | 6 |
| FDXR | CDCP1 | 0.63584 | 4 | 0 | 4 |
For details and further investigation, click here
