| Full name: EYA transcriptional coactivator and phosphatase 3 | Alias Symbol: DKFZp686C132 | ||
| Type: protein-coding gene | Cytoband: 1p35.3 | ||
| Entrez ID: 2140 | HGNC ID: HGNC:3521 | Ensembl Gene: ENSG00000158161 | OMIM ID: 601655 |
| Drug and gene relationship at DGIdb | |||
Expression of EYA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EYA3 | 2140 | 226170_at | 0.2960 | 0.5788 | |
| GSE20347 | EYA3 | 2140 | 206379_at | -0.2380 | 0.0020 | |
| GSE23400 | EYA3 | 2140 | 206379_at | -0.2217 | 0.0000 | |
| GSE26886 | EYA3 | 2140 | 226170_at | -0.6928 | 0.0279 | |
| GSE29001 | EYA3 | 2140 | 206379_at | -0.5326 | 0.0007 | |
| GSE38129 | EYA3 | 2140 | 206379_at | -0.2147 | 0.0416 | |
| GSE45670 | EYA3 | 2140 | 226170_at | -0.0636 | 0.6751 | |
| GSE53622 | EYA3 | 2140 | 52672 | -0.2412 | 0.0100 | |
| GSE53624 | EYA3 | 2140 | 52672 | -0.4456 | 0.0000 | |
| GSE63941 | EYA3 | 2140 | 226170_at | -0.3922 | 0.2692 | |
| GSE77861 | EYA3 | 2140 | 226170_at | -0.5047 | 0.0305 | |
| GSE97050 | EYA3 | 2140 | A_23_P74737 | 0.0420 | 0.9310 | |
| SRP007169 | EYA3 | 2140 | RNAseq | -1.0987 | 0.0236 | |
| SRP008496 | EYA3 | 2140 | RNAseq | -1.1547 | 0.0002 | |
| SRP064894 | EYA3 | 2140 | RNAseq | -0.8275 | 0.0001 | |
| SRP133303 | EYA3 | 2140 | RNAseq | -0.2694 | 0.0576 | |
| SRP159526 | EYA3 | 2140 | RNAseq | -0.1767 | 0.5108 | |
| SRP193095 | EYA3 | 2140 | RNAseq | -0.6154 | 0.0000 | |
| SRP219564 | EYA3 | 2140 | RNAseq | -0.7323 | 0.1607 | |
| TCGA | EYA3 | 2140 | RNAseq | 0.1129 | 0.1421 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by EYA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EYA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EYA3 | 2140 | 0 | 6 | 24 | |
| GSE20123 | EYA3 | 2140 | 0 | 5 | 25 | |
| GSE43470 | EYA3 | 2140 | 3 | 6 | 34 | |
| GSE46452 | EYA3 | 2140 | 5 | 1 | 53 | |
| GSE47630 | EYA3 | 2140 | 8 | 3 | 29 | |
| GSE54993 | EYA3 | 2140 | 2 | 1 | 67 | |
| GSE54994 | EYA3 | 2140 | 10 | 4 | 39 | |
| GSE60625 | EYA3 | 2140 | 0 | 0 | 11 | |
| GSE74703 | EYA3 | 2140 | 2 | 4 | 30 | |
| GSE74704 | EYA3 | 2140 | 0 | 0 | 20 | |
| TCGA | EYA3 | 2140 | 11 | 23 | 62 |
Total number of gains: 41; Total number of losses: 53; Total Number of normals: 394.
Somatic mutations of EYA3:
Generating mutation plots.
Highly correlated genes for EYA3:
Showing top 20/678 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EYA3 | KIAA1522 | 0.753017 | 3 | 0 | 3 |
| EYA3 | BCL11A | 0.71458 | 3 | 0 | 3 |
| EYA3 | FAM83H | 0.693927 | 3 | 0 | 3 |
| EYA3 | SLC22A23 | 0.671304 | 3 | 0 | 3 |
| EYA3 | ZKSCAN1 | 0.670552 | 4 | 0 | 4 |
| EYA3 | ELOVL1 | 0.667214 | 3 | 0 | 3 |
| EYA3 | XCR1 | 0.665376 | 4 | 0 | 4 |
| EYA3 | CPTP | 0.660572 | 8 | 0 | 7 |
| EYA3 | PLD2 | 0.65338 | 7 | 0 | 6 |
| EYA3 | MOV10 | 0.650194 | 3 | 0 | 3 |
| EYA3 | GALE | 0.650176 | 11 | 0 | 10 |
| EYA3 | FAM107B | 0.647436 | 5 | 0 | 5 |
| EYA3 | FAM95B1 | 0.644512 | 3 | 0 | 3 |
| EYA3 | TMEM222 | 0.641728 | 3 | 0 | 3 |
| EYA3 | KAZN | 0.638962 | 11 | 0 | 9 |
| EYA3 | SAMD9L | 0.638181 | 3 | 0 | 3 |
| EYA3 | PFKFB2 | 0.635674 | 7 | 0 | 7 |
| EYA3 | ZNF121 | 0.635167 | 3 | 0 | 3 |
| EYA3 | TAB3 | 0.633652 | 6 | 0 | 6 |
| EYA3 | NPAP1 | 0.63098 | 3 | 0 | 3 |
For details and further investigation, click here
