| Full name: X-C motif chemokine receptor 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.31 | ||
| Entrez ID: 2829 | HGNC ID: HGNC:1625 | Ensembl Gene: ENSG00000173578 | OMIM ID: 600552 |
| Drug and gene relationship at DGIdb | |||
XCR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of XCR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XCR1 | 2829 | 1561226_at | 0.0191 | 0.9740 | |
| GSE20347 | XCR1 | 2829 | 221468_at | -0.2293 | 0.0002 | |
| GSE23400 | XCR1 | 2829 | 221468_at | -0.1447 | 0.0000 | |
| GSE26886 | XCR1 | 2829 | 1561226_at | -0.3005 | 0.0215 | |
| GSE29001 | XCR1 | 2829 | 221468_at | -0.2200 | 0.0805 | |
| GSE38129 | XCR1 | 2829 | 221468_at | -0.1897 | 0.0035 | |
| GSE45670 | XCR1 | 2829 | 221468_at | 0.0440 | 0.6671 | |
| GSE53622 | XCR1 | 2829 | 61649 | -0.1276 | 0.0682 | |
| GSE53624 | XCR1 | 2829 | 61649 | -0.0634 | 0.4972 | |
| GSE63941 | XCR1 | 2829 | 221468_at | 0.0003 | 0.9982 | |
| GSE77861 | XCR1 | 2829 | 1561226_at | -0.1020 | 0.4243 | |
| GSE97050 | XCR1 | 2829 | A_23_P18246 | 0.4042 | 0.3523 | |
| SRP007169 | XCR1 | 2829 | RNAseq | -2.4684 | 0.0001 | |
| SRP064894 | XCR1 | 2829 | RNAseq | -1.6000 | 0.0000 | |
| SRP133303 | XCR1 | 2829 | RNAseq | -1.1233 | 0.0013 | |
| SRP159526 | XCR1 | 2829 | RNAseq | -0.9335 | 0.3025 | |
| TCGA | XCR1 | 2829 | RNAseq | -0.8283 | 0.1161 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by XCR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XCR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XCR1 | 2829 | 0 | 17 | 13 | |
| GSE20123 | XCR1 | 2829 | 0 | 18 | 12 | |
| GSE43470 | XCR1 | 2829 | 0 | 20 | 23 | |
| GSE46452 | XCR1 | 2829 | 2 | 17 | 40 | |
| GSE47630 | XCR1 | 2829 | 2 | 23 | 15 | |
| GSE54993 | XCR1 | 2829 | 7 | 2 | 61 | |
| GSE54994 | XCR1 | 2829 | 0 | 36 | 17 | |
| GSE60625 | XCR1 | 2829 | 5 | 0 | 6 | |
| GSE74703 | XCR1 | 2829 | 0 | 15 | 21 | |
| GSE74704 | XCR1 | 2829 | 0 | 12 | 8 | |
| TCGA | XCR1 | 2829 | 1 | 75 | 20 |
Total number of gains: 17; Total number of losses: 235; Total Number of normals: 236.
Somatic mutations of XCR1:
Generating mutation plots.
Highly correlated genes for XCR1:
Showing top 20/597 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XCR1 | LRRC72 | 0.684273 | 3 | 0 | 3 |
| XCR1 | C20orf85 | 0.681306 | 3 | 0 | 3 |
| XCR1 | DEFA4 | 0.673329 | 3 | 0 | 3 |
| XCR1 | FGF6 | 0.671247 | 5 | 0 | 5 |
| XCR1 | PLA2G2E | 0.668188 | 5 | 0 | 5 |
| XCR1 | EYA3 | 0.665376 | 4 | 0 | 4 |
| XCR1 | PROP1 | 0.664543 | 5 | 0 | 5 |
| XCR1 | ZBTB7C | 0.66089 | 4 | 0 | 4 |
| XCR1 | RARG | 0.660852 | 5 | 0 | 4 |
| XCR1 | MAPK3 | 0.656985 | 5 | 0 | 4 |
| XCR1 | FGF21 | 0.656927 | 5 | 0 | 5 |
| XCR1 | CGA | 0.656762 | 4 | 0 | 4 |
| XCR1 | CLEC10A | 0.651299 | 5 | 0 | 5 |
| XCR1 | GRK6 | 0.641671 | 3 | 0 | 3 |
| XCR1 | CEACAM3 | 0.638531 | 5 | 0 | 5 |
| XCR1 | GNRHR | 0.636619 | 3 | 0 | 3 |
| XCR1 | ACR | 0.635288 | 6 | 0 | 6 |
| XCR1 | LINC00671 | 0.632456 | 3 | 0 | 3 |
| XCR1 | NPAP1 | 0.628713 | 4 | 0 | 3 |
| XCR1 | GCG | 0.626565 | 3 | 0 | 3 |
For details and further investigation, click here
