| Full name: valyl-tRNA synthetase 2, mitochondrial | Alias Symbol: DKFZP434L1435|KIAA1885|G7a | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 57176 | HGNC ID: HGNC:21642 | Ensembl Gene: ENSG00000137411 | OMIM ID: 612802 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VARS2 | 57176 | 226200_at | 0.1590 | 0.8543 | |
| GSE26886 | VARS2 | 57176 | 226200_at | 0.0405 | 0.8764 | |
| GSE45670 | VARS2 | 57176 | 226200_at | -0.4609 | 0.0065 | |
| GSE53622 | VARS2 | 57176 | 11359 | -0.8101 | 0.0000 | |
| GSE53624 | VARS2 | 57176 | 11359 | -0.7578 | 0.0000 | |
| GSE63941 | VARS2 | 57176 | 226200_at | 1.3289 | 0.0217 | |
| GSE77861 | VARS2 | 57176 | 226200_at | -0.5523 | 0.0035 | |
| GSE97050 | VARS2 | 57176 | A_23_P111112 | -0.4176 | 0.3676 | |
| SRP007169 | VARS2 | 57176 | RNAseq | -1.8739 | 0.0000 | |
| SRP008496 | VARS2 | 57176 | RNAseq | -1.7373 | 0.0000 | |
| SRP064894 | VARS2 | 57176 | RNAseq | -0.5422 | 0.0019 | |
| SRP133303 | VARS2 | 57176 | RNAseq | -0.9385 | 0.0000 | |
| SRP159526 | VARS2 | 57176 | RNAseq | 0.0018 | 0.9953 | |
| SRP193095 | VARS2 | 57176 | RNAseq | -0.6480 | 0.0000 | |
| SRP219564 | VARS2 | 57176 | RNAseq | -0.3743 | 0.4906 | |
| TCGA | VARS2 | 57176 | RNAseq | -0.0239 | 0.6957 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by VARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VARS2 | 57176 | 5 | 1 | 24 | |
| GSE20123 | VARS2 | 57176 | 5 | 1 | 24 | |
| GSE43470 | VARS2 | 57176 | 6 | 1 | 36 | |
| GSE46452 | VARS2 | 57176 | 1 | 10 | 48 | |
| GSE47630 | VARS2 | 57176 | 7 | 3 | 30 | |
| GSE54993 | VARS2 | 57176 | 2 | 1 | 67 | |
| GSE54994 | VARS2 | 57176 | 11 | 4 | 38 | |
| GSE60625 | VARS2 | 57176 | 0 | 1 | 10 | |
| GSE74703 | VARS2 | 57176 | 6 | 0 | 30 | |
| GSE74704 | VARS2 | 57176 | 2 | 0 | 18 | |
| TCGA | VARS2 | 57176 | 18 | 16 | 62 |
Total number of gains: 63; Total number of losses: 38; Total Number of normals: 387.
Somatic mutations of VARS2:
Generating mutation plots.
Highly correlated genes for VARS2:
Showing top 20/632 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VARS2 | ECM1 | 0.772858 | 5 | 0 | 5 |
| VARS2 | SCEL | 0.763362 | 5 | 0 | 5 |
| VARS2 | ZNF185 | 0.75778 | 5 | 0 | 5 |
| VARS2 | CSTA | 0.754891 | 3 | 0 | 3 |
| VARS2 | ZNRF1 | 0.753092 | 3 | 0 | 3 |
| VARS2 | CES2 | 0.751427 | 3 | 0 | 3 |
| VARS2 | RHCG | 0.748461 | 5 | 0 | 5 |
| VARS2 | SLURP1 | 0.748001 | 5 | 0 | 5 |
| VARS2 | HCG22 | 0.744978 | 4 | 0 | 4 |
| VARS2 | CYSRT1 | 0.744211 | 4 | 0 | 4 |
| VARS2 | PRSS27 | 0.742132 | 5 | 0 | 5 |
| VARS2 | MXD1 | 0.741497 | 5 | 0 | 5 |
| VARS2 | IL1RN | 0.738267 | 5 | 0 | 5 |
| VARS2 | SH3BGRL2 | 0.737139 | 4 | 0 | 4 |
| VARS2 | TMPRSS11B | 0.73683 | 5 | 0 | 5 |
| VARS2 | NCCRP1 | 0.732079 | 3 | 0 | 3 |
| VARS2 | CNFN | 0.730191 | 5 | 0 | 5 |
| VARS2 | MAPK13 | 0.729263 | 7 | 0 | 6 |
| VARS2 | ACPP | 0.728309 | 6 | 0 | 6 |
| VARS2 | GCHFR | 0.719029 | 3 | 0 | 3 |
For details and further investigation, click here
