| Full name: PAF1 homolog, Paf1/RNA polymerase II complex component | Alias Symbol: PD2|F23149_1|FLJ11123 | ||
| Type: protein-coding gene | Cytoband: 19q13.1 | ||
| Entrez ID: 54623 | HGNC ID: HGNC:25459 | Ensembl Gene: ENSG00000006712 | OMIM ID: 610506 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PAF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PAF1 | 54623 | 202093_s_at | -0.3327 | 0.3385 | |
| GSE20347 | PAF1 | 54623 | 202093_s_at | -0.3442 | 0.0279 | |
| GSE23400 | PAF1 | 54623 | 202093_s_at | -0.2355 | 0.0002 | |
| GSE26886 | PAF1 | 54623 | 202093_s_at | -0.3706 | 0.1079 | |
| GSE29001 | PAF1 | 54623 | 202093_s_at | -0.1282 | 0.7151 | |
| GSE38129 | PAF1 | 54623 | 202093_s_at | -0.2841 | 0.0211 | |
| GSE45670 | PAF1 | 54623 | 202093_s_at | -0.0559 | 0.7421 | |
| GSE53622 | PAF1 | 54623 | 101346 | -0.4728 | 0.0000 | |
| GSE53624 | PAF1 | 54623 | 101346 | -0.3265 | 0.0000 | |
| GSE63941 | PAF1 | 54623 | 202093_s_at | -0.7319 | 0.0862 | |
| GSE77861 | PAF1 | 54623 | 202093_s_at | 0.0166 | 0.9626 | |
| GSE97050 | PAF1 | 54623 | A_24_P216087 | -0.4435 | 0.1186 | |
| SRP007169 | PAF1 | 54623 | RNAseq | -0.0863 | 0.8951 | |
| SRP008496 | PAF1 | 54623 | RNAseq | -0.4201 | 0.3855 | |
| SRP064894 | PAF1 | 54623 | RNAseq | 0.0379 | 0.8676 | |
| SRP133303 | PAF1 | 54623 | RNAseq | -0.1928 | 0.1763 | |
| SRP159526 | PAF1 | 54623 | RNAseq | -0.1286 | 0.6242 | |
| SRP193095 | PAF1 | 54623 | RNAseq | -0.4074 | 0.0141 | |
| SRP219564 | PAF1 | 54623 | RNAseq | -0.3200 | 0.2809 | |
| TCGA | PAF1 | 54623 | RNAseq | -0.0398 | 0.4068 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PAF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PAF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PAF1 | 54623 | 7 | 4 | 19 | |
| GSE20123 | PAF1 | 54623 | 7 | 3 | 20 | |
| GSE43470 | PAF1 | 54623 | 3 | 11 | 29 | |
| GSE46452 | PAF1 | 54623 | 48 | 1 | 10 | |
| GSE47630 | PAF1 | 54623 | 9 | 5 | 26 | |
| GSE54993 | PAF1 | 54623 | 17 | 3 | 50 | |
| GSE54994 | PAF1 | 54623 | 7 | 9 | 37 | |
| GSE60625 | PAF1 | 54623 | 9 | 0 | 2 | |
| GSE74703 | PAF1 | 54623 | 3 | 7 | 26 | |
| GSE74704 | PAF1 | 54623 | 7 | 1 | 12 | |
| TCGA | PAF1 | 54623 | 14 | 16 | 66 |
Total number of gains: 131; Total number of losses: 60; Total Number of normals: 297.
Somatic mutations of PAF1:
Generating mutation plots.
Highly correlated genes for PAF1:
Showing top 20/101 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PAF1 | DUSP15 | 0.69538 | 3 | 0 | 3 |
| PAF1 | NUDT16L1 | 0.669034 | 3 | 0 | 3 |
| PAF1 | SUMF1 | 0.663813 | 3 | 0 | 3 |
| PAF1 | UBXN6 | 0.647655 | 3 | 0 | 3 |
| PAF1 | EIF3K | 0.640656 | 8 | 0 | 7 |
| PAF1 | CSAD | 0.607088 | 5 | 0 | 3 |
| PAF1 | LIN37 | 0.60442 | 5 | 0 | 4 |
| PAF1 | NAA16 | 0.59844 | 5 | 0 | 3 |
| PAF1 | CPEB2 | 0.598132 | 4 | 0 | 3 |
| PAF1 | CCDC22 | 0.597223 | 3 | 0 | 3 |
| PAF1 | GABARAP | 0.592313 | 4 | 0 | 3 |
| PAF1 | IRGQ | 0.591365 | 6 | 0 | 4 |
| PAF1 | FAT4 | 0.582146 | 4 | 0 | 3 |
| PAF1 | AFF4 | 0.580402 | 8 | 0 | 5 |
| PAF1 | PLCD4 | 0.577461 | 4 | 0 | 3 |
| PAF1 | MOB2 | 0.576763 | 5 | 0 | 3 |
| PAF1 | FBXO24 | 0.576722 | 3 | 0 | 3 |
| PAF1 | LMOD1 | 0.576415 | 5 | 0 | 4 |
| PAF1 | DCLK1 | 0.572681 | 4 | 0 | 3 |
| PAF1 | MAGEA8 | 0.572074 | 3 | 0 | 3 |
For details and further investigation, click here
