| Full name: BAF chromatin remodeling complex subunit BCL11A | Alias Symbol: BCL11A-XL|BCL11A-L|BCL11A-S|CTIP1|HBFQTL5|ZNF856 | ||
| Type: protein-coding gene | Cytoband: 2p16.1 | ||
| Entrez ID: 53335 | HGNC ID: HGNC:13221 | Ensembl Gene: ENSG00000119866 | OMIM ID: 606557 |
| Drug and gene relationship at DGIdb | |||
Expression of BCL11A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCL11A | 53335 | 222891_s_at | 0.5090 | 0.5736 | |
| GSE20347 | BCL11A | 53335 | 219497_s_at | -0.6015 | 0.0990 | |
| GSE23400 | BCL11A | 53335 | 219498_s_at | 0.0194 | 0.8518 | |
| GSE26886 | BCL11A | 53335 | 210347_s_at | 0.9904 | 0.0071 | |
| GSE29001 | BCL11A | 53335 | 219497_s_at | -0.3314 | 0.2813 | |
| GSE38129 | BCL11A | 53335 | 219497_s_at | 0.0281 | 0.9546 | |
| GSE45670 | BCL11A | 53335 | 222891_s_at | -0.0987 | 0.8222 | |
| GSE53622 | BCL11A | 53335 | 79582 | 0.1869 | 0.3050 | |
| GSE53624 | BCL11A | 53335 | 79582 | -0.1140 | 0.3209 | |
| GSE63941 | BCL11A | 53335 | 210347_s_at | 3.6402 | 0.0026 | |
| GSE77861 | BCL11A | 53335 | 210347_s_at | -0.2561 | 0.4884 | |
| GSE97050 | BCL11A | 53335 | A_33_P3249589 | 0.6535 | 0.3497 | |
| SRP007169 | BCL11A | 53335 | RNAseq | -0.3795 | 0.5511 | |
| SRP008496 | BCL11A | 53335 | RNAseq | -0.1367 | 0.7084 | |
| SRP064894 | BCL11A | 53335 | RNAseq | -0.3999 | 0.1117 | |
| SRP133303 | BCL11A | 53335 | RNAseq | -0.0765 | 0.7935 | |
| SRP159526 | BCL11A | 53335 | RNAseq | 0.5919 | 0.1938 | |
| SRP193095 | BCL11A | 53335 | RNAseq | -0.2952 | 0.2632 | |
| SRP219564 | BCL11A | 53335 | RNAseq | -0.2050 | 0.7431 | |
| TCGA | BCL11A | 53335 | RNAseq | 0.6055 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by BCL11A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCL11A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCL11A | 53335 | 11 | 0 | 19 | |
| GSE20123 | BCL11A | 53335 | 10 | 0 | 20 | |
| GSE43470 | BCL11A | 53335 | 7 | 0 | 36 | |
| GSE46452 | BCL11A | 53335 | 2 | 3 | 54 | |
| GSE47630 | BCL11A | 53335 | 8 | 0 | 32 | |
| GSE54993 | BCL11A | 53335 | 0 | 7 | 63 | |
| GSE54994 | BCL11A | 53335 | 12 | 0 | 41 | |
| GSE60625 | BCL11A | 53335 | 0 | 3 | 8 | |
| GSE74703 | BCL11A | 53335 | 7 | 0 | 29 | |
| GSE74704 | BCL11A | 53335 | 10 | 0 | 10 | |
| TCGA | BCL11A | 53335 | 36 | 2 | 58 |
Total number of gains: 103; Total number of losses: 15; Total Number of normals: 370.
Somatic mutations of BCL11A:
Generating mutation plots.
Highly correlated genes for BCL11A:
Showing top 20/322 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCL11A | ZNF107 | 0.76874 | 3 | 0 | 3 |
| BCL11A | CHAF1A | 0.75134 | 3 | 0 | 3 |
| BCL11A | TSPAN1 | 0.723686 | 3 | 0 | 3 |
| BCL11A | ZNF680 | 0.719487 | 3 | 0 | 3 |
| BCL11A | EYA3 | 0.71458 | 3 | 0 | 3 |
| BCL11A | SPSB2 | 0.712398 | 3 | 0 | 3 |
| BCL11A | TMEM260 | 0.691589 | 3 | 0 | 3 |
| BCL11A | KRTCAP3 | 0.685122 | 3 | 0 | 3 |
| BCL11A | TMC4 | 0.684543 | 3 | 0 | 3 |
| BCL11A | SNRPE | 0.67967 | 4 | 0 | 4 |
| BCL11A | TYK2 | 0.675869 | 3 | 0 | 3 |
| BCL11A | INO80B | 0.672706 | 3 | 0 | 3 |
| BCL11A | CYHR1 | 0.671417 | 4 | 0 | 4 |
| BCL11A | GALNT3 | 0.670909 | 3 | 0 | 3 |
| BCL11A | RNF126 | 0.670548 | 3 | 0 | 3 |
| BCL11A | ZXDC | 0.669802 | 4 | 0 | 3 |
| BCL11A | SYTL1 | 0.666353 | 4 | 0 | 3 |
| BCL11A | BEND3 | 0.663623 | 3 | 0 | 3 |
| BCL11A | F11R | 0.658642 | 6 | 0 | 6 |
| BCL11A | HS6ST1 | 0.656637 | 6 | 0 | 5 |
For details and further investigation, click here
