| Full name: exostosin glycosyltransferase 1 | Alias Symbol: ttv | ||
| Type: protein-coding gene | Cytoband: 8q24.11 | ||
| Entrez ID: 2131 | HGNC ID: HGNC:3512 | Ensembl Gene: ENSG00000182197 | OMIM ID: 608177 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXT1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXT1 | 2131 | 201995_at | 1.3565 | 0.0664 | |
| GSE20347 | EXT1 | 2131 | 201995_at | 0.5962 | 0.0022 | |
| GSE23400 | EXT1 | 2131 | 201995_at | 1.0379 | 0.0000 | |
| GSE26886 | EXT1 | 2131 | 201995_at | 1.8369 | 0.0000 | |
| GSE29001 | EXT1 | 2131 | 201995_at | 0.9446 | 0.0052 | |
| GSE38129 | EXT1 | 2131 | 201995_at | 0.7299 | 0.0000 | |
| GSE45670 | EXT1 | 2131 | 201995_at | 1.1873 | 0.0001 | |
| GSE53622 | EXT1 | 2131 | 121241 | 1.3234 | 0.0000 | |
| GSE53624 | EXT1 | 2131 | 121241 | 1.4826 | 0.0000 | |
| GSE63941 | EXT1 | 2131 | 201995_at | -2.5761 | 0.0004 | |
| GSE77861 | EXT1 | 2131 | 201995_at | 0.8210 | 0.0148 | |
| GSE97050 | EXT1 | 2131 | A_23_P43273 | 1.2411 | 0.0504 | |
| SRP007169 | EXT1 | 2131 | RNAseq | 1.3476 | 0.0029 | |
| SRP008496 | EXT1 | 2131 | RNAseq | 1.4927 | 0.0000 | |
| SRP064894 | EXT1 | 2131 | RNAseq | 1.4059 | 0.0000 | |
| SRP133303 | EXT1 | 2131 | RNAseq | 0.9476 | 0.0000 | |
| SRP159526 | EXT1 | 2131 | RNAseq | 1.0904 | 0.0000 | |
| SRP193095 | EXT1 | 2131 | RNAseq | 1.2187 | 0.0000 | |
| SRP219564 | EXT1 | 2131 | RNAseq | 0.8479 | 0.0437 | |
| TCGA | EXT1 | 2131 | RNAseq | 0.3230 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 1.
Survival by EXT1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXT1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXT1 | 2131 | 19 | 1 | 10 | |
| GSE20123 | EXT1 | 2131 | 20 | 1 | 9 | |
| GSE43470 | EXT1 | 2131 | 22 | 0 | 21 | |
| GSE46452 | EXT1 | 2131 | 26 | 0 | 33 | |
| GSE47630 | EXT1 | 2131 | 24 | 0 | 16 | |
| GSE54993 | EXT1 | 2131 | 0 | 20 | 50 | |
| GSE54994 | EXT1 | 2131 | 37 | 1 | 15 | |
| GSE60625 | EXT1 | 2131 | 0 | 4 | 7 | |
| GSE74703 | EXT1 | 2131 | 19 | 0 | 17 | |
| GSE74704 | EXT1 | 2131 | 13 | 1 | 6 | |
| TCGA | EXT1 | 2131 | 66 | 3 | 27 |
Total number of gains: 246; Total number of losses: 31; Total Number of normals: 211.
Somatic mutations of EXT1:
Generating mutation plots.
Highly correlated genes for EXT1:
Showing top 20/1264 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXT1 | CTHRC1 | 0.789388 | 8 | 0 | 8 |
| EXT1 | ACVR1C | 0.777903 | 4 | 0 | 4 |
| EXT1 | PDE7A | 0.747883 | 7 | 0 | 6 |
| EXT1 | TTYH3 | 0.746146 | 7 | 0 | 7 |
| EXT1 | SLC39A3 | 0.743036 | 3 | 0 | 3 |
| EXT1 | ENY2 | 0.74294 | 10 | 0 | 10 |
| EXT1 | FMNL2 | 0.742795 | 8 | 0 | 7 |
| EXT1 | MCAM | 0.739051 | 3 | 0 | 3 |
| EXT1 | NOMO1 | 0.738328 | 3 | 0 | 3 |
| EXT1 | XPR1 | 0.738166 | 7 | 0 | 7 |
| EXT1 | GALNT18 | 0.737909 | 5 | 0 | 5 |
| EXT1 | AGRN | 0.737607 | 10 | 0 | 10 |
| EXT1 | DOCK11 | 0.734464 | 3 | 0 | 3 |
| EXT1 | ALKBH6 | 0.726891 | 4 | 0 | 4 |
| EXT1 | FRMD6-AS1 | 0.718349 | 3 | 0 | 3 |
| EXT1 | SLC41A1 | 0.712721 | 6 | 0 | 6 |
| EXT1 | TMEM132A | 0.708521 | 9 | 0 | 8 |
| EXT1 | FBRSL1 | 0.706268 | 4 | 0 | 3 |
| EXT1 | FAM91A1 | 0.704343 | 6 | 0 | 6 |
| EXT1 | KRTCAP2 | 0.703913 | 4 | 0 | 4 |
For details and further investigation, click here
